Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function

C. Blanchetot; D. Verzijl; A. Mujic-Delic; L. Bosch; L. Rem; R. Leurs; C.T. Verrips; M. Saunders; H. Haard de; M.J. Smit

doi:10.1074/jbc.M113.467969

Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function

C. Blanchetot, D. Verzijl, A. Mujic-Delic, L. Bosch, L. Rem, R. Leurs, C.T. Verrips, M. Saunders, H. Haard de, M.J. Smit

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Chemokines play a prominent role in inflammatory diseases. Results: Nanobodies targeting chemokines display high affinity and potently neutralize chemokine-induced receptor binding and signaling. Conclusion: Neutralizing Nanobodies targeting chemokines effectively inhibit chemokine function. Significance: Nanobodies directed against inflammatory and homeostatic chemokines form a promising new class of potent and specific inhibitors of chemokine function, to be used for research and therapeutic purposes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Original language	English
Pages (from-to)	25173-25182
Journal	Journal of Biological Chemistry
Volume	2013
Issue number	288
DOIs	https://doi.org/10.1074/jbc.M113.467969
Publication status	Published - 2013

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10.1074/jbc.M113.467969

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title = "Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function",

abstract = "Background: Chemokines play a prominent role in inflammatory diseases. Results: Nanobodies targeting chemokines display high affinity and potently neutralize chemokine-induced receptor binding and signaling. Conclusion: Neutralizing Nanobodies targeting chemokines effectively inhibit chemokine function. Significance: Nanobodies directed against inflammatory and homeostatic chemokines form a promising new class of potent and specific inhibitors of chemokine function, to be used for research and therapeutic purposes. {\textcopyright} 2013 by The American Society for Biochemistry and Molecular Biology, Inc.",

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T1 - Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function

AU - Blanchetot, C.

AU - Verzijl, D.

AU - Mujic-Delic, A.

AU - Bosch, L.

AU - Rem, L.

AU - Leurs, R.

AU - Verrips, C.T.

AU - Saunders, M.

AU - Haard de, H.

AU - Smit, M.J.

PY - 2013

Y1 - 2013

N2 - Background: Chemokines play a prominent role in inflammatory diseases. Results: Nanobodies targeting chemokines display high affinity and potently neutralize chemokine-induced receptor binding and signaling. Conclusion: Neutralizing Nanobodies targeting chemokines effectively inhibit chemokine function. Significance: Nanobodies directed against inflammatory and homeostatic chemokines form a promising new class of potent and specific inhibitors of chemokine function, to be used for research and therapeutic purposes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

AB - Background: Chemokines play a prominent role in inflammatory diseases. Results: Nanobodies targeting chemokines display high affinity and potently neutralize chemokine-induced receptor binding and signaling. Conclusion: Neutralizing Nanobodies targeting chemokines effectively inhibit chemokine function. Significance: Nanobodies directed against inflammatory and homeostatic chemokines form a promising new class of potent and specific inhibitors of chemokine function, to be used for research and therapeutic purposes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

U2 - 10.1074/jbc.M113.467969

DO - 10.1074/jbc.M113.467969

M3 - Article

SN - 0021-9258

VL - 2013

SP - 25173

EP - 25182

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 288

ER -

Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function

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