Neural plasticity and adult neurogenesis: the deep biology perspective

Anna Colangelo, Giovanni Cirillo, Lilia Alberghina, Michele Papa, Hans Westerhoff

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology.

LanguageEnglish
Pages201-205
Number of pages5
JournalNeural Regeneration Research
Volume14
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

Fingerprint

Neuronal Plasticity
Neurogenesis
Energy Metabolism
Growth Differentiation Factors
Mitochondrial Dynamics
Developmental Biology
Neurobiology
Brain
Brain Diseases
Regeneration
Anatomy
Apoptosis
Oxygen
Research

Keywords

  • Adult brain
  • Deep biology
  • Differentiation
  • Energy homeostasis
  • Mitochondria
  • Nerve growth factor
  • Neurogenesis
  • Neuron
  • Neuroregeneration
  • Systems biology

Cite this

Colangelo, Anna ; Cirillo, Giovanni ; Alberghina, Lilia ; Papa, Michele ; Westerhoff, Hans. / Neural plasticity and adult neurogenesis : the deep biology perspective. In: Neural Regeneration Research. 2019 ; Vol. 14, No. 2. pp. 201-205.
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Neural plasticity and adult neurogenesis : the deep biology perspective. / Colangelo, Anna; Cirillo, Giovanni; Alberghina, Lilia; Papa, Michele; Westerhoff, Hans.

In: Neural Regeneration Research, Vol. 14, No. 2, 01.02.2019, p. 201-205.

Research output: Contribution to JournalReview articleAcademicpeer-review

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