Systematic behavioral phenotyping of genetically modified mice is a reliable method that can be used to detect the molecular factors involved in animals’ behavior, with translational relevance for neuropsychiatric disorders. In this thesis, we performed an in-depth behavioral analysis of four putative animal models of schizophrenia. We studied three genetic models (DISC1, ErbB4 KO & CNVs microdeletion models) that mimic disease-associated gene mutations and one biological model that mimics a dysfunction in the GABAergic system, thought to be associated with schizophrenia pathophysiology.
|11 Jan 2021
|Published - 11 Jan 2021
- Schizophrenia; DISC1; ERBb4 signaling; 1q21
- 15q13.3 and 22q11.2
- microdeletions; PV+