New Modalities for Challenging Targets in Drug Discovery

Eric Valeur, Stéphanie M. Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N. Grossmann, Alleyn T. Plowright

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

An ever increasing understanding of biological systems is providing a range of exciting novel biological targets whose modulation may enable novel therapeutic options in many diseases. These targets include protein-protein and protein-nucleic acid interactions, which are, however, often refractory to classical small molecule approaches. Other types of molecules, or modalities, are therefore required to address these targets, which has led several academic research groups and pharmaceutical companies to increasingly use the concept of so-called 'New Modalities'. This review defines for the first time the scope of this term, which includes novel peptidic scaffolds, oligonucleotides, hybrids, molecular conjugates as well as new uses of classical small molecules. We provide herein a journey through the most representative examples of these modalities to target large binding surface areas such as those found in protein-protein interactions and for biological processes at the center of cell regulation.
Original languageEnglish
Pages (from-to)10294–10323
JournalAngewandte Chemie International Edition in English
Volume56
DOIs
Publication statusPublished - 21 Aug 2017

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Proteins
Molecules
Oligonucleotides
Nucleic acids
Biological systems
Scaffolds
Refractory materials
Drug products
Nucleic Acids
Modulation
Drug Discovery
Pharmaceutical Preparations
Industry

Keywords

  • drug conjugates
  • macrocycles
  • oligonucleotides
  • peptides

Cite this

Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., ... Plowright, A. T. (2017). New Modalities for Challenging Targets in Drug Discovery. Angewandte Chemie International Edition in English, 56, 10294–10323. https://doi.org/10.1002/anie.201611914
Valeur, Eric ; Guéret, Stéphanie M. ; Adihou, Hélène ; Gopalakrishnan, Ranganath ; Lemurell, Malin ; Waldmann, Herbert ; Grossmann, Tom N. ; Plowright, Alleyn T. / New Modalities for Challenging Targets in Drug Discovery. In: Angewandte Chemie International Edition in English. 2017 ; Vol. 56. pp. 10294–10323.
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Valeur, E, Guéret, SM, Adihou, H, Gopalakrishnan, R, Lemurell, M, Waldmann, H, Grossmann, TN & Plowright, AT 2017, 'New Modalities for Challenging Targets in Drug Discovery' Angewandte Chemie International Edition in English, vol. 56, pp. 10294–10323. https://doi.org/10.1002/anie.201611914

New Modalities for Challenging Targets in Drug Discovery. / Valeur, Eric; Guéret, Stéphanie M.; Adihou, Hélène; Gopalakrishnan, Ranganath; Lemurell, Malin; Waldmann, Herbert; Grossmann, Tom N.; Plowright, Alleyn T.

In: Angewandte Chemie International Edition in English, Vol. 56, 21.08.2017, p. 10294–10323.

Research output: Contribution to JournalReview articleAcademicpeer-review

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Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H et al. New Modalities for Challenging Targets in Drug Discovery. Angewandte Chemie International Edition in English. 2017 Aug 21;56:10294–10323. https://doi.org/10.1002/anie.201611914