Nitrilium ions-synthesis and applications

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Nitrilium ions have been well-established in organic chemistry for many decades, but recent developments show them to be far more versatile than hitherto recognized. They are known as stable salts, can be generated in situ, or are present as transient intermediates. We provide a succinct, but comprehensive review on the synthesis, stability, and reactivity of nitrilium ions as synthons for imines, their use in the synthesis of a large spectrum of heterocycles, and their reactions with transition metal complexes. By offering this overview, we aim for a renewed focus on readily accessible and simple to use nitrilium ions as valuable reagents for the synthesis of organic compounds.

Original languageEnglish
Pages (from-to)10134-10144
Number of pages11
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number48
DOIs
Publication statusPublished - 2017

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Ions
synthesis
Organic Chemistry
organic chemistry
Synthetic Chemistry Techniques
ions
Imines
Coordination Complexes
organic compounds
Organic compounds
imines
Transition metals
reagents
reactivity
Salts
transition metals
salts

Cite this

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title = "Nitrilium ions-synthesis and applications",
abstract = "Nitrilium ions have been well-established in organic chemistry for many decades, but recent developments show them to be far more versatile than hitherto recognized. They are known as stable salts, can be generated in situ, or are present as transient intermediates. We provide a succinct, but comprehensive review on the synthesis, stability, and reactivity of nitrilium ions as synthons for imines, their use in the synthesis of a large spectrum of heterocycles, and their reactions with transition metal complexes. By offering this overview, we aim for a renewed focus on readily accessible and simple to use nitrilium ions as valuable reagents for the synthesis of organic compounds.",
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Nitrilium ions-synthesis and applications. / Van Dijk, Tom; Slootweg, J.Chris ; Lammertsma, Koop.

In: Organic and Biomolecular Chemistry, Vol. 15, No. 48, 2017, p. 10134-10144.

Research output: Contribution to JournalReview articleAcademicpeer-review

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