Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data

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Abstract

Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/ or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library ( http://www.psy.vu.nl/mxbib ) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives. © 2005 Springer Science+Business Media, Inc.
Original languageEnglish
Pages (from-to)499-505
JournalBehavior Genetics
Volume35
Issue number4
DOIs
Publication statusPublished - 2005

Cohort Studies

  • Netherlands Twin Register (NTR)

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