Multifaceted schizophrenia: Differences and similarities in (chemo)genetic mouse models

E. Marchisella

Research output: PhD ThesisPhD-Thesis - Research and graduation internal

150 Downloads (Pure)

Abstract

Systematic behavioral phenotyping of genetically modified mice is a reliable method that can be used to detect the molecular factors involved in animals’ behavior, with translational relevance for neuropsychiatric disorders. In this thesis, we performed an in-depth behavioral analysis of four putative animal models of schizophrenia. We studied three genetic models (DISC1, ErbB4 KO & CNVs microdeletion models) that mimic disease-associated gene mutations and one biological model that mimics a dysfunction in the GABAergic system, thought to be associated with schizophrenia pathophysiology.
Original languageEnglish
QualificationPhD
Awarding Institution
  • Vrije Universiteit Amsterdam
Supervisors/Advisors
  • Spijker, S, Supervisor
  • Loos, Maarten, Co-supervisor, External person
Award date11 Jan 2021
Publication statusPublished - 11 Jan 2021

Keywords

  • Schizophrenia; DISC1; ERBb4 signaling; 1q21
  • 15q13.3 and 22q11.2
  • microdeletions; PV+
  • interneurons;

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