New insights into the structure of Class B G protein-coupled receptors

H. Hollenstein; C. de Graaf; A. Bortolato; M-W Wang; F. Marshall; R.C. Stevens

doi:10.1016/j.tips.2013.11.001

New insights into the structure of Class B G protein-coupled receptors

H. Hollenstein
, C. de Graaf
, A. Bortolato
, M-W Wang
, F. Marshall
, R.C. Stevens

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands. © 2013 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	12-22
Journal	Trends in Pharmacological Sciences
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.tips.2013.11.001
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.tips.2013.11.001

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Secretin-like class B G protein-coupled receptor (GPCR) mutation data set
de Graaf, C. (Contributor), Unknown, 1 Jan 2014
DOI: 10.5281/zenodo.60790, https://zenodo.org/record/60790
Dataset / Software: Dataset

Cite this

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doi = "10.1016/j.tips.2013.11.001",

language = "English",

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T1 - New insights into the structure of Class B G protein-coupled receptors

AU - Hollenstein, H.

AU - de Graaf, C.

AU - Bortolato, A.

AU - Wang, M-W

AU - Marshall, F.

AU - Stevens, R.C.

PY - 2014

Y1 - 2014

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AB - The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands. © 2013 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tips.2013.11.001

DO - 10.1016/j.tips.2013.11.001

M3 - Article

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VL - 35

SP - 12

EP - 22

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 1

ER -

New insights into the structure of Class B G protein-coupled receptors

Abstract

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Datasets

Secretin-like class B G protein-coupled receptor (GPCR) mutation data set

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