No association between glucocorticoid diurnal rhythm in breastmilk and infant body composition at 3 months

Jonneke Hollanders; Lisette R. Dijkstra; Bibian Van Der Voorn; Stefanie M.P. Kouwenhoven; Alyssa A. Toorop; Johannes B. Van Goudoever; Joost Rotteveel; Martijn J.J. Finken

doi:10.3390/nu11102351

No association between glucocorticoid diurnal rhythm in breastmilk and infant body composition at 3 months

Jonneke Hollanders^*
, Lisette R. Dijkstra
, Bibian Van Der Voorn
, Stefanie M.P. Kouwenhoven
, Alyssa A. Toorop
, Johannes B. Van Goudoever
, Joost Rotteveel
, Martijn J.J. Finken

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant’s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.

Original language	English
Article number	2351
Pages (from-to)	1-9
Number of pages	9
Journal	Nutrients
Volume	11
Issue number	10
Early online date	2 Oct 2019
DOIs	https://doi.org/10.3390/nu11102351
Publication status	Published - Oct 2019
Externally published	Yes

Bibliographical note

Funding Information:
The study participants, for giving their time and energy to this study. D.L. for including mother-infant pairs and analyzing breastmilk and saliva samples. A.C.H., F.M., A.F. and other colleagues at the endocrinology laboratory for their contribution to the GC analyses.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Funding

The study participants, for giving their time and energy to this study. D.L. for including mother-infant pairs and analyzing breastmilk and saliva samples. A.C.H., F.M., A.F. and other colleagues at the endocrinology laboratory for their contribution to the GC analyses.

Keywords

Circadian rhythm
Cortisol
Cortisone
Growth
Human milk

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10.3390/nu11102351

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@article{c0a879f117924661896bfb6f0ed75b7b,

title = "No association between glucocorticoid diurnal rhythm in breastmilk and infant body composition at 3 months",

abstract = "Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat\%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant{\textquoteright}s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.",

keywords = "Circadian rhythm, Cortisol, Cortisone, Growth, Human milk",

author = "Jonneke Hollanders and Dijkstra, \{Lisette R.\} and \{Van Der Voorn\}, Bibian and Kouwenhoven, \{Stefanie M.P.\} and Toorop, \{Alyssa A.\} and \{Van Goudoever\}, \{Johannes B.\} and Joost Rotteveel and Finken, \{Martijn J.J.\}",

note = "Funding Information: The study participants, for giving their time and energy to this study. D.L. for including mother-infant pairs and analyzing breastmilk and saliva samples. A.C.H., F.M., A.F. and other colleagues at the endocrinology laboratory for their contribution to the GC analyses. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = oct,

doi = "10.3390/nu11102351",

language = "English",

volume = "11",

pages = "1--9",

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AU - Hollanders, Jonneke

AU - Dijkstra, Lisette R.

AU - Van Der Voorn, Bibian

AU - Kouwenhoven, Stefanie M.P.

AU - Toorop, Alyssa A.

AU - Van Goudoever, Johannes B.

AU - Rotteveel, Joost

AU - Finken, Martijn J.J.

N1 - Funding Information: The study participants, for giving their time and energy to this study. D.L. for including mother-infant pairs and analyzing breastmilk and saliva samples. A.C.H., F.M., A.F. and other colleagues at the endocrinology laboratory for their contribution to the GC analyses. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant’s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.

AB - Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant’s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.

KW - Circadian rhythm

KW - Cortisol

KW - Cortisone

KW - Growth

KW - Human milk

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DO - 10.3390/nu11102351

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SN - 2072-6643

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SP - 1

EP - 9

JO - Nutrients

JF - Nutrients

IS - 10

M1 - 2351

ER -

No association between glucocorticoid diurnal rhythm in breastmilk and infant body composition at 3 months

Abstract

Bibliographical note

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Keywords

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