Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones

Art Kruithof, Marten L Ploeger, Elwin Janssen, Madeleine Helliwell, Frans J J de Kanter, Eelco Ruijter, Romano V A Orru

Research output: Contribution to JournalArticleAcademicpeer-review

183 Downloads (Pure)


Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic intermediates towards thioureas and amidines. We now report the multicomponent reaction (MCR) of in situ-generated 1-azadienes with carbon disulfide. With this reaction, a one-step protocol towards the potentially interesting 3,6-dihydro-2H-1,3-thiazine-2-thiones was established and a small library was synthesized.

Original languageEnglish
Pages (from-to)1675-1685
Number of pages11
Issue number2
Publication statusPublished - 8 Feb 2012


  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Thiazines/chemical synthesis
  • Thiones/chemical synthesis


Dive into the research topics of 'Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones'. Together they form a unique fingerprint.

Cite this