New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

M. Horikoshi; H. Yaghootkar; D.O. Mook-Kanamori; U. Sovio; H.R. Taal; B.J. Hennig; J.P. Bradfield; B. St Pourcain; D.M. Evans; P. Charoen; M. Kaakinen; D.L. Cousminer; T. Lehtimäki; E. Kreiner-Møller; N.M. Warrington; M. Bustamante; B. Feenstra; D.J. Berry; E. Thiering; T. Pfab; S.J. Barton; B.M. Shields; M. Kerkhof; E. M. Leeuwen; A.J. Fulford; Z. Kutalik; J.H. Zhao; M. van den Hoed; A. Mahajan; V. Lindi; L.K. Goh; J.J. Hottenga; Y. Wu; O.T. Raitakari; M.N. Harder; A. Meirhaeghe; I. Ntalla; R.M. Salem; K.A. Jameson; K. Zhou; D.M. Monies; V. Lagou; M. Kirin; J. Heikkinen; L.S. Adair; F.S. Alkuraya; A. Al-Odaib; P. Amouyel; E.A. Andersson; A.J. Bennett; A.I.F. Blakemore; J.L. Buxton; J. Dallongeville; S. Das; E.J.C. de Geus; X. Estivill; C. Flexeder; P. Froguel; F. Geller; K.M. Godfrey; F. Gottrand; C.J. Groves; T. Hansen; J.N. Hirschhorn; A. Hofman; M.V. Hollegaard; D. M. Hougaard; E. Hyppönen; H.M. Inskip; A. Isaacs; T. Jørgensen; C. Kanaka-Gantenbein; J.P. Kemp; W. Kiess; T.O. Kilpeläinen; N. Klopp; B.A. Knight; C.W. Kuzawa; G. McMahon; J.P. Newnham; H. Niinikoski; B.A. Oostra; L. Pedersen; D.S. Postma; S.M. Ring; F. Rivadeneira; N.R. Robertson; S. Sebert; O. Simell; T. Slowinski; C.M.T. Tiesler; A. Tönjes; A.A. Vaag; J.S. Viikari; J.M. Vink; N.H. Vissing; N.J. Wareham; G. Willemsen; D.R. Witte; H. Zhang; J. Zhao; J.F. Wilson; M. Stumvoll; A.M. Prentice; B.F. Meyer; E.R. Pearson; C.A. Boreham; C. Cooper; M.W. Gillman; G.V. Dedoussis; L.A. Moreno; O. Pedersen; M. Saarinen; K.L. Mohlke; D.I. Boomsma; S.M. Saw; T.A. Lakka; A. Körner; R.J. Loos; K.K. Ong; P. Vollenweider; C.M. van Duijn; G.H. Koppelman; A.T. Hattersley; J.W. Holloway; B. Hocher; J. Heinrich; C. Power; M. Melbye; M. Guxens; C.E. Pennell; K. Bønnelykke; H. Bisgaard; J.G. Eriksson; E. Widén; H. Hakonarson; A.G. Uitterlinden; A. Pouta; D.A. Lawlor; G.D. Smith; T.M. Frayling; M.I. McCarthy; S.F. Grant; V.W. Jaddoe; M.R. Järvelin; N.J. Timpson; I. Prokopenko; R.M. Freathy

