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Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

  • I. Shemer
  • , C. Holmgren
  • , R. Min
  • , L. Fülöp
  • , M. Zilberter
  • , K.M. Sousa
  • , T. Farkas
  • , W. Härtig
  • , B. Penke
  • , N. Burnashev
  • , H. Tanila
  • , Z. Zilberter
  • , T. Harkany

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid β protein oligomers (Aβ
Original languageEnglish
Pages (from-to)2035-2047
Number of pages13
JournalEuropean Journal of Neuroscience
Volume23
Issue number8
DOIs
Publication statusPublished - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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