Multicomponent Synthesis of N-Heterocyclic Carbene Complexes

R.S. Bon, F.J.J. de Kanter, M. Lutz, A.L Spek, M.C. Jahnke, F.E. Hahn, M.B. Groen, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

N-Heterocyclic carbenes (NHCs) are valuable ligands in transition metal catalysis, due to their unique electronic properties. However, only a few routes toward unsymmetrically substituted, saturated NHCs are known. We have successfully applied the multicomponent synthesis of 2H-2-imidazolines for the preparation of a range of diversely substituted imidazolidin-2-ylidene complexes under mild conditions. In the desired NHC precursors the substituents at N-1, N-3, C-4, and C-5 were varied easily and independently by choosing the appropriate amine, aldehyde, isocyanide, or halide as starting material. Subsequent formation of the imidazolium salts followed by deprotonation with KO
Original languageEnglish
Pages (from-to)3639-3650
JournalOrganometallics
Volume26
DOIs
Publication statusPublished - 2007

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