Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkes ophthalmic acid and 5-oxoproline in humans and rats

S. Geenen, J.W.T. Yates, J.G. Kenna, F.Y. Bois, I.D. Wilson, H.V. Westerhoff

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