No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Hiromi Sawai; Nao Nishida; Hamdi Mbarek; Koichi Matsuda; Yoriko Mawatari; Megumi Yamaoka; Shuhei Hige; Jong-Hon Kang; Koichi Abe; Satoshi Mochida; Masaaki Watanabe; Masayuki Kurosaki; Yasuhiro Asahina; Namiki Izumi; Masao Honda; Shuichi Kaneko; Eiji Tanaka; Kentaro Matsuura; Yoshito Itoh; Eiji Mita; Masaaki Korenaga; Keisuke Hino; Yoshikazu Murawaki; Yoichi Hiasa; Tatsuya Ide; Kiyoaki Ito; Masaya Sugiyama; Sang Hoon Ahn; Kwang-Hyub Han; Jun Yong Park; Man-Fung Yuen; Yusuke Nakamura; Yasuhito Tanaka; Masashi Mizokami; Katsushi Tokunaga

doi:10.1186/1471-2350-13-47

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Hiromi Sawai, Nao Nishida, Hamdi Mbarek, Koichi Matsuda, Yoriko Mawatari, Megumi Yamaoka, Shuhei Hige, Jong-Hon Kang, Koichi Abe, Satoshi Mochida, Masaaki Watanabe, Masayuki Kurosaki, Yasuhiro Asahina, Namiki Izumi, Masao Honda, Shuichi Kaneko, Eiji Tanaka, Kentaro Matsuura, Yoshito Itoh, Eiji MitaMasaaki Korenaga, Keisuke Hino, Yoshikazu Murawaki, Yoichi Hiasa, Tatsuya Ide, Kiyoaki Ito, Masaya Sugiyama, Sang Hoon Ahn, Kwang-Hyub Han, Jun Yong Park, Man-Fung Yuen, Yusuke Nakamura, Yasuhito Tanaka, Masashi Mizokami, Katsushi Tokunaga

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.

RESULTS: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.

CONCLUSIONS: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

Original language	English
Pages (from-to)	47
Journal	BMC Medical Genetics
Volume	13
DOIs	https://doi.org/10.1186/1471-2350-13-47
Publication status	Published - 19 Jun 2012

Keywords

Asia
Carcinoma, Hepatocellular
China
Cohort Studies
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Neoplasms
Polymorphism, Single Nucleotide
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sawai, H., Nishida, N., Mbarek, H., Matsuda, K., Mawatari, Y., Yamaoka, M., Hige, S., Kang, J-H., Abe, K., Mochida, S., Watanabe, M., Kurosaki, M., Asahina, Y., Izumi, N., Honda, M., Kaneko, S., Tanaka, E., Matsuura, K., Itoh, Y., ... Tokunaga, K. (2012). No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. BMC Medical Genetics, 13, 47. https://doi.org/10.1186/1471-2350-13-47

@article{5f564e4cbe5648df97f72d2951458f60,

title = "No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations",

abstract = "BACKGROUND: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.RESULTS: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.CONCLUSIONS: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.",

keywords = "Asia, Carcinoma, Hepatocellular, China, Cohort Studies, Hepatitis B virus, Hepatitis B, Chronic, Humans, Liver Neoplasms, Polymorphism, Single Nucleotide, Journal Article, Research Support, Non-U.S. Gov't",

author = "Hiromi Sawai and Nao Nishida and Hamdi Mbarek and Koichi Matsuda and Yoriko Mawatari and Megumi Yamaoka and Shuhei Hige and Jong-Hon Kang and Koichi Abe and Satoshi Mochida and Masaaki Watanabe and Masayuki Kurosaki and Yasuhiro Asahina and Namiki Izumi and Masao Honda and Shuichi Kaneko and Eiji Tanaka and Kentaro Matsuura and Yoshito Itoh and Eiji Mita and Masaaki Korenaga and Keisuke Hino and Yoshikazu Murawaki and Yoichi Hiasa and Tatsuya Ide and Kiyoaki Ito and Masaya Sugiyama and Ahn, {Sang Hoon} and Kwang-Hyub Han and Park, {Jun Yong} and Man-Fung Yuen and Yusuke Nakamura and Yasuhito Tanaka and Masashi Mizokami and Katsushi Tokunaga",

year = "2012",

month = jun,

day = "19",

doi = "10.1186/1471-2350-13-47",

language = "English",

volume = "13",

pages = "47",

journal = "BMC Medical Genetics",

issn = "1471-2350",

publisher = "BioMed Central",

}

Sawai, H, Nishida, N, Mbarek, H, Matsuda, K, Mawatari, Y, Yamaoka, M, Hige, S, Kang, J-H, Abe, K, Mochida, S, Watanabe, M, Kurosaki, M, Asahina, Y, Izumi, N, Honda, M, Kaneko, S, Tanaka, E, Matsuura, K, Itoh, Y, Mita, E, Korenaga, M, Hino, K, Murawaki, Y, Hiasa, Y, Ide, T, Ito, K, Sugiyama, M, Ahn, SH, Han, K-H, Park, JY, Yuen, M-F, Nakamura, Y, Tanaka, Y, Mizokami, M & Tokunaga, K 2012, 'No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations', BMC Medical Genetics, vol. 13, pp. 47. https://doi.org/10.1186/1471-2350-13-47

TY - JOUR

T1 - No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

AU - Sawai, Hiromi

AU - Nishida, Nao

AU - Mbarek, Hamdi

AU - Matsuda, Koichi

AU - Mawatari, Yoriko

AU - Yamaoka, Megumi

AU - Hige, Shuhei

AU - Kang, Jong-Hon

AU - Abe, Koichi

AU - Mochida, Satoshi

AU - Watanabe, Masaaki

AU - Kurosaki, Masayuki

AU - Asahina, Yasuhiro

AU - Izumi, Namiki

AU - Honda, Masao

AU - Kaneko, Shuichi

AU - Tanaka, Eiji

AU - Matsuura, Kentaro

AU - Itoh, Yoshito

AU - Mita, Eiji

AU - Korenaga, Masaaki

AU - Hino, Keisuke

AU - Murawaki, Yoshikazu

AU - Hiasa, Yoichi

AU - Ide, Tatsuya

AU - Ito, Kiyoaki

AU - Sugiyama, Masaya

AU - Ahn, Sang Hoon

AU - Han, Kwang-Hyub

AU - Park, Jun Yong

AU - Yuen, Man-Fung

AU - Nakamura, Yusuke

AU - Tanaka, Yasuhito

AU - Mizokami, Masashi

AU - Tokunaga, Katsushi

PY - 2012/6/19

Y1 - 2012/6/19

N2 - BACKGROUND: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.RESULTS: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.CONCLUSIONS: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

AB - BACKGROUND: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.RESULTS: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.CONCLUSIONS: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

KW - Asia

KW - Carcinoma, Hepatocellular

KW - China

KW - Cohort Studies

KW - Hepatitis B virus

KW - Hepatitis B, Chronic

KW - Humans

KW - Liver Neoplasms

KW - Polymorphism, Single Nucleotide

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1471-2350-13-47

DO - 10.1186/1471-2350-13-47

M3 - Article

C2 - 22712471

SN - 1471-2350

VL - 13

SP - 47

JO - BMC Medical Genetics

JF - BMC Medical Genetics

ER -

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Abstract

Keywords

UN SDGs

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