Network structure of the human musculoskeletal system shapes neural interactions on multiple time scales

Jennifer N. Kerkman, Andreas Daffertshofer, Leonardo L. Gollo, Michael Breakspear, Tjeerd W. Boonstra

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Human motor control requires the coordination of muscle activity under the anatomical constraints imposed by the musculoskeletal system. Interactions within the central nervous system are fundamental to motor coordination, but the principles governing functional integration remain poorly understood. We used network analysis to investigate the relationship between anatomical and functional connectivity among 36 muscles. Anatomical networks were defined by the physical connections between muscles, and functional networks were based on intermuscular coherence assessed during postural tasks. We found a modular structure of functional networks that was strongly shaped by the anatomical constraints of the musculoskeletal system. Changes in postural tasks were associated with a frequency-dependent reconfiguration of the coupling between functional modules. These findings reveal distinct patterns of functional interactions between muscles involved in flexibly organizing muscle activity during postural control. Our network approach to the motor system offers a unique window into the neural circuitry driving the musculoskeletal system.

Original languageEnglish
Article numbereaat0497
JournalScience advances
Volume4
Issue number6
DOIs
Publication statusPublished - 27 Jun 2018

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Musculoskeletal System
Muscles
Central Nervous System

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abstract = "Human motor control requires the coordination of muscle activity under the anatomical constraints imposed by the musculoskeletal system. Interactions within the central nervous system are fundamental to motor coordination, but the principles governing functional integration remain poorly understood. We used network analysis to investigate the relationship between anatomical and functional connectivity among 36 muscles. Anatomical networks were defined by the physical connections between muscles, and functional networks were based on intermuscular coherence assessed during postural tasks. We found a modular structure of functional networks that was strongly shaped by the anatomical constraints of the musculoskeletal system. Changes in postural tasks were associated with a frequency-dependent reconfiguration of the coupling between functional modules. These findings reveal distinct patterns of functional interactions between muscles involved in flexibly organizing muscle activity during postural control. Our network approach to the motor system offers a unique window into the neural circuitry driving the musculoskeletal system.",
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Network structure of the human musculoskeletal system shapes neural interactions on multiple time scales. / Kerkman, Jennifer N.; Daffertshofer, Andreas; Gollo, Leonardo L.; Breakspear, Michael; Boonstra, Tjeerd W.

In: Science advances, Vol. 4, No. 6, eaat0497, 27.06.2018.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Kerkman, Jennifer N.

AU - Daffertshofer, Andreas

AU - Gollo, Leonardo L.

AU - Breakspear, Michael

AU - Boonstra, Tjeerd W.

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AB - Human motor control requires the coordination of muscle activity under the anatomical constraints imposed by the musculoskeletal system. Interactions within the central nervous system are fundamental to motor coordination, but the principles governing functional integration remain poorly understood. We used network analysis to investigate the relationship between anatomical and functional connectivity among 36 muscles. Anatomical networks were defined by the physical connections between muscles, and functional networks were based on intermuscular coherence assessed during postural tasks. We found a modular structure of functional networks that was strongly shaped by the anatomical constraints of the musculoskeletal system. Changes in postural tasks were associated with a frequency-dependent reconfiguration of the coupling between functional modules. These findings reveal distinct patterns of functional interactions between muscles involved in flexibly organizing muscle activity during postural control. Our network approach to the motor system offers a unique window into the neural circuitry driving the musculoskeletal system.

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