Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

E.P. Istyastono; S. Nijmeijer; H.D. Lim; A. van de Stolpe; L. Roumen; A.J. Kooistra; H.F. Vischer; I.J.P. de Esch; R. Leurs; C. de Graaf

doi:10.1021/jm201042n

Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

E.P. Istyastono, S. Nijmeijer, H.D. Lim, A. van de Stolpe, L. Roumen, A.J. Kooistra, H.F. Vischer, I.J.P. de Esch, R. Leurs, C. de Graaf

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The histamine H

Original language	English
Pages (from-to)	8136-8147
Number of pages	11
Journal	Journal of Medicinal Chemistry
Volume	54
DOIs	https://doi.org/10.1021/jm201042n
Publication status	Published - 2011

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10.1021/jm201042n

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Istyastono, E. P., Nijmeijer, S., Lim, H. D., van de Stolpe, A., Roumen, L., Kooistra, A. J., Vischer, H. F., de Esch, I. J. P., Leurs, R., & de Graaf, C. (2011). Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies. Journal of Medicinal Chemistry, 54, 8136-8147. https://doi.org/10.1021/jm201042n

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title = "Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies",

abstract = "The histamine H",

author = "E.P. Istyastono and S. Nijmeijer and H.D. Lim and \{van de Stolpe\}, A. and L. Roumen and A.J. Kooistra and H.F. Vischer and \{de Esch\}, I.J.P. and R. Leurs and \{de Graaf\}, C.",

year = "2011",

doi = "10.1021/jm201042n",

language = "English",

volume = "54",

pages = "8136--8147",

journal = "Journal of Medicinal Chemistry",

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Istyastono, EP, Nijmeijer, S, Lim, HD, van de Stolpe, A, Roumen, L, Kooistra, AJ, Vischer, HF , de Esch, IJP , Leurs, R & de Graaf, C 2011, 'Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies', Journal of Medicinal Chemistry, vol. 54, pp. 8136-8147. https://doi.org/10.1021/jm201042n

TY - JOUR

T1 - Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

AU - Istyastono, E.P.

AU - Nijmeijer, S.

AU - Lim, H.D.

AU - van de Stolpe, A.

AU - Roumen, L.

AU - Kooistra, A.J.

AU - Vischer, H.F.

AU - de Esch, I.J.P.

AU - Leurs, R.

AU - de Graaf, C.

PY - 2011

Y1 - 2011

N2 - The histamine H

AB - The histamine H

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U2 - 10.1021/jm201042n

DO - 10.1021/jm201042n

M3 - Article

SN - 0022-2623

VL - 54

SP - 8136

EP - 8147

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -

Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

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