New insights into the structure of Class B G protein-coupled receptors

H. Hollenstein, C. de Graaf, A. Bortolato, M-W Wang, F. Marshall, R.C. Stevens

Research output: Contribution to JournalArticleAcademicpeer-review


The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands. © 2013 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)12-22
JournalTrends in Pharmacological Sciences
Issue number1
Publication statusPublished - 2014


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