Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

P.H.N. Celie; S.E. van Rossum-Fikkert; W. van Dijk; K. Brejc; A.B. Smit; T.K. Sixma

doi:10.1016/S0896-6273(04)00115-1

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

P.H.N. Celie, S.E. van Rossum-Fikkert, W. van Dijk, K. Brejc, A.B. Smit, T.K. Sixma

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABA

Original language	English
Pages (from-to)	907-915
Number of pages	8
Journal	Neuron
Volume	41
DOIs	https://doi.org/10.1016/S0896-6273(04)00115-1
Publication status	Published - 2004

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10.1016/S0896-6273(04)00115-1

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title = "Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures",

abstract = "Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABA",

author = "P.H.N. Celie and {van Rossum-Fikkert}, S.E. and {van Dijk}, W. and K. Brejc and A.B. Smit and T.K. Sixma",

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AU - Celie, P.H.N.

AU - van Rossum-Fikkert, S.E.

AU - van Dijk, W.

AU - Brejc, K.

AU - Smit, A.B.

AU - Sixma, T.K.

PY - 2004

Y1 - 2004

N2 - Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABA

AB - Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble homolog of the ligand binding domain of nicotinic receptors and their family members, GABA

U2 - 10.1016/S0896-6273(04)00115-1

DO - 10.1016/S0896-6273(04)00115-1

M3 - Article

SN - 0896-6273

VL - 41

SP - 907

EP - 915

JO - Neuron

JF - Neuron

ER -

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

Abstract

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