Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles

Razvan Cioc, Eelco Ruijter, Romano V.A. Orru*

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Abstract

The application of multicomponent reactions (MCRs) in the generation of compound libraries has long been recognized as a key strategy for the development of lead matter in drug discovery. Given the numerous advantages that these processes possess not only from the ability to generate large numbers of diverse compounds but also from a sustainability perspective, it is somewhat surprising that MCRs have not enjoyed such a widespread application in downstream development and the later scale-up of pharmaceutical candidates. The current chapter provides an overview of the most common MCRs with a critical focus on their perceived benefits as a sustainable technology. In addition, an overview of the combination of MCRs with other “green” technologies such as both biocatalysis and flow chemistry is also provided.

Original languageEnglish
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc
Pages237-267
Number of pages31
DOIs
Publication statusPublished - 2022

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Bibliographical note

Publisher Copyright:
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Asymmetric synthesis
  • Biginelli
  • Biocatalysis
  • Drug discovery
  • Flow chemistry
  • Green chemistry
  • Hantzsch
  • Isocyanide
  • Mannich
  • Mechanisms
  • Multicomponent reactions
  • Passerini
  • Petasis
  • Selectivity
  • Strecker
  • Ugi

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