Neurobeachin regulates neurotransmitter receptor trafficking to synapses

R. Nair, J. Lauks, S Jung, N.E. Cooke, H. de Wit, N. Brose, M.W. Kilimann, M. Verhage, J. Rhee

Research output: Contribution to JournalArticleAcademicpeer-review


The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had strongly reduced synaptic responses caused by a reduction in surface levels of glutamate and GABA
Original languageEnglish
Pages (from-to)61-80
JournalJournal of Cell Biology
Issue number1
Publication statusPublished - 2013


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