Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

E.R. Witjas-Paalberends; N. Piroddi; C.J. Stam; S.J. van Dijk; V.S. Oliviera; C. Ferrara; B. Scellini; M. Hazebroek; F.J. ten Cate; M. van Slegtenhorst; C. dos Remedios; H.W.M. Niessen; C. Tesi; G.J.M. Stienen; S. Heymans; M. Michels; C. Poggesi; J. van der Velden

doi:10.1093/cvr/cvt119

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

E.R. Witjas-Paalberends, N. Piroddi, C.J. Stam, S.J. van Dijk, V.S. Oliviera, C. Ferrara, B. Scellini, M. Hazebroek, F.J. ten Cate, M. van Slegtenhorst, C. dos Remedios, H.W.M. Niessen, C. Tesi, G.J.M. Stienen, S. Heymans, M. Michels, C. Poggesi, J. van der Velden

Physics of Living Systems

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.We studied whether cellular dysfunction is due to an intrinsic sarcomere defect or cardiomyocyte remodelling. Methods and results Cardiac samples from 43 sarcomere mutation-positive patients (HCM

Original language	English
Pages (from-to)	432-441
Journal	Cardiovascular Research
Volume	99
Issue number	3
DOIs	https://doi.org/10.1093/cvr/cvt119
Publication status	Published - 2013

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Witjas-Paalberends, E. R., Piroddi, N., Stam, C. J., van Dijk, S. J., Oliviera, V. S., Ferrara, C., Scellini, B., Hazebroek, M., ten Cate, F. J., van Slegtenhorst, M., dos Remedios, C., Niessen, H. W. M., Tesi, C., Stienen, G. J. M., Heymans, S., Michels, M., Poggesi, C., & van der Velden, J. (2013). Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy. Cardiovascular Research, 99(3), 432-441. https://doi.org/10.1093/cvr/cvt119

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title = "Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy",

abstract = "Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.We studied whether cellular dysfunction is due to an intrinsic sarcomere defect or cardiomyocyte remodelling. Methods and results Cardiac samples from 43 sarcomere mutation-positive patients (HCM",

author = "E.R. Witjas-Paalberends and N. Piroddi and C.J. Stam and {van Dijk}, S.J. and V.S. Oliviera and C. Ferrara and B. Scellini and M. Hazebroek and {ten Cate}, F.J. and {van Slegtenhorst}, M. and {dos Remedios}, C. and H.W.M. Niessen and C. Tesi and G.J.M. Stienen and S. Heymans and M. Michels and C. Poggesi and {van der Velden}, J.",

year = "2013",

doi = "10.1093/cvr/cvt119",

language = "English",

volume = "99",

pages = "432--441",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "3",

}

Witjas-Paalberends, ER, Piroddi, N, Stam, CJ, van Dijk, SJ, Oliviera, VS, Ferrara, C, Scellini, B, Hazebroek, M, ten Cate, FJ, van Slegtenhorst, M, dos Remedios, C, Niessen, HWM, Tesi, C, Stienen, GJM, Heymans, S, Michels, M, Poggesi, C & van der Velden, J 2013, 'Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy', Cardiovascular Research, vol. 99, no. 3, pp. 432-441. https://doi.org/10.1093/cvr/cvt119

TY - JOUR

T1 - Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

AU - Witjas-Paalberends, E.R.

AU - Piroddi, N.

AU - Stam, C.J.

AU - van Dijk, S.J.

AU - Oliviera, V.S.

AU - Ferrara, C.

AU - Scellini, B.

AU - Hazebroek, M.

AU - ten Cate, F.J.

AU - van Slegtenhorst, M.

AU - dos Remedios, C.

AU - Niessen, H.W.M.

AU - Tesi, C.

AU - Stienen, G.J.M.

AU - Heymans, S.

AU - Michels, M.

AU - Poggesi, C.

AU - van der Velden, J.

PY - 2013

Y1 - 2013

N2 - Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.We studied whether cellular dysfunction is due to an intrinsic sarcomere defect or cardiomyocyte remodelling. Methods and results Cardiac samples from 43 sarcomere mutation-positive patients (HCM

AB - Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.We studied whether cellular dysfunction is due to an intrinsic sarcomere defect or cardiomyocyte remodelling. Methods and results Cardiac samples from 43 sarcomere mutation-positive patients (HCM

U2 - 10.1093/cvr/cvt119

DO - 10.1093/cvr/cvt119

M3 - Article

SN - 0008-6363

VL - 99

SP - 432

EP - 441

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

Abstract

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