Neuromuscular control during gait in people with haemophilic arthropathy

Carlos Cruz-Montecinos, Sofía Pérez-Alenda, Mauricio Cerda, Huub Maas

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Introduction: Effects of haemophilic arthropathy on neuromuscular control during gait are currently unknown. Aims: (a) To assess how haemophilic arthropathy affects the complexity of neuromuscular control during gait; (b) To investigate the relationship between complexity of neuromuscular control and joint impairment. Methods: Thirteen control subjects (CG) walked overground at their preferred and a slow velocity and thirteen people with haemophilic arthropathy (PWHA) walking at their preferred velocity. Surface electromyography (EMG) was collected from eleven leg muscles. Electromyography variance explained by muscle synergies (sets of co-activated muscles that can be recruited by a single signal) was calculated by the total variance accounted (tVAF). Three measures were used to evaluate complexity of neuromuscular control: (a) the number of synergies required for tVAF > 90%, (b) tVAF as a function of the number of muscle synergies, and (c) the dynamic motor control index (Walk-DMC). Impairment of ankle and knee joints was determined by the Haemophilia Joint Health Score (HJHS). Results: The same number of the muscle synergies was found for each group (P > 0.05). For both walking velocities tested, tVAF1 was higher in PHWA (P < 0.05). The Walk-DMC of PWHA was lower than that of the CG for both walking velocities (P < 0.05). For PWHA, no significant correlation was found between HJHS (sum knee and ankle) and Walk-DMC index (r = −0.32, P = 0.28). Conclusions: These results indicate differences between PWHA and CG in the neuromuscular control of gait. The Walk-DMC and tVAF1 may be useful measures to assess changes in neuromuscular control in response to treatment.

Original languageEnglish
Pages (from-to)e69-e77
JournalHaemophilia
Volume25
Issue number2
Early online date1 Feb 2019
DOIs
Publication statusPublished - Mar 2019

Fingerprint

Joint Diseases
Gait
Muscles
Walking
Joints
Hemophilia A
Electromyography
Ankle Joint
Health
Knee Joint
Ankle
Leg
Knee

Keywords

  • ankle joint
  • haemophilia
  • knee joint
  • muscle synergy
  • neuromuscular control
  • surface electromyography

Cite this

Cruz-Montecinos, Carlos ; Pérez-Alenda, Sofía ; Cerda, Mauricio ; Maas, Huub. / Neuromuscular control during gait in people with haemophilic arthropathy. In: Haemophilia. 2019 ; Vol. 25, No. 2. pp. e69-e77.
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abstract = "Introduction: Effects of haemophilic arthropathy on neuromuscular control during gait are currently unknown. Aims: (a) To assess how haemophilic arthropathy affects the complexity of neuromuscular control during gait; (b) To investigate the relationship between complexity of neuromuscular control and joint impairment. Methods: Thirteen control subjects (CG) walked overground at their preferred and a slow velocity and thirteen people with haemophilic arthropathy (PWHA) walking at their preferred velocity. Surface electromyography (EMG) was collected from eleven leg muscles. Electromyography variance explained by muscle synergies (sets of co-activated muscles that can be recruited by a single signal) was calculated by the total variance accounted (tVAF). Three measures were used to evaluate complexity of neuromuscular control: (a) the number of synergies required for tVAF > 90{\%}, (b) tVAF as a function of the number of muscle synergies, and (c) the dynamic motor control index (Walk-DMC). Impairment of ankle and knee joints was determined by the Haemophilia Joint Health Score (HJHS). Results: The same number of the muscle synergies was found for each group (P > 0.05). For both walking velocities tested, tVAF1 was higher in PHWA (P < 0.05). The Walk-DMC of PWHA was lower than that of the CG for both walking velocities (P < 0.05). For PWHA, no significant correlation was found between HJHS (sum knee and ankle) and Walk-DMC index (r = −0.32, P = 0.28). Conclusions: These results indicate differences between PWHA and CG in the neuromuscular control of gait. The Walk-DMC and tVAF1 may be useful measures to assess changes in neuromuscular control in response to treatment.",
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Cruz-Montecinos, C, Pérez-Alenda, S, Cerda, M & Maas, H 2019, 'Neuromuscular control during gait in people with haemophilic arthropathy' Haemophilia, vol. 25, no. 2, pp. e69-e77. https://doi.org/10.1111/hae.13697

Neuromuscular control during gait in people with haemophilic arthropathy. / Cruz-Montecinos, Carlos; Pérez-Alenda, Sofía; Cerda, Mauricio; Maas, Huub.

In: Haemophilia, Vol. 25, No. 2, 03.2019, p. e69-e77.

Research output: Contribution to JournalArticleAcademicpeer-review

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AB - Introduction: Effects of haemophilic arthropathy on neuromuscular control during gait are currently unknown. Aims: (a) To assess how haemophilic arthropathy affects the complexity of neuromuscular control during gait; (b) To investigate the relationship between complexity of neuromuscular control and joint impairment. Methods: Thirteen control subjects (CG) walked overground at their preferred and a slow velocity and thirteen people with haemophilic arthropathy (PWHA) walking at their preferred velocity. Surface electromyography (EMG) was collected from eleven leg muscles. Electromyography variance explained by muscle synergies (sets of co-activated muscles that can be recruited by a single signal) was calculated by the total variance accounted (tVAF). Three measures were used to evaluate complexity of neuromuscular control: (a) the number of synergies required for tVAF > 90%, (b) tVAF as a function of the number of muscle synergies, and (c) the dynamic motor control index (Walk-DMC). Impairment of ankle and knee joints was determined by the Haemophilia Joint Health Score (HJHS). Results: The same number of the muscle synergies was found for each group (P > 0.05). For both walking velocities tested, tVAF1 was higher in PHWA (P < 0.05). The Walk-DMC of PWHA was lower than that of the CG for both walking velocities (P < 0.05). For PWHA, no significant correlation was found between HJHS (sum knee and ankle) and Walk-DMC index (r = −0.32, P = 0.28). Conclusions: These results indicate differences between PWHA and CG in the neuromuscular control of gait. The Walk-DMC and tVAF1 may be useful measures to assess changes in neuromuscular control in response to treatment.

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KW - surface electromyography

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