Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study

K.E. van Sluis; R.J.J.H. van Son; L. van der Molen; A.J. MCGuinness; C.E. Palme; D. Novakovic; D. Stone; L. Natsis; E. Charters; K. Jones; R. Dirven; M.W.M. van den Brekel

doi:10.1007/s00405-020-06216-z

Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study

K.E. van Sluis, R.J.J.H. van Son, L. van der Molen, A.J. MCGuinness, C.E. Palme, D. Novakovic, D. Stone, L. Natsis, E. Charters, K. Jones, R. Dirven, M.W.M. van den Brekel

Maxillofacial Surgery (AMC)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose
The purpose of this study is to assess the general course of acoustic, patient rated, and clinician-rated voice outcomes from pre- up to 12 months post total laryngectomy.

Methods
Patients admitted to a total laryngectomy in five participating hospitals in Australia and The Netherlands were included. Assessments took place at pre-, 3 months, 6 months, and 12 months post-surgery. Voice outcomes are evaluated with the Acoustic Voice Quality Index (AVQI), perceptual scales, and patient-reported outcome measures including VHI-10 and EQ-5D-5L. Statistical analyses include descriptive statistics, t tests (pre- to 6 months post-surgery), Linear Mixed Effect models.

Results
The study included 43 participants. A significant worsening of AVQI is seen from pre- to post-surgery evaluated with t test (p < 0.001). The Linear Mixed Effect model confirmed Time as a significant factor in predicting AVQI score (p ≤ 0.001), as well as perceptual rated voice quality by the clinician (p = 0.015) and patient-reported perceptual rated voice quality (p = 0.002). No statistical significance was found in VHI-10 scores over time.

Conclusion
Successful TE-speech was achieved in most participants, some had to rely on augmentative alternative communication methods. Patient-reported outcomes indicate acceptance of the condition and sufficient coping in the long term. However, acoustic rated voice quality is abnormal at all post-surgery time-points. AVQI proved to be a useful instrument to evaluate TE-speech. There is a need for validation and determination of cut-off values for VHI-10 and AVQI for use in TE-speech.

Original language	English
Pages (from-to)	1209–1222
Number of pages	14
Journal	European Archives of Oto-Rhino-Laryngology
Volume	278
Issue number	4
Early online date	21 Jul 2020
DOIs	https://doi.org/10.1007/s00405-020-06216-z
Publication status	Published - Apr 2021

Funding

The authors acknowledge Atos medical AB (Malmö, Sweden) for their research grant, which contributes to the existing infrastructure for quality of life research of the Department of Head and Neck Oncology and Surgery at The Netherlands Cancer Institute. Anne Kornman, Merel Latenstein, Nadya van Gent, Katrina Moore, Jodi Gibson, Amy Freeman-Sanderson, Elizabeth Walker, Anne Taranto, and Tia Croft are acknowledged for the support they provided to implement the study procedures as well as their contribution towards the data collection. The Netherlands Cancer Institute receives a research grant from Atos Medical (Malmö, Sweden), which contributes to the existing infrastructure for quality of life research of the Department of Head and Neck Oncology and Surgery. Acknowledgements

Funders	Funder number
Atos Medical AB
Netherlands Cancer Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00405-020-06216-zLicence: CC BY

https://hdl.handle.net/11245.1/aef75745-0316-4009-945f-86276cc26a59

Persistent URL (handle)

Copy link address

Cite this

van Sluis, K. E., van Son, R. J. J. H., van der Molen, L., MCGuinness, A. J., Palme, C. E., Novakovic, D., Stone, D., Natsis, L., Charters, E., Jones, K., Dirven, R., & van den Brekel, M. W. M. (2021). Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study. European Archives of Oto-Rhino-Laryngology, 278(4), 1209–1222. https://doi.org/10.1007/s00405-020-06216-z

@article{8945cc9bc4d14b8abdd45f40b6298aff,

title = "Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study",

abstract = "PurposeThe purpose of this study is to assess the general course of acoustic, patient rated, and clinician-rated voice outcomes from pre- up to 12 months post total laryngectomy.MethodsPatients admitted to a total laryngectomy in five participating hospitals in Australia and The Netherlands were included. Assessments took place at pre-, 3 months, 6 months, and 12 months post-surgery. Voice outcomes are evaluated with the Acoustic Voice Quality Index (AVQI), perceptual scales, and patient-reported outcome measures including VHI-10 and EQ-5D-5L. Statistical analyses include descriptive statistics, t tests (pre- to 6 months post-surgery), Linear Mixed Effect models.ResultsThe study included 43 participants. A significant worsening of AVQI is seen from pre- to post-surgery evaluated with t test (p < 0.001). The Linear Mixed Effect model confirmed Time as a significant factor in predicting AVQI score (p ≤ 0.001), as well as perceptual rated voice quality by the clinician (p = 0.015) and patient-reported perceptual rated voice quality (p = 0.002). No statistical significance was found in VHI-10 scores over time.ConclusionSuccessful TE-speech was achieved in most participants, some had to rely on augmentative alternative communication methods. Patient-reported outcomes indicate acceptance of the condition and sufficient coping in the long term. However, acoustic rated voice quality is abnormal at all post-surgery time-points. AVQI proved to be a useful instrument to evaluate TE-speech. There is a need for validation and determination of cut-off values for VHI-10 and AVQI for use in TE-speech.",

