New advances in CMV and immunosenescence

Paolo Sansoni, Rosanna Vescovini, Francesco F Fagnoni, Arne Akbar, Ramon Arens, Yen-Ling Chiu, Luka Cičin-Šain, Julie Dechanet-Merville, Evelyna Derhovanessian, Sara Ferrando-Martinez, Claudio Franceschi, Daniela Frasca, Tamas Fulöp, David Furman, Effrossyni Gkrania-Klotsas, Felicia Goodrum, Beatrix Grubeck-Loebenstein, Mikko Hurme, Florian Kern, Daniele Lilleri & 20 others Miguel López-Botet, Andrea B Maier, Thomas Marandu, Arnaud Marchant, Catharina Matheï, Paul Moss, Aura Muntasell, Ester B M Remmerswaal, Natalie E Riddell, Kathrin Rothe, Delphine Sauce, Eui-Cheol Shin, Amanda M Simanek, Megan J Smithey, Cecilia Söderberg-Nauclér, Rafael Solana, Paul G Thomas, Rene van Lier, Graham Pawelec, Janko Nikolich-Zugich

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Original languageEnglish
Pages (from-to)54-62
Number of pages9
JournalExperimental Gerontology
Volume55
DOIs
Publication statusPublished - Jul 2014

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Immune system
Cytomegalovirus
Aging of materials
Cytomegalovirus Infections
Immune System
Vaccines
Italy
Epidemiologic Studies
Immunity
Education
Immunosenescence

Bibliographical note

Copyright © 2014. Published by Elsevier Inc.

Keywords

  • Aging/immunology
  • Cytomegalovirus/immunology
  • Cytomegalovirus Infections/immunology
  • Host-Pathogen Interactions/immunology
  • Humans
  • Virus Latency/immunology

Cite this

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y-L., ... Nikolich-Zugich, J. (2014). New advances in CMV and immunosenescence. Experimental Gerontology, 55, 54-62. https://doi.org/10.1016/j.exger.2014.03.020
Sansoni, Paolo ; Vescovini, Rosanna ; Fagnoni, Francesco F ; Akbar, Arne ; Arens, Ramon ; Chiu, Yen-Ling ; Cičin-Šain, Luka ; Dechanet-Merville, Julie ; Derhovanessian, Evelyna ; Ferrando-Martinez, Sara ; Franceschi, Claudio ; Frasca, Daniela ; Fulöp, Tamas ; Furman, David ; Gkrania-Klotsas, Effrossyni ; Goodrum, Felicia ; Grubeck-Loebenstein, Beatrix ; Hurme, Mikko ; Kern, Florian ; Lilleri, Daniele ; López-Botet, Miguel ; Maier, Andrea B ; Marandu, Thomas ; Marchant, Arnaud ; Matheï, Catharina ; Moss, Paul ; Muntasell, Aura ; Remmerswaal, Ester B M ; Riddell, Natalie E ; Rothe, Kathrin ; Sauce, Delphine ; Shin, Eui-Cheol ; Simanek, Amanda M ; Smithey, Megan J ; Söderberg-Nauclér, Cecilia ; Solana, Rafael ; Thomas, Paul G ; van Lier, Rene ; Pawelec, Graham ; Nikolich-Zugich, Janko. / New advances in CMV and immunosenescence. In: Experimental Gerontology. 2014 ; Vol. 55. pp. 54-62.
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abstract = "Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on {"}CMV & Immunosenescence{"}, held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.",
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Sansoni, P, Vescovini, R, Fagnoni, FF, Akbar, A, Arens, R, Chiu, Y-L, Cičin-Šain, L, Dechanet-Merville, J, Derhovanessian, E, Ferrando-Martinez, S, Franceschi, C, Frasca, D, Fulöp, T, Furman, D, Gkrania-Klotsas, E, Goodrum, F, Grubeck-Loebenstein, B, Hurme, M, Kern, F, Lilleri, D, López-Botet, M, Maier, AB, Marandu, T, Marchant, A, Matheï, C, Moss, P, Muntasell, A, Remmerswaal, EBM, Riddell, NE, Rothe, K, Sauce, D, Shin, E-C, Simanek, AM, Smithey, MJ, Söderberg-Nauclér, C, Solana, R, Thomas, PG, van Lier, R, Pawelec, G & Nikolich-Zugich, J 2014, 'New advances in CMV and immunosenescence' Experimental Gerontology, vol. 55, pp. 54-62. https://doi.org/10.1016/j.exger.2014.03.020

New advances in CMV and immunosenescence. / Sansoni, Paolo; Vescovini, Rosanna; Fagnoni, Francesco F; Akbar, Arne; Arens, Ramon; Chiu, Yen-Ling; Cičin-Šain, Luka; Dechanet-Merville, Julie; Derhovanessian, Evelyna; Ferrando-Martinez, Sara; Franceschi, Claudio; Frasca, Daniela; Fulöp, Tamas; Furman, David; Gkrania-Klotsas, Effrossyni; Goodrum, Felicia; Grubeck-Loebenstein, Beatrix; Hurme, Mikko; Kern, Florian; Lilleri, Daniele; López-Botet, Miguel; Maier, Andrea B; Marandu, Thomas; Marchant, Arnaud; Matheï, Catharina; Moss, Paul; Muntasell, Aura; Remmerswaal, Ester B M; Riddell, Natalie E; Rothe, Kathrin; Sauce, Delphine; Shin, Eui-Cheol; Simanek, Amanda M; Smithey, Megan J; Söderberg-Nauclér, Cecilia; Solana, Rafael; Thomas, Paul G; van Lier, Rene; Pawelec, Graham; Nikolich-Zugich, Janko.

In: Experimental Gerontology, Vol. 55, 07.2014, p. 54-62.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - New advances in CMV and immunosenescence

AU - Sansoni, Paolo

AU - Vescovini, Rosanna

AU - Fagnoni, Francesco F

AU - Akbar, Arne

AU - Arens, Ramon

AU - Chiu, Yen-Ling

AU - Cičin-Šain, Luka

AU - Dechanet-Merville, Julie

AU - Derhovanessian, Evelyna

AU - Ferrando-Martinez, Sara

AU - Franceschi, Claudio

AU - Frasca, Daniela

AU - Fulöp, Tamas

AU - Furman, David

AU - Gkrania-Klotsas, Effrossyni

AU - Goodrum, Felicia

AU - Grubeck-Loebenstein, Beatrix

AU - Hurme, Mikko

AU - Kern, Florian

AU - Lilleri, Daniele

AU - López-Botet, Miguel

AU - Maier, Andrea B

AU - Marandu, Thomas

AU - Marchant, Arnaud

AU - Matheï, Catharina

AU - Moss, Paul

AU - Muntasell, Aura

AU - Remmerswaal, Ester B M

AU - Riddell, Natalie E

AU - Rothe, Kathrin

AU - Sauce, Delphine

AU - Shin, Eui-Cheol

AU - Simanek, Amanda M

AU - Smithey, Megan J

AU - Söderberg-Nauclér, Cecilia

AU - Solana, Rafael

AU - Thomas, Paul G

AU - van Lier, Rene

AU - Pawelec, Graham

AU - Nikolich-Zugich, Janko

N1 - Copyright © 2014. Published by Elsevier Inc.

PY - 2014/7

Y1 - 2014/7

N2 - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

AB - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

KW - Aging/immunology

KW - Cytomegalovirus/immunology

KW - Cytomegalovirus Infections/immunology

KW - Host-Pathogen Interactions/immunology

KW - Humans

KW - Virus Latency/immunology

U2 - 10.1016/j.exger.2014.03.020

DO - 10.1016/j.exger.2014.03.020

M3 - Article

VL - 55

SP - 54

EP - 62

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu Y-L et al. New advances in CMV and immunosenescence. Experimental Gerontology. 2014 Jul;55:54-62. https://doi.org/10.1016/j.exger.2014.03.020