Neurobeachin regulates neurotransmitter receptor trafficking to synapses

R. Nair; J. Lauks; S Jung; N.E. Cooke; H. de Wit; N. Brose; M.W. Kilimann; M. Verhage; J. Rhee

doi:10.1083/jcb.201207113

Neurobeachin regulates neurotransmitter receptor trafficking to synapses

R. Nair, J. Lauks, S Jung, N.E. Cooke, H. de Wit, N. Brose, M.W. Kilimann, M. Verhage, J. Rhee

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had strongly reduced synaptic responses caused by a reduction in surface levels of glutamate and GABA

Original language	English
Pages (from-to)	61-80
Journal	Journal of Cell Biology
Volume	200
Issue number	1
DOIs	https://doi.org/10.1083/jcb.201207113
Publication status	Published - 2013

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10.1083/jcb.201207113

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abstract = "The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had strongly reduced synaptic responses caused by a reduction in surface levels of glutamate and GABA",

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AU - Lauks, J.

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AU - Brose, N.

AU - Kilimann, M.W.

AU - Verhage, M.

AU - Rhee, J.

PY - 2013

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AB - The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had strongly reduced synaptic responses caused by a reduction in surface levels of glutamate and GABA

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Neurobeachin regulates neurotransmitter receptor trafficking to synapses

Abstract

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