NMR in structure-based drug design

Marta G. Carneiro, A. B. Eiso, Stephan Theisgen, Gregg Siegal*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed.

Original languageEnglish
Pages (from-to)485-493
Number of pages9
JournalEssays in Biochemistry
Issue number5
Publication statusPublished - 8 Nov 2017
Externally publishedYes


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