Nanoswitches based on DNA base pairs: why adenine-thymine is less suitable than guanine-cytosine

C. Fonseca Guerra; T. van der Wijst; F.M. Bickelhaupt

doi:10.1002/cphc.200600216

Nanoswitches based on DNA base pairs: why adenine-thymine is less suitable than guanine-cytosine

C. Fonseca Guerra, T. van der Wijst, F.M. Bickelhaupt

Theoretical Chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Substituted Watson-Crick guanine-cytosine (GC) base pairs were recently shown to yield robust three-state nanoswitches. Here, we address the question: Can such supramolecular switches also be based on Watson-Crick adenine-thymine (AT) base pairs? We have theoretically analyzed AT pairs in which purine-C8 and/or pyrimidine-C6 positions carry a substituent X-NH

Original language	English
Pages (from-to)	1971-9
Journal	ChemPhysChem
Volume	7
Issue number	9
DOIs	https://doi.org/10.1002/cphc.200600216
Publication status	Published - 2006

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title = "Nanoswitches based on DNA base pairs: why adenine-thymine is less suitable than guanine-cytosine",

abstract = "Substituted Watson-Crick guanine-cytosine (GC) base pairs were recently shown to yield robust three-state nanoswitches. Here, we address the question: Can such supramolecular switches also be based on Watson-Crick adenine-thymine (AT) base pairs? We have theoretically analyzed AT pairs in which purine-C8 and/or pyrimidine-C6 positions carry a substituent X-NH",

author = "{Fonseca Guerra}, C. and {van der Wijst}, T. and F.M. Bickelhaupt",

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AU - Bickelhaupt, F.M.

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AB - Substituted Watson-Crick guanine-cytosine (GC) base pairs were recently shown to yield robust three-state nanoswitches. Here, we address the question: Can such supramolecular switches also be based on Watson-Crick adenine-thymine (AT) base pairs? We have theoretically analyzed AT pairs in which purine-C8 and/or pyrimidine-C6 positions carry a substituent X-NH

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DO - 10.1002/cphc.200600216

M3 - Article

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EP - 1979

JO - ChemPhysChem

JF - ChemPhysChem

IS - 9

ER -

Nanoswitches based on DNA base pairs: why adenine-thymine is less suitable than guanine-cytosine

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