New Insights into the Reactivity of Cisplatin with Free and Restrained Nucleophiles: Microsolvation Effects and Base Selectivity in Cisplatin-DNA Interactions

Abel de Cozar; Olatz Larranaga; F. Matthias Bickelhaupt; Eider San Sebastian; Elisabeth Ortega-Carrasco; Jean-Didier Marechal; Agusti Lledos; Fernando P. Cossio

doi:10.1002/cphc.201600982

New Insights into the Reactivity of Cisplatin with Free and Restrained Nucleophiles: Microsolvation Effects and Base Selectivity in Cisplatin-DNA Interactions

Abel de Cozar, Olatz Larranaga, F. Matthias Bickelhaupt, Eider San Sebastian, Elisabeth Ortega-Carrasco, Jean-Didier Marechal, Agusti Lledos, Fernando P. Cossio

Research output: Contribution to Journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	3932-3947
Journal	ChemPhysChem
Volume	17
Issue number	23
DOIs	https://doi.org/10.1002/cphc.201600982
Publication status	Published - Dec 2016

Keywords

activation-strain model
cisplatin
density functional calculations
kinetics
nucleophiles

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10.1002/cphc.201600982

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de Cozar, A., Larranaga, O., Bickelhaupt, F. M., Sebastian, E. S., Ortega-Carrasco, E., Marechal, J.-D., Lledos, A., & Cossio, F. P. (2016). New Insights into the Reactivity of Cisplatin with Free and Restrained Nucleophiles: Microsolvation Effects and Base Selectivity in Cisplatin-DNA Interactions. ChemPhysChem, 17(23), 3932-3947. https://doi.org/10.1002/cphc.201600982

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keywords = "activation-strain model, cisplatin, density functional calculations, kinetics, nucleophiles",

author = "{de Cozar}, Abel and Olatz Larranaga and Bickelhaupt, {F. Matthias} and Sebastian, {Eider San} and Elisabeth Ortega-Carrasco and Jean-Didier Marechal and Agusti Lledos and Cossio, {Fernando P.}",

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AU - Larranaga, Olatz

AU - Bickelhaupt, F. Matthias

AU - Sebastian, Eider San

AU - Ortega-Carrasco, Elisabeth

AU - Marechal, Jean-Didier

AU - Lledos, Agusti

AU - Cossio, Fernando P.

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KW - cisplatin

KW - density functional calculations

KW - kinetics

KW - nucleophiles

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JO - ChemPhysChem

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