doi:10.1038/ng.2477

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

M. Horikoshi, H. Yaghootkar, D.O. Mook-Kanamori, U. Sovio, H.R. Taal, B.J. Hennig, J.P. Bradfield, B. St Pourcain, D.M. Evans, P. Charoen, M. Kaakinen, D.L. Cousminer, T. Lehtimäki, E. Kreiner-Møller, N.M. Warrington, M. Bustamante, B. Feenstra, D.J. Berry, E. Thiering, T. PfabS.J. Barton, B.M. Shields, M. Kerkhof, E. M. Leeuwen, A.J. Fulford, Z. Kutalik, J.H. Zhao, M. van den Hoed, A. Mahajan, V. Lindi, L.K. Goh, J.J. Hottenga, Y. Wu, O.T. Raitakari, M.N. Harder, A. Meirhaeghe, I. Ntalla, R.M. Salem, K.A. Jameson, K. Zhou, D.M. Monies, V. Lagou, M. Kirin, J. Heikkinen, L.S. Adair, F.S. Alkuraya, A. Al-Odaib, P. Amouyel, E.A. Andersson, A.J. Bennett, A.I.F. Blakemore, J.L. Buxton, J. Dallongeville, S. Das, E.J.C. de Geus, X. Estivill, C. Flexeder, P. Froguel, F. Geller, K.M. Godfrey, F. Gottrand, C.J. Groves, T. Hansen, J.N. Hirschhorn, A. Hofman, M.V. Hollegaard, D. M. Hougaard, E. Hyppönen, H.M. Inskip, A. Isaacs, T. Jørgensen, C. Kanaka-Gantenbein, J.P. Kemp, W. Kiess, T.O. Kilpeläinen, N. Klopp, B.A. Knight, C.W. Kuzawa, G. McMahon, J.P. Newnham, H. Niinikoski, B.A. Oostra, L. Pedersen, D.S. Postma, S.M. Ring, F. Rivadeneira, N.R. Robertson, S. Sebert, O. Simell, T. Slowinski, C.M.T. Tiesler, A. Tönjes, A.A. Vaag, J.S. Viikari, J.M. Vink, N.H. Vissing, N.J. Wareham, G. Willemsen, D.R. Witte, H. Zhang, J. Zhao, J.F. Wilson, M. Stumvoll, A.M. Prentice, B.F. Meyer, E.R. Pearson, C.A. Boreham, C. Cooper, M.W. Gillman, G.V. Dedoussis, L.A. Moreno, O. Pedersen, M. Saarinen, K.L. Mohlke, D.I. Boomsma, S.M. Saw, T.A. Lakka, A. Körner, R.J. Loos, K.K. Ong, P. Vollenweider, C.M. van Duijn, G.H. Koppelman, A.T. Hattersley, J.W. Holloway, B. Hocher, J. Heinrich, C. Power, M. Melbye, M. Guxens, C.E. Pennell, K. Bønnelykke, H. Bisgaard, J.G. Eriksson, E. Widén, H. Hakonarson, A.G. Uitterlinden, A. Pouta, D.A. Lawlor, G.D. Smith, T.M. Frayling, M.I. McCarthy, S.F. Grant, V.W. Jaddoe, M.R. Järvelin, N.J. Timpson, I. Prokopenko, R.M. Freathy

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	76-82
Journal	Nature Genetics
Volume	45
Issue number	1
DOIs	https://doi.org/10.1038/ng.2477
Publication status	Published - 2013

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.2477

Handle.net

Persistent link

Cite this

Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., ... Freathy, R. M. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76-82. https://doi.org/10.1038/ng.2477

@article{1621ee2fb464487fb4687d7412d26dd4,

title = "New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism",

abstract = "Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. {\textcopyright} 2013 Nature America, Inc. All rights reserved.",

author = "M. Horikoshi and H. Yaghootkar and D.O. Mook-Kanamori and U. Sovio and H.R. Taal and B.J. Hennig and J.P. Bradfield and {St Pourcain}, B. and D.M. Evans and P. Charoen and M. Kaakinen and D.L. Cousminer and T. Lehtim{\"a}ki and E. Kreiner-M{\o}ller and N.M. Warrington and M. Bustamante and B. Feenstra and D.J. Berry and E. Thiering and T. Pfab and S.J. Barton and B.M. Shields and M. Kerkhof and Leeuwen, {E. M.} and A.J. Fulford and Z. Kutalik and J.H. Zhao and {van den Hoed}, M. and A. Mahajan and V. Lindi and L.K. Goh and J.J. Hottenga and Y. Wu and O.T. Raitakari and M.N. Harder and A. Meirhaeghe and I. Ntalla and R.M. Salem and K.A. Jameson and K. Zhou and D.M. Monies and V. Lagou and M. Kirin and J. Heikkinen and L.S. Adair and F.S. Alkuraya and A. Al-Odaib and P. Amouyel and E.A. Andersson and A.J. Bennett and A.I.F. Blakemore and J.L. Buxton and J. Dallongeville and S. Das and {de Geus}, E.J.C. and X. Estivill and C. Flexeder and P. Froguel and F. Geller and K.M. Godfrey and F. Gottrand and C.J. Groves and T. Hansen and J.N. Hirschhorn and A. Hofman and M.V. Hollegaard and Hougaard, {D. M.} and E. Hypp{\"o}nen and H.M. Inskip and A. Isaacs and T. J{\o}rgensen and C. Kanaka-Gantenbein and J.P. Kemp and W. Kiess and T.O. Kilpel{\"a}inen and N. Klopp and B.A. Knight and C.W. Kuzawa and G. McMahon and J.P. Newnham and H. Niinikoski and B.A. Oostra and L. Pedersen and D.S. Postma and S.M. Ring and F. Rivadeneira and N.R. Robertson and S. Sebert and O. Simell and T. Slowinski and C.M.T. Tiesler and A. T{\"o}njes and A.A. Vaag and J.S. Viikari and J.M. Vink and N.H. Vissing and N.J. Wareham and G. Willemsen and D.R. Witte and H. Zhang and J. Zhao and J.F. Wilson and M. Stumvoll and A.M. Prentice and B.F. Meyer and E.R. Pearson and C.A. Boreham and C. Cooper and M.W. Gillman and G.V. Dedoussis and L.A. Moreno and O. Pedersen and M. Saarinen and K.L. Mohlke and D.I. Boomsma and S.M. Saw and T.A. Lakka and A. K{\"o}rner and R.J. Loos and K.K. Ong and P. Vollenweider and {van Duijn}, C.M. and G.H. Koppelman and A.T. Hattersley and J.W. Holloway and B. Hocher and J. Heinrich and C. Power and M. Melbye and M. Guxens and C.E. Pennell and K. B{\o}nnelykke and H. Bisgaard and J.G. Eriksson and E. Wid{\'e}n and H. Hakonarson and A.G. Uitterlinden and A. Pouta and D.A. Lawlor and G.D. Smith and T.M. Frayling and M.I. McCarthy and S.F. Grant and V.W. Jaddoe and M.R. J{\"a}rvelin and N.J. Timpson and I. Prokopenko and R.M. Freathy",

