New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment

Antonella Riva, Alice Golda, Ganna Balagura, Elisabetta Amadori, Maria Stella Vari, Gianluca Piccolo, Michele Iacomino, Simona Lattanzi, Vincenzo Salpietro, Carlo Minetti, Pasquale Striano*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of patients with epilepsy retain persistent seizures with a significant burden in comorbidity and an increased risk of premature death. This review aims to discuss the therapeutic strategies, both pharmacological and non-, which are currently in the pipeline. Methods: PubMed, Scopus, and EMBASE databases were screened for experimental and clinical studies, meta-analysis, and structured reviews published between January 2018 and September 2021. The terms “epilepsy,” “treatment” or “therapy,” and “novel” were used to filter the results. Conclusions: The common feature linking all the novel therapeutic approaches is the spasmodic rush toward precision medicine, aiming at holistically evaluating patients, and treating them accordingly as a whole. Toward this goal, different forms of intervention may be embraced, starting from the choice of the most suitable drug according to the type of epilepsy of an individual or expected adverse effects, to the outstanding field of gene therapy. Moreover, innovative insights come from in-vitro and in-vivo studies on the role of inflammation and stem cells in the brain. Further studies on both efficacy and safety are needed, with the challenge to mature evidence into reliable assets, ameliorating the symptoms of patients, and answering the challenges of this disease.

Original languageEnglish
Article number753753
Pages (from-to)1-14
Number of pages14
JournalFrontiers in Neurology
Issue numberDecember
Early online date7 Dec 2021
Publication statusPublished - Dec 2021

Bibliographical note

Funding Information:
This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018-2022 (legge 232 del 2016).

Publisher Copyright:
Copyright © 2021 Riva, Golda, Balagura, Amadori, Vari, Piccolo, Iacomino, Lattanzi, Salpietro, Minetti and Striano.


  • anti-seizure medications
  • epilepsy
  • genetics
  • inflammation
  • precision medicine


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