Abstract
Systematic behavioral phenotyping of genetically modified mice is a reliable method that can be used to detect the molecular factors involved in animals’ behavior, with translational relevance for neuropsychiatric disorders. In this thesis, we performed an in-depth behavioral analysis of four putative animal models of schizophrenia. We studied three genetic models (DISC1, ErbB4 KO & CNVs microdeletion models) that mimic disease-associated gene mutations and one biological model that mimics a dysfunction in the GABAergic system, thought to be associated with schizophrenia pathophysiology.
Original language | English |
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Qualification | PhD |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 11 Jan 2021 |
Publication status | Published - 11 Jan 2021 |
Keywords
- Schizophrenia; DISC1; ERBb4 signaling; 1q21
- 15q13.3 and 22q11.2
- microdeletions; PV+
- interneurons;