Abstract
The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands. © 2013 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 12-22 |
Journal | Trends in Pharmacological Sciences |
Volume | 35 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
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Dive into the research topics of 'New insights into the structure of Class B G protein-coupled receptors'. Together they form a unique fingerprint.Datasets
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Secretin-like class B G protein-coupled receptor (GPCR) mutation data set
de Graaf, C. (Contributor), Unknown Publisher, 1 Jan 2014
DOI: 10.5281/zenodo.60790, https://zenodo.org/record/60790
Dataset / Software: Dataset