Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.

M. Antoniades; I. Nenadic; T. Kircher; A. Krug; A. Fornito; U. Dannlowski; P. DeRosse; B. Baune; M. Green; Y. Quidé; C. Pantelis; R. Chan; U. Ettinger; M. Debbané; C. Gaser; B. Besteher; K. Diederen; T. Spencer; W. Rössler; V. Kumari; H. Park; I. Lemmers-Jansen; P. Allen; J.B. Marsman; J. Gilleen; M. Kirschner; A. Dagher; I. Lebedeva; S. Kaiser; A. Fett; I. Sommer; T. van Erp; J. Turner; P.M. Thompson; A. Aleman; G. Modinos for the ENIGMA Schizotypy Working Group

doi:10.1016/j.biopsych.2020.02.807

Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.

M. Antoniades
, I. Nenadic
, T. Kircher
, A. Krug
, A. Fornito
, U. Dannlowski
, P. DeRosse
, B. Baune
, M. Green
, Y. Quidé
, C. Pantelis
, R. Chan
, U. Ettinger
, M. Debbané
, C. Gaser
, B. Besteher
, K. Diederen
, T. Spencer
, W. Rössler
, V. Kumari

H. Park, I. Lemmers-Jansen, P. Allen, J.B. Marsman, J. Gilleen, M. Kirschner, A. Dagher, I. Lebedeva, S. Kaiser, A. Fett, I. Sommer, T. van Erp, J. Turner, P.M. Thompson, A. Aleman, G. Modinos for the ENIGMA Schizotypy Working Group

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Abstract

Recent meta-analytical evidence indicates that cortical thickness abnormalities in schizophrenia are influenced by illness severity and antipsychotic medication exposure. Schizotypy research allows investigating the neuroanatomical correlates of psychotic-like experiences without illness- and treatment-related confounders. Here we present the first large-scale meta-analysis of cortical thickness in schizotypy across 23 datasets worldwide.
Methods
The study involved structural MRI scans from 2,695 healthy individuals (mean [range] age, 29.1 [17-55.8], 46.3% male) who also completed self-report schizotypy questionnaires. Each site used FreeSurfer to extract cortical thickness for 70 Desikan-Killiany atlas regions (34 regions per hemisphere + left and right hemisphere mean thickness), and performed partial correlation analyses with total schizotypy scores in R to predict left, right and mean cortical thickness by region, adjusting by sex and age. Random-effects meta-analyses of partial correlation effect sizes for each region were performed using R’s metafor package.
Results
Schizotypy scores were positively associated with mean cortical thickness of the medial orbitofrontal cortex (r=0.077; pFDR=0.006) and the frontal pole (r=0.073; pFDR=0.006). By hemisphere, schizotypy was associated with cortical thickness of the left medial orbitofrontal cortex (r=0.066; pFDR=0.044), and at trend-level with the right medial orbitofrontal cortex and left frontal pole (both r=0.062; pFDR=0.053).
Conclusions
Worldwide cooperative analyses of neuroimaging data shows that subclinical psychotic-like experiences are associated with greater prefrontal cortical thickness. The directionality of the effects is opposite to that of thinner cortex in schizophrenia. Given that accelerated prefrontal thinning has been associated with progression to psychosis in at-risk individuals, our findings may reflect mechanisms of resilience in schizotypy.
Supported By
GM is supported by a Sir Henry Dale Fellowship, jointly funded by The Wellcome Trust and The Royal Society.
Keywords
Schizotypy, Psychosis, Structural MRI, ENIGMA Consortium, Neuroanatomy

Original language	English
Pages (from-to)	S313-S314
Journal	Biological Psychiatry
Volume	87
Issue number	9
DOIs	https://doi.org/10.1016/j.biopsych.2020.02.807
Publication status	Published - 2020
Externally published	Yes

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10.1016/j.biopsych.2020.02.807

Antoniades, 2020

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Antoniades, M., Nenadic, I., Kircher, T., Krug, A., Fornito, A., Dannlowski, U., DeRosse, P., Baune, B., Green, M., Quidé, Y., Pantelis, C., Chan, R., Ettinger, U., Debbané, M., Gaser, C., Besteher, B., Diederen, K., Spencer, T., Rössler, W., ... Modinos for the ENIGMA Schizotypy Working Group, G. (2020). Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium. Biological Psychiatry, 87(9), S313-S314. https://doi.org/10.1016/j.biopsych.2020.02.807

