Abstract
Background: Chemokines play a prominent role in inflammatory diseases. Results: Nanobodies targeting chemokines display high affinity and potently neutralize chemokine-induced receptor binding and signaling. Conclusion: Neutralizing Nanobodies targeting chemokines effectively inhibit chemokine function. Significance: Nanobodies directed against inflammatory and homeostatic chemokines form a promising new class of potent and specific inhibitors of chemokine function, to be used for research and therapeutic purposes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 25173-25182 |
| Journal | Journal of Biological Chemistry |
| Volume | 2013 |
| Issue number | 288 |
| DOIs | |
| Publication status | Published - 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'Neutralizing Nanobodies targeting diverse chemokines effectively inhibit chemokine function'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver