New genetic loci link adipose and insulin biology to body fat distribution

D. Shungin, T.W. Winkler, D.C. Croteau-Chonka, T. Ferreira, A.E. Lockes, R. Maegi, R.J. Strawbridge, T.H. Pers, K. Fischer, A.E. Justice, T. Workalemahu, J.M.W. Wu, M.L. Buchkovich, N.L. Heard-Costa, T.S. Roman, A.W. Drong, C. Song, S. Gustafsson, F.R. Day, T. EskoT. Fall, Z. Kutalik, J. Luan, J.C. Randall, A. Scherag, S. Vedantam, A.R. Wood, J. Chen, R. Fehrmann, J. Karjalainen, B. Kahali, C. Liu, E.M. Schmidt, D. Absher, N. Amin, D. Anderson, M. Beekman, J.L. Bragg-Gresham, S. Buyske, A. Demirkan, G.B. Ehret, M.F. Feitosa, A. Goel, A.U. Jackson, T. Johnson, M.E. Kleber, K. Kristiansson, M. Mangino, I.M. Leach, C. Medina-Gomez, C.D. Palmer, D. Pasko, S. Pechlivaniss, MJ Peters, I. Prokopenko, A. Stancakova, Y.J. Sung, T. Tanakam, A. Teumer, J.V. van Vliet-Ostaptchouk, L. Yengo, W. Zhang, E. Albrecht, J. Arnlov, G.M. Arscott, S. Bandinelli, A. Barrett, C. Bellis, A.J. Bennett, C. Berne, M. Blueher, S. Buhringer, F. Bonnet, Y. Boettcher, M. Bruinenberg, D.B. Carba, I.H. Caspersen, R. Clarke, E.W. Daw, J. Deelen, E Deelman, G. Delgado, A.S.F. Doney, N. Eklund, M.R. Erdos, K. Estrada, E. Eury, N. Friedrichs, M.E. Garcia, V. Giedraitis, B. Gigante, A.S. Go, A. Golay, H. Grallert, T.B. Grammer, J. Graessler, J. Grewal, C.J. Groves, T. Haller, G. Hallmans, C.A. Hartman, M. Hassinen, C. Hayward, K. Heikkila, K. Herzig, Q. Helmer, H.L. Hillege, O. Holmen, S.C. Hunt, A. Isaacs, T. Ittermann, A.L. James, I. Johansson, T. Juliusdottir, I. Kalafati, L. Kinnunen, W. Koenig, I.K. Kooner, W. Kratzer, C. Lamina, K. Leander, N.R. Lee, P. Lichtner, L. Lind, J. Lindstrom, S. Lobbens, M. Lorentzon, F. Mach, P.K.E. Magnusson, A. Mahajan, W.L. McArdle, C. Menni, S. Merger, E. Mihailov, L. Milani, R. Mills, A. Moayyeri, K.L. Monda, S.P. Mooijaart, T.W. Muehleisen, A. Mulas, G. Mueller, M. Mueller-Nurasyid, R. Nagaraja, M.A. Nalls, N. Narisu, N. Glorioso, I.M. Nolte, M. Olden, N.W. Rayner, F. Renstrom, J.S. Ried, N.R. Robertson, L.M. Rose, S. Sanna, H. Scharnagl, S. Scholtens, B. Sennblad, T. Seufferlein, C.M. Sitlani, A.V. Smith, K. Stirrups, H.M. Stringham, J. Sundstrom, M.A. Swertz, A.J. Swift, A. Syvanen, B.O. Tayo, B. Thorand, G. Thorleifsson, A. Tomaschitz, C. Troffa, F.V.A. van Oort, N. Verweij, J.M. Vonk, L.L. Waite, R. Wennauer, T. Wilsgaard, M.K. Wojczynski, A. Wong, Q. Zhang, J.H. Zhao, E.P. Brennan, M. Choi, P. Eriksson, L. Folkersen, A. Franco-Cereceda, A.G. Gharavi, A.K. Hedman, M. Hivert, J. Huang, S. Kanoni, F. Karpe, S. Keildson, K. Kiryluk, L. Liang, R.P. Lifton, B. Ma, A.J. McKnight, R. McPherson, A. Metspalu, J.L. Min, M.F. Moffatt, G.W. Montgomery, J.M. Murabito, G. Nicholson, DR Nyholt, C. Olsson, J.R.B. Perry, E. Reinmaa, R.M. Salem, N. Sandholm, E.E. Schadt, R.A. Scott, L. Stolk, E.E. Vallejo, H. Westra, K.T. Zondervan, P. Amouyel, D. Arveiler, S.J.L. Bakker, J. Beilby, R.N. Bergman, J. Blangero, M.J. Brown, M. Burnier, H. Campbell, A. Chakravarti, P.S. Chiness, S. Claudi-Boehmi, F.S. Collins, D.C. Crawford, J. Danesh, U. de Faire, E.J.C. de Geus, M Doerr, R. Erbel, J.G. Eriksson, M. Farrall, E. Ferrannini, J. Ferrieres, N.G. Forouhi, T. Forrester, O.H. Franco, R.T. Gansevoort, C. Gieger, V. Gudnason, C.A. Haiman, T.B. Harris, A.T. Hattersley, M. Heliovaara, A.A. Hicks, A.D. Hingorani, W. Hoffmann, A. Hofman, G. Homuth, S.E. Humphries, E. Hyppoenen, T. Illig, M. Jarvelin, B. Johansen, P. Jousilahti, A.M. Jula, J. Kaprio, F Kee, S.M. Keinanen-Kiukaanniemi, J.S. Kooner, C. Kooperberg, P. Kovacs, A.T. Kraja, M. Kumari, K. Kuulasmaa, J. Kuusisto, T.A. Lakka, C. Langenberg, L. Le Marchand, T. Lehtimaki, V. Lyssenko, S. Mannisto, A. Marette, T.C. Matise, C.A. McKenzie, B. McKnight, A.W. Musk, S. Mohlenkamp, A.D. Morris, M. Nelis, C. Ohlsson, A.J. Oldehinkel, K.K. Ong, L.J. Palmer, B.W.J.H. Penninx, A. Peters, P.P. Pramstaller, O.T. Raitakari, T. Rankinen, D.C. Rao, T.K. Rice, P.M. Ridker, M.D. Ritchie, I. Rudan, V. Salomaa, N.J. Samani, J. Saramies, M.A. Sarzynski, P.E.H. Schwarz, A.R. Shuldiner, J.A. Staessen, V. Steinthorsdottir, R.P Stolk, K. Strauch, A. Toenjes, A. Tremblay, E. Tremoli, M. Vohl, U. Voelker, P. Vollenweider, J.F. Wilson, J.C. Witteman, L.S. Adair, M. Bochud, B.O. Boehm, S.R. Bornstein, C. Bouchard, S. Cauchi, M.J. Caulfield, J.C. Chambers, D.I. Chasman, R.S. Cooper, G. Dedoussis, L. Ferrucci, P. Froguel, H. Grabe, A. Hamsten, J. Hui, K. Hveem, K. Joeckel, M. Kivimaki, D Kuh, M. Laakso, Y. Liu, W. Maerz, P.B. Munroe, I. Njolstad, B.A. Oostra, C.N.A. Palmer, N.L. Pedersen, M. Perola, L. Perusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T.E. Saaristo, D. Saleheen, J. Sinisalo, P.E. Slagboom, H. Snieder, T.D. Spector, U.R. Thorsteinsdottir, M. Stumvoll, J. Tuomilehto, A. G. Uitterlinden, M. Uusitupa, P. van der Harst, G. Veronesi, M. Walker, N.J. Wareham, H. Watkins, H. Wichmann, G.R. Abecasis, T.L. Assimes, S.I. Berndt, M. Boehnkes, I.B. Borecki, P. Deloukas, L. Franke, T.M. Frayling, L.C. Groop, D.J. Hunter, R.C. Kaplan, J.R. O'Connell, L. Qi, D. Schlessinger, D.P. Strachan, K. Stefansson, C.M. van Dujin, C.J. Willer, P. M. Visscher, J. Yang, J.N. Hirschhorn, M.C. Zillikens, M.I. McCarthy, E.K. Speliotes, K.E. North, C.S. Fox, I. Barroso, P.W. Franks, E. Ingelsson, I.M. Heid, R.J.F. Loos, L.A. Cupples, A.P. Morris, C.M. Lindgren, K.L. Mohlke

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10
Original languageEnglish
Pages (from-to)187-196
JournalNature
Volume518
Issue number7538
DOIs
Publication statusPublished - 2015

Bibliographical note

PT: J; UT: WOS:000349190300030

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    Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Lockes, A. E., Maegi, R., ... Mohlke, K. L. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. https://doi.org/10.1038/nature14132