Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

E. Oh; M.A. Kalwat; M.J. Kim; M. Verhage; D.C. Thurmond

doi:10.1074/jbc.M112.361501

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

E. Oh, M.A. Kalwat, M.J. Kim, M. Verhage, D.C. Thurmond

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Attenuated levels of the Sec1/Munc18 (SM) protein Munc18-1 in human islet β-cells is coincident with type 2 diabetes, although how Munc18-1 facilitates insulin secretion remains enigmatic. Herein, using conventional Munc18-1

Original language	English
Pages (from-to)	25821-25833
Journal	Journal of Biological Chemistry
Volume	287
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M112.361501
Publication status	Published - 2012

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10.1074/jbc.M112.361501

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title = "Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms",

abstract = "Attenuated levels of the Sec1/Munc18 (SM) protein Munc18-1 in human islet β-cells is coincident with type 2 diabetes, although how Munc18-1 facilitates insulin secretion remains enigmatic. Herein, using conventional Munc18-1",

author = "E. Oh and M.A. Kalwat and M.J. Kim and M. Verhage and D.C. Thurmond",

year = "2012",

doi = "10.1074/jbc.M112.361501",

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AU - Oh, E.

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AU - Verhage, M.

AU - Thurmond, D.C.

PY - 2012

Y1 - 2012

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AB - Attenuated levels of the Sec1/Munc18 (SM) protein Munc18-1 in human islet β-cells is coincident with type 2 diabetes, although how Munc18-1 facilitates insulin secretion remains enigmatic. Herein, using conventional Munc18-1

U2 - 10.1074/jbc.M112.361501

DO - 10.1074/jbc.M112.361501

M3 - Article

SN - 0021-9258

VL - 287

SP - 25821

EP - 25833

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

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