Netherlands Twin Register: From twins to twin families.

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.
Original languageEnglish
Pages (from-to)849-857
JournalTwin Research and Human Genetics
Volume9
Issue number6
DOIs
Publication statusPublished - 2006

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Netherlands
Young Adult
Siblings
Longitudinal Studies
Databases
Multiple Birth Offspring
Metabolomics
Adult Children
Psychopathology
Spouses
Neuroimaging
Epidemiologic Studies
Parents
Mothers
Urine
Interviews
Equipment and Supplies
Research

Cite this

@article{365826e9043a4e5f9de51f97bec3bc95,
title = "Netherlands Twin Register: From twins to twin families.",
abstract = "In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.",
author = "D.I. Boomsma and {de Geus}, E.J.C. and J.M. Vink and J.H. Stubbe and M.A. Distel and J.J. Hottenga and D. Posthuma and {van Beijsterveldt}, C.E.M. and J. Hudziak and M. Bartels and G. Willemsen",
year = "2006",
doi = "10.1375/183242706779462426",
language = "English",
volume = "9",
pages = "849--857",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",
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}

Netherlands Twin Register: From twins to twin families. / Boomsma, D.I.; de Geus, E.J.C.; Vink, J.M.; Stubbe, J.H.; Distel, M.A.; Hottenga, J.J.; Posthuma, D.; van Beijsterveldt, C.E.M.; Hudziak, J.; Bartels, M.; Willemsen, G.

In: Twin Research and Human Genetics, Vol. 9, No. 6, 2006, p. 849-857.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Netherlands Twin Register: From twins to twin families.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Vink, J.M.

AU - Stubbe, J.H.

AU - Distel, M.A.

AU - Hottenga, J.J.

AU - Posthuma, D.

AU - van Beijsterveldt, C.E.M.

AU - Hudziak, J.

AU - Bartels, M.

AU - Willemsen, G.

PY - 2006

Y1 - 2006

N2 - In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.

AB - In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.

U2 - 10.1375/183242706779462426

DO - 10.1375/183242706779462426

M3 - Article

VL - 9

SP - 849

EP - 857

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 6

ER -