Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration

Matteo Mancini, Marcel A. De Reus, Laura Serra, Marco Bozzali, Martijn P. Van Den Heuvel, Mara Cercignani, Silvia Conforto

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

The brain structure is a complex network of interconnected regions with specific topological characteristics. Since the disruption of this infrastructure has been linked to brain diseases, a key element to the quest for understanding how such diseases start and spread is to outline the degenerative pattern. In this paper, we explored this aspect using network attack simulation on the structural connectomes of 60 patients among Alzheimer's disease (AD) and mild cognitive impairment (MCI) and 30 healthy subjects. We considered different attack strategies and different metrics to evaluate and compare the induced changes between the different groups. We found out that patients and controls share common attack tolerance patterns in the peripheral connections compared to each other, and that hubs played analogous role in the tolerance impact. These results suggest that the spreading pattern of Alzheimer's disease does not target specific class of regions.

Original languageEnglish
Title of host publication2016 IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2016 - Proceedings
PublisherIEEE Computer Society
Pages237-240
Number of pages4
ISBN (Electronic)9781479923502
DOIs
Publication statusPublished - 15 Jun 2016
Externally publishedYes
Event2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016 - Prague, Czech Republic
Duration: 13 Apr 201616 Apr 2016

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2016-June
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016
CountryCzech Republic
CityPrague
Period13/04/1616/04/16

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Keywords

  • Alzheimer's disease
  • brain network
  • connectome
  • diffusion tractography
  • graph theory
  • network attack

Cite this

Mancini, M., De Reus, M. A., Serra, L., Bozzali, M., Van Den Heuvel, M. P., Cercignani, M., & Conforto, S. (2016). Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration. In 2016 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016 - Proceedings (pp. 237-240). [7493253] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2016-June). IEEE Computer Society. https://doi.org/10.1109/ISBI.2016.7493253