Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

Jeanine M Van Ancum; Kira Scheerman; Vincent D Pierik; Siger T Numans; Sjors Verlaan; Hanne E. Smeenk; Monique Slee-Valentijn; Roeliene C. Kruizinga; Carel G M Meskers; Andrea B Maier

doi:10.1159/000478777

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

Jeanine M Van Ancum, Kira Scheerman, Vincent D Pierik, Siger T Numans, Sjors Verlaan, Hanne E. Smeenk, Monique Slee-Valentijn, Roeliene C. Kruizinga, Carel G M Meskers, Andrea B Maier

Biomechanics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear.

OBJECTIVE: We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions.

METHODS: The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed.

RESULTS: A total of 373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions.

DISCUSSION: Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization.

Original language	English
Pages (from-to)	507-514
Number of pages	8
Journal	Gerontology
Volume	63
Issue number	6
Early online date	18 Aug 2017
DOIs	https://doi.org/10.1159/000478777
Publication status	Published - 1 Oct 2017

Funding

This work was supported by the seventh framework program MYOAGE (HEALTH-2007-2.4.5-10) and European Union’s Horizon 2020 research and innovation programme (689238, 675003), and Nutricia Research, Nutricia Advanced Medical Nutrition, The Netherlands.

Funders	Funder number
European Union’s Horizon 2020 research and innovation programme	689238, 675003
Seventh Framework Programme	HEALTH-2007-2.4.5-10
Nutricia Research Foundation

Keywords

Age-related changes
Geriatric medicine
Journal Article
Muscle
Muscle strength
Sarcopenia
old age
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000478777

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title = "Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study",

abstract = "BACKGROUND: Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear.OBJECTIVE: We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions.METHODS: The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed.RESULTS: A total of 373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions.DISCUSSION: Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization.",

keywords = "Age-related changes, Geriatric medicine, Journal Article, Muscle, Muscle strength, Sarcopenia, old age, risk factors",

author = "{Van Ancum}, {Jeanine M} and Kira Scheerman and Pierik, {Vincent D} and Numans, {Siger T} and Sjors Verlaan and Smeenk, {Hanne E.} and Monique Slee-Valentijn and Kruizinga, {Roeliene C.} and Meskers, {Carel G M} and Maier, {Andrea B}",

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doi = "10.1159/000478777",

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T1 - Muscle Strength and Muscle Mass in Older Patients during Hospitalization

T2 - The EMPOWER Study

AU - Van Ancum, Jeanine M

AU - Scheerman, Kira

AU - Pierik, Vincent D

AU - Numans, Siger T

AU - Verlaan, Sjors

AU - Smeenk, Hanne E.

AU - Slee-Valentijn, Monique

AU - Kruizinga, Roeliene C.

AU - Meskers, Carel G M

AU - Maier, Andrea B

PY - 2017/10/1

Y1 - 2017/10/1

N2 - BACKGROUND: Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear.OBJECTIVE: We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions.METHODS: The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed.RESULTS: A total of 373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions.DISCUSSION: Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization.

AB - BACKGROUND: Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear.OBJECTIVE: We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions.METHODS: The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed.RESULTS: A total of 373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions.DISCUSSION: Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization.

KW - Age-related changes

KW - Geriatric medicine

KW - Journal Article

KW - Muscle

KW - Muscle strength

KW - Sarcopenia

KW - old age

KW - risk factors

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DO - 10.1159/000478777

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SN - 0304-324X

VL - 63

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JO - Gerontology

JF - Gerontology

IS - 6

ER -

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

Abstract

Funding

Keywords

UN SDGs

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