year = "2013",

doi = "10.1038/ng.2477",

language = "English",

volume = "45",

pages = "76--82",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "1",

}

Horikoshi, M, Yaghootkar, H, Mook-Kanamori, DO, Sovio, U, Taal, HR, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtimäki, T, Kreiner-Møller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, Leeuwen, EM, Fulford, AJ, Kutalik, Z, Zhao, JH, van den Hoed, M, Mahajan, A, Lindi, V, Goh, LK, Hottenga, JJ, Wu, Y, Raitakari, OT, Harder, MN, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K, Monies, DM, Lagou, V, Kirin, M, Heikkinen, J, Adair, LS, Alkuraya, FS, Al-Odaib, A, Amouyel, P, Andersson, EA, Bennett, AJ, Blakemore, AIF, Buxton, JL, Dallongeville, J, Das, S, de Geus, EJC, Estivill, X, Flexeder, C, Froguel, P, Geller, F, Godfrey, KM, Gottrand, F, Groves, CJ, Hansen, T, Hirschhorn, JN, Hofman, A, Hollegaard, MV, Hougaard, DM, Hyppönen, E, Inskip, HM, Isaacs, A, Jørgensen, T, Kanaka-Gantenbein, C, Kemp, JP, Kiess, W, Kilpeläinen, TO, Klopp, N, Knight, BA, Kuzawa, CW, McMahon, G, Newnham, JP, Niinikoski, H, Oostra, BA, Pedersen, L, Postma, DS, Ring, SM, Rivadeneira, F, Robertson, NR, Sebert, S, Simell, O, Slowinski, T, Tiesler, CMT, Tönjes, A, Vaag, AA, Viikari, JS, Vink, JM, Vissing, NH, Wareham, NJ, Willemsen, G, Witte, DR, Zhang, H, Zhao, J, Wilson, JF, Stumvoll, M, Prentice, AM, Meyer, BF, Pearson, ER, Boreham, CA, Cooper, C, Gillman, MW, Dedoussis, GV, Moreno, LA, Pedersen, O, Saarinen, M, Mohlke, KL, Boomsma, DI, Saw, SM, Lakka, TA, Körner, A, Loos, RJ, Ong, KK, Vollenweider, P, van Duijn, CM, Koppelman, GH, Hattersley, AT, Holloway, JW, Hocher, B, Heinrich, J, Power, C, Melbye, M, Guxens, M, Pennell, CE, Bønnelykke, K, Bisgaard, H, Eriksson, JG, Widén, E, Hakonarson, H, Uitterlinden, AG, Pouta, A, Lawlor, DA, Smith, GD, Frayling, TM, McCarthy, MI, Grant, SF, Jaddoe, VW, Järvelin, MR, Timpson, NJ, Prokopenko, I & Freathy, RM 2013, 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', Nature Genetics, vol. 45, no. 1, pp. 76-82. https://doi.org/10.1038/ng.2477

TY - JOUR

T1 - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

AU - Horikoshi, M.

AU - Yaghootkar, H.

AU - Mook-Kanamori, D.O.

AU - Sovio, U.

AU - Taal, H.R.

AU - Hennig, B.J.

AU - Bradfield, J.P.

AU - St Pourcain, B.

AU - Evans, D.M.

AU - Charoen, P.

AU - Kaakinen, M.

AU - Cousminer, D.L.

