Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living

TOPICS-MDS Consortium

doi:10.1016/j.archger.2023.105134

Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living

TOPICS-MDS Consortium

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.

Original language	English
Article number	105134
Pages (from-to)	1-7
Number of pages	7
Journal	Archives of Gerontology and Geriatrics
Volume	115
Early online date	20 Jul 2023
DOIs	https://doi.org/10.1016/j.archger.2023.105134
Publication status	Published - Dec 2023

Bibliographical note

Funding Information:
ZonMw (The Dutch Organization for Health Research and Development; Grant reference: 633400002). The financial sponsor had no role in the design, methods, subject recruitment, data collection, analysis or preparation of this manuscript. The authors thank TOPICS-MDS Consortium members for their contribution to this research. TOPICS-MDS Consortium: Project Group N Bleijenberg (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands); JW Blom (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); S Metzelthin (CAPHRI School for Public Health and Primary Care, Dept. of Health Services Research, Maastricht University, Netherlands), PFM Krabbe (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Netherlands); RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); ME Muntinga (Department of General Practice and Elderly Care Medicine/EMGO + Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands); EW Steyerberg (Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands); Steering Committee BM Buurman (Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, Netherlands), J Gussekloo (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); HE van der Horst (Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical center Amsterdam, Netherlands); MGM Olde-Rikkert, (Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); SEJA de Rooij (University Center for Geriatric Medicine, University Medical Center, Groningen, Netherlands); JMGA Schols (Department of Family Medicine and Dept. of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands); MJ Schuurmans (Department of Rehabilitation, Nursing Science & Sports, University Medical Center Utrecht, Netherlands); DA Smilde (GENERO Foundation, Rotterdam, Netherlands); Working group member: F Leeuwis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands).

Publisher Copyright:
© 2023

Funding

ZonMw (The Dutch Organization for Health Research and Development; Grant reference: 633400002). The financial sponsor had no role in the design, methods, subject recruitment, data collection, analysis or preparation of this manuscript. The authors thank TOPICS-MDS Consortium members for their contribution to this research. TOPICS-MDS Consortium: Project Group N Bleijenberg (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands); JW Blom (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); S Metzelthin (CAPHRI School for Public Health and Primary Care, Dept. of Health Services Research, Maastricht University, Netherlands), PFM Krabbe (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Netherlands); RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); ME Muntinga (Department of General Practice and Elderly Care Medicine/EMGO + Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands); EW Steyerberg (Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands); Steering Committee BM Buurman (Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, Netherlands), J Gussekloo (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); HE van der Horst (Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical center Amsterdam, Netherlands); MGM Olde-Rikkert, (Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); SEJA de Rooij (University Center for Geriatric Medicine, University Medical Center, Groningen, Netherlands); JMGA Schols (Department of Family Medicine and Dept. of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands); MJ Schuurmans (Department of Rehabilitation, Nursing Science & Sports, University Medical Center Utrecht, Netherlands); DA Smilde (GENERO Foundation, Rotterdam, Netherlands); Working group member: F Leeuwis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands).

Funders	Funder number
Department of Family Medicine and Dept. of Health Services Research
Department of Geriatric Medicine, Radboud University Medical Center
Dept. of Geriatric Medicine, Radboud University Medical Center
Dutch Organization for Health Research and Development	633400002
EMGO Institute for health and care research
Elderly Care Medicine
Erasmus MC University Medical Center
PFM Krabbe (Department of Epidemiology
RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center
SEJA de Rooij
Steering Committee BM Buurman
Illinois Department of Public Health
Amsterdam University Medical Centers
Rijksuniversiteit Groningen
ZonMw
Leids Universitair Medisch Centrum
Universitair Medisch Centrum Groningen
Care and Public Health Research Institute, Universiteit Maastricht

Keywords

ADLs
EQ-5D
Latent class analysis
Multimorbidity
Quality of life

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10.1016/j.archger.2023.105134