@article{46131d4527d745c08cb3100430fd6086,

title = "Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.",

abstract = "Recent meta-analytical evidence indicates that cortical thickness abnormalities in schizophrenia are influenced by illness severity and antipsychotic medication exposure. Schizotypy research allows investigating the neuroanatomical correlates of psychotic-like experiences without illness- and treatment-related confounders. Here we present the first large-scale meta-analysis of cortical thickness in schizotypy across 23 datasets worldwide. Methods The study involved structural MRI scans from 2,695 healthy individuals (mean [range] age, 29.1 [17-55.8], 46.3\% male) who also completed self-report schizotypy questionnaires. Each site used FreeSurfer to extract cortical thickness for 70 Desikan-Killiany atlas regions (34 regions per hemisphere + left and right hemisphere mean thickness), and performed partial correlation analyses with total schizotypy scores in R to predict left, right and mean cortical thickness by region, adjusting by sex and age. Random-effects meta-analyses of partial correlation effect sizes for each region were performed using R{\textquoteright}s metafor package. Results Schizotypy scores were positively associated with mean cortical thickness of the medial orbitofrontal cortex (r=0.077; pFDR=0.006) and the frontal pole (r=0.073; pFDR=0.006). By hemisphere, schizotypy was associated with cortical thickness of the left medial orbitofrontal cortex (r=0.066; pFDR=0.044), and at trend-level with the right medial orbitofrontal cortex and left frontal pole (both r=0.062; pFDR=0.053). Conclusions Worldwide cooperative analyses of neuroimaging data shows that subclinical psychotic-like experiences are associated with greater prefrontal cortical thickness. The directionality of the effects is opposite to that of thinner cortex in schizophrenia. Given that accelerated prefrontal thinning has been associated with progression to psychosis in at-risk individuals, our findings may reflect mechanisms of resilience in schizotypy. Supported By GM is supported by a Sir Henry Dale Fellowship, jointly funded by The Wellcome Trust and The Royal Society. Keywords Schizotypy, Psychosis, Structural MRI, ENIGMA Consortium, Neuroanatomy",

author = "M. Antoniades and I. Nenadic and T. Kircher and A. Krug and A. Fornito and U. Dannlowski and P. DeRosse and B. Baune and M. Green and Y. Quid{\'e} and C. Pantelis and R. Chan and U. Ettinger and M. Debban{\'e} and C. Gaser and B. Besteher and K. Diederen and T. Spencer and W. R{\"o}ssler and V. Kumari and H. Park and I. Lemmers-Jansen and P. Allen and J.B. Marsman and J. Gilleen and M. Kirschner and A. Dagher and I. Lebedeva and S. Kaiser and A. Fett and I. Sommer and \{van Erp\}, T. and J. Turner and P.M. Thompson and A. Aleman and \{Modinos for the ENIGMA Schizotypy Working Group\}, G.",

year = "2020",

doi = "10.1016/j.biopsych.2020.02.807",

language = "English",

volume = "87",

pages = "S313--S314",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "9",

}

Antoniades, M, Nenadic, I, Kircher, T, Krug, A, Fornito, A, Dannlowski, U, DeRosse, P, Baune, B, Green, M, Quidé, Y, Pantelis, C, Chan, R, Ettinger, U, Debbané, M, Gaser, C, Besteher, B, Diederen, K, Spencer, T, Rössler, W, Kumari, V, Park, H, Lemmers-Jansen, I, Allen, P, Marsman, JB, Gilleen, J, Kirschner, M, Dagher, A, Lebedeva, I, Kaiser, S, Fett, A, Sommer, I, van Erp, T, Turner, J, Thompson, PM, Aleman, A & Modinos for the ENIGMA Schizotypy Working Group, G 2020, 'Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.', Biological Psychiatry, vol. 87, no. 9, pp. S313-S314. https://doi.org/10.1016/j.biopsych.2020.02.807

TY - JOUR

T1 - Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.

AU - Antoniades, M.

AU - Nenadic, I.

AU - Kircher, T.

AU - Krug, A.

AU - Fornito, A.

AU - Dannlowski, U.

AU - DeRosse, P.

AU - Baune, B.

AU - Green, M.

AU - Quidé, Y.

AU - Pantelis, C.

AU - Chan, R.

AU - Ettinger, U.

AU - Debbané, M.

AU - Gaser, C.

AU - Besteher, B.

AU - Diederen, K.

AU - Spencer, T.

AU - Rössler, W.

AU - Kumari, V.

AU - Park, H.

AU - Lemmers-Jansen, I.

AU - Allen, P.

AU - Marsman, J.B.

AU - Gilleen, J.

AU - Kirschner, M.

AU - Dagher, A.

AU - Lebedeva, I.

AU - Kaiser, S.