AU - Lehtimäki, T.

AU - Kreiner-Møller, E.

AU - Warrington, N.M.

AU - Bustamante, M.

AU - Feenstra, B.

AU - Berry, D.J.

AU - Thiering, E.

AU - Pfab, T.

AU - Barton, S.J.

AU - Shields, B.M.

AU - Kerkhof, M.

AU - Leeuwen, E. M.

AU - Fulford, A.J.

AU - Kutalik, Z.

AU - Zhao, J.H.

AU - van den Hoed, M.

AU - Mahajan, A.

AU - Lindi, V.

AU - Goh, L.K.

AU - Hottenga, J.J.

AU - Wu, Y.

AU - Raitakari, O.T.

AU - Harder, M.N.

AU - Meirhaeghe, A.

AU - Ntalla, I.

AU - Salem, R.M.

AU - Jameson, K.A.

AU - Zhou, K.

AU - Monies, D.M.

AU - Lagou, V.

AU - Kirin, M.

AU - Heikkinen, J.

AU - Adair, L.S.

AU - Alkuraya, F.S.

AU - Al-Odaib, A.

AU - Amouyel, P.

AU - Andersson, E.A.

AU - Bennett, A.J.

AU - Blakemore, A.I.F.

AU - Buxton, J.L.

AU - Dallongeville, J.

AU - Das, S.

AU - de Geus, E.J.C.

AU - Estivill, X.

AU - Flexeder, C.

AU - Froguel, P.

AU - Geller, F.

AU - Godfrey, K.M.

AU - Gottrand, F.

AU - Groves, C.J.

AU - Hansen, T.

AU - Hirschhorn, J.N.

AU - Hofman, A.

AU - Hollegaard, M.V.

AU - Hougaard, D. M.

AU - Hyppönen, E.

AU - Inskip, H.M.

AU - Isaacs, A.

AU - Jørgensen, T.

AU - Kanaka-Gantenbein, C.

AU - Kemp, J.P.

AU - Kiess, W.

AU - Kilpeläinen, T.O.

AU - Klopp, N.

AU - Knight, B.A.

AU - Kuzawa, C.W.

AU - McMahon, G.

AU - Newnham, J.P.

AU - Niinikoski, H.

AU - Oostra, B.A.

AU - Pedersen, L.

AU - Postma, D.S.

AU - Ring, S.M.

AU - Rivadeneira, F.

AU - Robertson, N.R.

AU - Sebert, S.

AU - Simell, O.

AU - Slowinski, T.

AU - Tiesler, C.M.T.

AU - Tönjes, A.

AU - Vaag, A.A.

AU - Viikari, J.S.

AU - Vink, J.M.

AU - Vissing, N.H.

AU - Wareham, N.J.

AU - Willemsen, G.

AU - Witte, D.R.

AU - Zhang, H.

AU - Zhao, J.

AU - Wilson, J.F.

AU - Stumvoll, M.

AU - Prentice, A.M.

AU - Meyer, B.F.

AU - Pearson, E.R.

AU - Boreham, C.A.

AU - Cooper, C.

AU - Gillman, M.W.

AU - Dedoussis, G.V.

AU - Moreno, L.A.

AU - Pedersen, O.

AU - Saarinen, M.

AU - Mohlke, K.L.

AU - Boomsma, D.I.

AU - Saw, S.M.

AU - Lakka, T.A.

AU - Körner, A.

AU - Loos, R.J.

AU - Ong, K.K.

AU - Vollenweider, P.

AU - van Duijn, C.M.

AU - Koppelman, G.H.

AU - Hattersley, A.T.

AU - Holloway, J.W.

AU - Hocher, B.

AU - Heinrich, J.

AU - Power, C.

AU - Melbye, M.

AU - Guxens, M.

AU - Pennell, C.E.

AU - Bønnelykke, K.

AU - Bisgaard, H.

AU - Eriksson, J.G.

AU - Widén, E.

AU - Hakonarson, H.

AU - Uitterlinden, A.G.

AU - Pouta, A.

AU - Lawlor, D.A.

AU - Smith, G.D.

AU - Frayling, T.M.

AU - McCarthy, M.I.

AU - Grant, S.F.

AU - Jaddoe, V.W.

AU - Järvelin, M.R.

AU - Timpson, N.J.

AU - Prokopenko, I.

AU - Freathy, R.M.

PY - 2013

Y1 - 2013

N2 - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.

AB - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.2477

DO - 10.1038/ng.2477

M3 - Article

SN - 1061-4036

VL - 45

SP - 76

EP - 82

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Abstract

Cohort Studies

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this