author = "{van Sluis}, K.E. and {van Son}, R.J.J.H. and {van der Molen}, L. and A.J. MCGuinness and C.E. Palme and D. Novakovic and D. Stone and L. Natsis and E. Charters and K. Jones and R. Dirven and {van den Brekel}, M.W.M.",

year = "2021",

month = apr,

doi = "10.1007/s00405-020-06216-z",

language = "English",

volume = "278",

pages = "1209–1222",

journal = "European Archives of Oto-Rhino-Laryngology",

issn = "0937-4477",

publisher = "Springer Verlag",

number = "4",

}

van Sluis, KE, van Son, RJJH, van der Molen, L, MCGuinness, AJ, Palme, CE, Novakovic, D, Stone, D, Natsis, L, Charters, E, Jones, K, Dirven, R & van den Brekel, MWM 2021, 'Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study', European Archives of Oto-Rhino-Laryngology, vol. 278, no. 4, pp. 1209–1222. https://doi.org/10.1007/s00405-020-06216-z

TY - JOUR

T1 - Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study

AU - van Sluis, K.E.

AU - van Son, R.J.J.H.

AU - van der Molen, L.

AU - MCGuinness, A.J.

AU - Palme, C.E.

AU - Novakovic, D.

AU - Stone, D.

AU - Natsis, L.

AU - Charters, E.

AU - Jones, K.

AU - Dirven, R.

AU - van den Brekel, M.W.M.

PY - 2021/4

Y1 - 2021/4

N2 - PurposeThe purpose of this study is to assess the general course of acoustic, patient rated, and clinician-rated voice outcomes from pre- up to 12 months post total laryngectomy.MethodsPatients admitted to a total laryngectomy in five participating hospitals in Australia and The Netherlands were included. Assessments took place at pre-, 3 months, 6 months, and 12 months post-surgery. Voice outcomes are evaluated with the Acoustic Voice Quality Index (AVQI), perceptual scales, and patient-reported outcome measures including VHI-10 and EQ-5D-5L. Statistical analyses include descriptive statistics, t tests (pre- to 6 months post-surgery), Linear Mixed Effect models.ResultsThe study included 43 participants. A significant worsening of AVQI is seen from pre- to post-surgery evaluated with t test (p < 0.001). The Linear Mixed Effect model confirmed Time as a significant factor in predicting AVQI score (p ≤ 0.001), as well as perceptual rated voice quality by the clinician (p = 0.015) and patient-reported perceptual rated voice quality (p = 0.002). No statistical significance was found in VHI-10 scores over time.ConclusionSuccessful TE-speech was achieved in most participants, some had to rely on augmentative alternative communication methods. Patient-reported outcomes indicate acceptance of the condition and sufficient coping in the long term. However, acoustic rated voice quality is abnormal at all post-surgery time-points. AVQI proved to be a useful instrument to evaluate TE-speech. There is a need for validation and determination of cut-off values for VHI-10 and AVQI for use in TE-speech.

AB - PurposeThe purpose of this study is to assess the general course of acoustic, patient rated, and clinician-rated voice outcomes from pre- up to 12 months post total laryngectomy.MethodsPatients admitted to a total laryngectomy in five participating hospitals in Australia and The Netherlands were included. Assessments took place at pre-, 3 months, 6 months, and 12 months post-surgery. Voice outcomes are evaluated with the Acoustic Voice Quality Index (AVQI), perceptual scales, and patient-reported outcome measures including VHI-10 and EQ-5D-5L. Statistical analyses include descriptive statistics, t tests (pre- to 6 months post-surgery), Linear Mixed Effect models.ResultsThe study included 43 participants. A significant worsening of AVQI is seen from pre- to post-surgery evaluated with t test (p < 0.001). The Linear Mixed Effect model confirmed Time as a significant factor in predicting AVQI score (p ≤ 0.001), as well as perceptual rated voice quality by the clinician (p = 0.015) and patient-reported perceptual rated voice quality (p = 0.002). No statistical significance was found in VHI-10 scores over time.ConclusionSuccessful TE-speech was achieved in most participants, some had to rely on augmentative alternative communication methods. Patient-reported outcomes indicate acceptance of the condition and sufficient coping in the long term. However, acoustic rated voice quality is abnormal at all post-surgery time-points. AVQI proved to be a useful instrument to evaluate TE-speech. There is a need for validation and determination of cut-off values for VHI-10 and AVQI for use in TE-speech.

U2 - 10.1007/s00405-020-06216-z

DO - 10.1007/s00405-020-06216-z

M3 - Article

C2 - 32696251

SN - 0937-4477

VL - 278

SP - 1209

EP - 1222

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

IS - 4

ER -

Multidimensional evaluation of voice outcomes following total laryngectomy: a prospective multicenter cohort study

Abstract

Funding

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this