Monoliths with chiral surface functionalization for enantioselective capillary electrochromatography

Michael Lämmerhofer, Andrea Gargano

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review


The state-of-the-art in CEC enantiomer separations with monolithic capillary columns is comprehensively reviewed. The various types of monolithic columns comprising in situ organic polymer monoliths, molecularly imprinted polymer (MIP) monoliths, silica monoliths and monoliths made from particles are discussed with a focus on materials' synthesis, chemistry and properties as well as column aspects. Monolithic MIP-type porous layer open-tubular (PLOT) columns are treated herein as well. From this survey of the literature, the authors come to the conclusion that monolithic silica capillaries appear to become the preferred column type for CEC enantiomer separations of low-molecular drugs and other chiral pharmaceuticals or chemicals. © 2010 Elsevier B.V.
Original languageEnglish
Title of host publicationJournal of Pharmaceutical and Biomedical Analysis
Number of pages33
Publication statusPublished - Dec 2010
Externally publishedYes

Publication series

NameJournal of Pharmaceutical and Biomedical Analysis


  • Capillary electrochromatography
  • Chiral stationary phase
  • Enantiomer separation
  • Molecularly imprinted polymer
  • Organic polymer and silica monolith


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