Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

P.H.N. Celie, S.E. van Rossum-Fikkert, W. van Dijk, K. Brejc, A.B. Smit, T.K. Sixma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABA
Original languageEnglish
Pages (from-to)907-915
Number of pages8
JournalNeuron
Volume41
DOIs
Publication statusPublished - 2004

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