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Cite this

@article{730cb0b5b81c4570a6cec82ca1302685,

title = "Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living",

abstract = "Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.",

keywords = "ADLs, EQ-5D, Latent class analysis, Multimorbidity, Quality of life",

author = "Lutomski, \{Jennifer E.\} and Trynke Hoekstra and Akker, \{Marjan van den\} and Jeanet Blom and Amaia Calder{\'o}n-Larra{\~n}aga and Alessandra Marengoni and Alexandra Prados-Torres and Marcel Olde-Rikkert and Rene Melis and \{TOPICS-MDS Consortium\}",

note = "Funding Information: ZonMw (The Dutch Organization for Health Research and Development; Grant reference: 633400002). The financial sponsor had no role in the design, methods, subject recruitment, data collection, analysis or preparation of this manuscript. The authors thank TOPICS-MDS Consortium members for their contribution to this research. TOPICS-MDS Consortium: Project Group N Bleijenberg (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands); JW Blom (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); S Metzelthin (CAPHRI School for Public Health and Primary Care, Dept. of Health Services Research, Maastricht University, Netherlands), PFM Krabbe (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Netherlands); RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); ME Muntinga (Department of General Practice and Elderly Care Medicine/EMGO + Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands); EW Steyerberg (Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands); Steering Committee BM Buurman (Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, Netherlands), J Gussekloo (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); HE van der Horst (Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical center Amsterdam, Netherlands); MGM Olde-Rikkert, (Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); SEJA de Rooij (University Center for Geriatric Medicine, University Medical Center, Groningen, Netherlands); JMGA Schols (Department of Family Medicine and Dept. of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands); MJ Schuurmans (Department of Rehabilitation, Nursing Science \& Sports, University Medical Center Utrecht, Netherlands); DA Smilde (GENERO Foundation, Rotterdam, Netherlands); Working group member: F Leeuwis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands). Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = dec,

doi = "10.1016/j.archger.2023.105134",

language = "English",

volume = "115",

pages = "1--7",

journal = "Archives of Gerontology and Geriatrics",

issn = "0167-4943",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living

AU - Lutomski, Jennifer E.

AU - Hoekstra, Trynke

AU - Akker, Marjan van den

AU - Blom, Jeanet

AU - Calderón-Larrañaga, Amaia

AU - Marengoni, Alessandra

AU - Prados-Torres, Alexandra

AU - Olde-Rikkert, Marcel

AU - Melis, Rene

AU - TOPICS-MDS Consortium

N1 - Funding Information: ZonMw (The Dutch Organization for Health Research and Development; Grant reference: 633400002). The financial sponsor had no role in the design, methods, subject recruitment, data collection, analysis or preparation of this manuscript. The authors thank TOPICS-MDS Consortium members for their contribution to this research. TOPICS-MDS Consortium: Project Group N Bleijenberg (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands); JW Blom (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); S Metzelthin (CAPHRI School for Public Health and Primary Care, Dept. of Health Services Research, Maastricht University, Netherlands), PFM Krabbe (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Netherlands); RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); ME Muntinga (Department of General Practice and Elderly Care Medicine/EMGO + Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands); EW Steyerberg (Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands); Steering Committee BM Buurman (Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, Netherlands), J Gussekloo (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); HE van der Horst (Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical center Amsterdam, Netherlands); MGM Olde-Rikkert, (Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); SEJA de Rooij (University Center for Geriatric Medicine, University Medical Center, Groningen, Netherlands); JMGA Schols (Department of Family Medicine and Dept. of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands); MJ Schuurmans (Department of Rehabilitation, Nursing Science & Sports, University Medical Center Utrecht, Netherlands); DA Smilde (GENERO Foundation, Rotterdam, Netherlands); Working group member: F Leeuwis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands). Publisher Copyright: © 2023

PY - 2023/12

Y1 - 2023/12

N2 - Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.

AB - Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.

KW - ADLs

KW - EQ-5D

KW - Latent class analysis

KW - Multimorbidity

KW - Quality of life

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UR - https://www.scopus.com/pages/publications/85165911155#tab=citedBy

U2 - 10.1016/j.archger.2023.105134

DO - 10.1016/j.archger.2023.105134

M3 - Article

SN - 0167-4943

VL - 115

SP - 1

EP - 7

JO - Archives of Gerontology and Geriatrics

JF - Archives of Gerontology and Geriatrics

M1 - 105134

ER -

Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

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