Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data

D. Posthuma; D.I. Boomsma

doi:10.1007/s10519-005-2791-5

Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data

D. Posthuma, D.I. Boomsma

Biological Psychology

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Abstract

Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/ or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library ( http://www.psy.vu.nl/mxbib ) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives. © 2005 Springer Science+Business Media, Inc.

Original language	English
Pages (from-to)	499-505
Journal	Behavior Genetics
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s10519-005-2791-5
Publication status	Published - 2005

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Netherlands Twin Register (NTR)

UN SDGs

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10.1007/s10519-005-2791-5

Posthuma Behavior Genetics 35(4) 2005 uFinal published version, 158 KB

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR_publicaties_2005/Posthuma_MXLibrary_BG2005.pdf

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AB - Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/ or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library ( http://www.psy.vu.nl/mxbib ) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives. © 2005 Springer Science+Business Media, Inc.

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Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data

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UN SDGs

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