AU - Fett, A.

AU - Sommer, I.

AU - van Erp, T.

AU - Turner, J.

AU - Thompson, P.M.

AU - Aleman, A.

AU - Modinos for the ENIGMA Schizotypy Working Group, G.

PY - 2020

Y1 - 2020

N2 - Recent meta-analytical evidence indicates that cortical thickness abnormalities in schizophrenia are influenced by illness severity and antipsychotic medication exposure. Schizotypy research allows investigating the neuroanatomical correlates of psychotic-like experiences without illness- and treatment-related confounders. Here we present the first large-scale meta-analysis of cortical thickness in schizotypy across 23 datasets worldwide. Methods The study involved structural MRI scans from 2,695 healthy individuals (mean [range] age, 29.1 [17-55.8], 46.3% male) who also completed self-report schizotypy questionnaires. Each site used FreeSurfer to extract cortical thickness for 70 Desikan-Killiany atlas regions (34 regions per hemisphere + left and right hemisphere mean thickness), and performed partial correlation analyses with total schizotypy scores in R to predict left, right and mean cortical thickness by region, adjusting by sex and age. Random-effects meta-analyses of partial correlation effect sizes for each region were performed using R’s metafor package. Results Schizotypy scores were positively associated with mean cortical thickness of the medial orbitofrontal cortex (r=0.077; pFDR=0.006) and the frontal pole (r=0.073; pFDR=0.006). By hemisphere, schizotypy was associated with cortical thickness of the left medial orbitofrontal cortex (r=0.066; pFDR=0.044), and at trend-level with the right medial orbitofrontal cortex and left frontal pole (both r=0.062; pFDR=0.053). Conclusions Worldwide cooperative analyses of neuroimaging data shows that subclinical psychotic-like experiences are associated with greater prefrontal cortical thickness. The directionality of the effects is opposite to that of thinner cortex in schizophrenia. Given that accelerated prefrontal thinning has been associated with progression to psychosis in at-risk individuals, our findings may reflect mechanisms of resilience in schizotypy. Supported By GM is supported by a Sir Henry Dale Fellowship, jointly funded by The Wellcome Trust and The Royal Society. Keywords Schizotypy, Psychosis, Structural MRI, ENIGMA Consortium, Neuroanatomy

AB - Recent meta-analytical evidence indicates that cortical thickness abnormalities in schizophrenia are influenced by illness severity and antipsychotic medication exposure. Schizotypy research allows investigating the neuroanatomical correlates of psychotic-like experiences without illness- and treatment-related confounders. Here we present the first large-scale meta-analysis of cortical thickness in schizotypy across 23 datasets worldwide. Methods The study involved structural MRI scans from 2,695 healthy individuals (mean [range] age, 29.1 [17-55.8], 46.3% male) who also completed self-report schizotypy questionnaires. Each site used FreeSurfer to extract cortical thickness for 70 Desikan-Killiany atlas regions (34 regions per hemisphere + left and right hemisphere mean thickness), and performed partial correlation analyses with total schizotypy scores in R to predict left, right and mean cortical thickness by region, adjusting by sex and age. Random-effects meta-analyses of partial correlation effect sizes for each region were performed using R’s metafor package. Results Schizotypy scores were positively associated with mean cortical thickness of the medial orbitofrontal cortex (r=0.077; pFDR=0.006) and the frontal pole (r=0.073; pFDR=0.006). By hemisphere, schizotypy was associated with cortical thickness of the left medial orbitofrontal cortex (r=0.066; pFDR=0.044), and at trend-level with the right medial orbitofrontal cortex and left frontal pole (both r=0.062; pFDR=0.053). Conclusions Worldwide cooperative analyses of neuroimaging data shows that subclinical psychotic-like experiences are associated with greater prefrontal cortical thickness. The directionality of the effects is opposite to that of thinner cortex in schizophrenia. Given that accelerated prefrontal thinning has been associated with progression to psychosis in at-risk individuals, our findings may reflect mechanisms of resilience in schizotypy. Supported By GM is supported by a Sir Henry Dale Fellowship, jointly funded by The Wellcome Trust and The Royal Society. Keywords Schizotypy, Psychosis, Structural MRI, ENIGMA Consortium, Neuroanatomy

U2 - 10.1016/j.biopsych.2020.02.807

DO - 10.1016/j.biopsych.2020.02.807

M3 - Article

SN - 0006-3223

VL - 87

SP - S313-S314

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 9

ER -

Neuroanatomical Correlates of Psychotic-Like Experiences Assessed in 2,695 Individuals via the ENIGMA Consortium.

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