Nanobodies targeting and modulating CXCR4 and ACKR3

V. Bobkov

Research output: PhD Thesis › PhD Thesis - Research VU Amsterdam, graduation VU Amsterdam

105 Downloads (Pure)

Original language	English
Qualification	PhD
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Smit, M.J., Supervisor, External person De Haard, H., Supervisor, External person Heukers, R., Co-supervisor Van Der Woning, B., Co-supervisor, External person
Award date	26 Feb 2021
Publication status	Published - 2021

Access to Document

coverFinal published version, 502 KB
title pageFinal published version, 182 KB
abstract dutchFinal published version, 257 KB
abstract englishFinal published version, 874 KB
table of contentsFinal published version, 598 KB
chapter 1 Introduction and aim of the thesisFinal published version, 8.66 MB
chapter 2 Antibodies targeting chemokine receptors CXCR4 and ACKR3Final published version, 10 MB
chapter 3 Display technologies for generation of Ig single variable domainsFinal published version, 6.9 MB
chapter 4 CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entryFinal published version, 12.7 MB
chapter 6 Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-medFinal published version, 11.4 MB
chapter 8 Discussion and future perspectivesFinal published version, 12.9 MB
chapter ReferencesFinal published version, 9.94 MB
chapter References continueFinal published version, 11.1 MB

Embargoed Document

chapter 5 TR-FRET between engineered nanobodies reveals existence of endogenous CXCR4 oligomers
Final published version, 15.1 MB
Embargo ends: 26/08/22

Embargoed Document

chapter 7 Contribution of CXCR4 and ACKR3 to tumor growth in a syngeneic in vivo colon cancer model
Final published version, 10.4 MB
Embargo ends: 26/08/22

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