TY - JOUR
T1 - Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
AU - Park, Bo-yong
AU - Kebets, Valeria
AU - Larivière, Sara
AU - Hettwer, Meike D.
AU - Paquola, Casey
AU - van Rooij, Daan
AU - Buitelaar, Jan
AU - Franke, Barbara
AU - Hoogman, Martine
AU - Schmaal, Lianne
AU - Veltman, Dick J.
AU - van den Heuvel, Odile A.
AU - Stein, Dan J.
AU - Andreassen, Ole A.
AU - Ching, Christopher R. K.
AU - Turner, Jessica A.
AU - van Erp, Theo G. M.
AU - Evans, Alan C.
AU - Dagher, Alain
AU - Thomopoulos, Sophia I.
AU - Thompson, Paul M.
AU - Valk, Sofie L.
AU - Kirschner, Matthias
AU - Bernhardt, Boris C.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we identified a cortex-wide dimension of morphological changes that described a sensory-fugal pattern, with paralimbic regions showing the most consistent alterations across conditions. The shared disease dimension was closely related to cortical gradients of microstructure as well as neurotransmitter axes, specifically cortex-wide variations in serotonin and dopamine. Multiple sensitivity analyses confirmed robustness with respect to slight variations in analytical choices. Our findings embed shared effects of common psychiatric conditions on brain structure in multiple scales of brain organization, and may provide insights into neural mechanisms of transdiagnostic vulnerability.
AB - It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we identified a cortex-wide dimension of morphological changes that described a sensory-fugal pattern, with paralimbic regions showing the most consistent alterations across conditions. The shared disease dimension was closely related to cortical gradients of microstructure as well as neurotransmitter axes, specifically cortex-wide variations in serotonin and dopamine. Multiple sensitivity analyses confirmed robustness with respect to slight variations in analytical choices. Our findings embed shared effects of common psychiatric conditions on brain structure in multiple scales of brain organization, and may provide insights into neural mechanisms of transdiagnostic vulnerability.
UR - http://www.scopus.com/inward/record.url?scp=85138981157&partnerID=8YFLogxK
U2 - 10.1038/s42003-022-03963-z
DO - 10.1038/s42003-022-03963-z
M3 - Article
SN - 2399-3642
VL - 5
JO - Communications biology
JF - Communications biology
IS - 1
M1 - 1024
ER -