Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography

Boy Braaf, Kari V. Vienola, Koenraad A. Vermeer, Johannes F. de Boer

Research output: Contribution to ConferencePosterOther research output

Abstract

Introduction
Optical coherence tomography (OCT) uses laser interferometry for non-invasive cross-sectional imaging of tissues with micrometer resolution. This technology is therefore ideal to visualize the micro-structures of the human retina and choroid in vivo. Additionally blood flow can be detected from Doppler frequency shifts in the OCT signal over time, which are caused by moving particles in flowing blood. In this study we investigated if these Doppler shifts can be used to create angiograms of the retina and choroid.
Methods
An experimental OCT system was constructed based on a 1040 nm swept laser source. A healthy volunteer was imaged over a retinal area of 6.0 × 7.9 mm 2 (20º × 26º). Doppler shifts were evaluated by measuring each location twice and were calculated from phase changes within the OCT signals. Angiograms of the vasculature were created by integration of the phase changes over depth.

Results
The retinal angiogram (Fig. 1(A)) shows blood vessels (in white) down to the capillary level and visualizes clearly the avascular zone of the fovea and the entrance and exit of vessels through the optic disc. The choroidal angiogram (Fig. 1(B)) shows a dense network of large vessels below the retina.

Conclusions
Doppler OCT can produce high-resolution angiograms of the retina and choroid.
Original languageEnglish
Pages35-35
Number of pages1
Publication statusPublished - 8 Mar 2013
EventVU University Medical Center Science Exchange Day - VU University Medical Center, Amsterdam, Netherlands
Duration: 8 Mar 20138 Mar 2013

Conference

ConferenceVU University Medical Center Science Exchange Day
Abbreviated titleVUmc SED 2013
CountryNetherlands
CityAmsterdam
Period8/03/138/03/13

Fingerprint

angiography
retina
tomography
vessels
fovea
laser interferometry
shift
blood vessels
blood flow
entrances
frequency shift
blood
micrometers
optics
microstructure
high resolution
lasers

Keywords

  • optical coherence tomography
  • ophthalmic imaging
  • angiography

Cite this

Braaf, B., Vienola, K. V., Vermeer, K. A., & de Boer, J. F. (2013). Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography. 35-35. Poster session presented at VU University Medical Center Science Exchange Day, Amsterdam, Netherlands.
Braaf, Boy ; Vienola, Kari V. ; Vermeer, Koenraad A. ; de Boer, Johannes F. / Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography. Poster session presented at VU University Medical Center Science Exchange Day, Amsterdam, Netherlands.1 p.
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title = "Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography",
abstract = "IntroductionOptical coherence tomography (OCT) uses laser interferometry for non-invasive cross-sectional imaging of tissues with micrometer resolution. This technology is therefore ideal to visualize the micro-structures of the human retina and choroid in vivo. Additionally blood flow can be detected from Doppler frequency shifts in the OCT signal over time, which are caused by moving particles in flowing blood. In this study we investigated if these Doppler shifts can be used to create angiograms of the retina and choroid.MethodsAn experimental OCT system was constructed based on a 1040 nm swept laser source. A healthy volunteer was imaged over a retinal area of 6.0 × 7.9 mm 2 (20º × 26º). Doppler shifts were evaluated by measuring each location twice and were calculated from phase changes within the OCT signals. Angiograms of the vasculature were created by integration of the phase changes over depth.ResultsThe retinal angiogram (Fig. 1(A)) shows blood vessels (in white) down to the capillary level and visualizes clearly the avascular zone of the fovea and the entrance and exit of vessels through the optic disc. The choroidal angiogram (Fig. 1(B)) shows a dense network of large vessels below the retina.ConclusionsDoppler OCT can produce high-resolution angiograms of the retina and choroid.",
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Braaf, B, Vienola, KV, Vermeer, KA & de Boer, JF 2013, 'Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography' VU University Medical Center Science Exchange Day, Amsterdam, Netherlands, 8/03/13 - 8/03/13, pp. 35-35.

Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography. / Braaf, Boy; Vienola, Kari V.; Vermeer, Koenraad A.; de Boer, Johannes F.

2013. 35-35 Poster session presented at VU University Medical Center Science Exchange Day, Amsterdam, Netherlands.

Research output: Contribution to ConferencePosterOther research output

TY - CONF

T1 - Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography

AU - Braaf, Boy

AU - Vienola, Kari V.

AU - Vermeer, Koenraad A.

AU - de Boer, Johannes F.

PY - 2013/3/8

Y1 - 2013/3/8

N2 - IntroductionOptical coherence tomography (OCT) uses laser interferometry for non-invasive cross-sectional imaging of tissues with micrometer resolution. This technology is therefore ideal to visualize the micro-structures of the human retina and choroid in vivo. Additionally blood flow can be detected from Doppler frequency shifts in the OCT signal over time, which are caused by moving particles in flowing blood. In this study we investigated if these Doppler shifts can be used to create angiograms of the retina and choroid.MethodsAn experimental OCT system was constructed based on a 1040 nm swept laser source. A healthy volunteer was imaged over a retinal area of 6.0 × 7.9 mm 2 (20º × 26º). Doppler shifts were evaluated by measuring each location twice and were calculated from phase changes within the OCT signals. Angiograms of the vasculature were created by integration of the phase changes over depth.ResultsThe retinal angiogram (Fig. 1(A)) shows blood vessels (in white) down to the capillary level and visualizes clearly the avascular zone of the fovea and the entrance and exit of vessels through the optic disc. The choroidal angiogram (Fig. 1(B)) shows a dense network of large vessels below the retina.ConclusionsDoppler OCT can produce high-resolution angiograms of the retina and choroid.

AB - IntroductionOptical coherence tomography (OCT) uses laser interferometry for non-invasive cross-sectional imaging of tissues with micrometer resolution. This technology is therefore ideal to visualize the micro-structures of the human retina and choroid in vivo. Additionally blood flow can be detected from Doppler frequency shifts in the OCT signal over time, which are caused by moving particles in flowing blood. In this study we investigated if these Doppler shifts can be used to create angiograms of the retina and choroid.MethodsAn experimental OCT system was constructed based on a 1040 nm swept laser source. A healthy volunteer was imaged over a retinal area of 6.0 × 7.9 mm 2 (20º × 26º). Doppler shifts were evaluated by measuring each location twice and were calculated from phase changes within the OCT signals. Angiograms of the vasculature were created by integration of the phase changes over depth.ResultsThe retinal angiogram (Fig. 1(A)) shows blood vessels (in white) down to the capillary level and visualizes clearly the avascular zone of the fovea and the entrance and exit of vessels through the optic disc. The choroidal angiogram (Fig. 1(B)) shows a dense network of large vessels below the retina.ConclusionsDoppler OCT can produce high-resolution angiograms of the retina and choroid.

KW - optical coherence tomography

KW - ophthalmic imaging

KW - angiography

M3 - Poster

SP - 35

EP - 35

ER -

Braaf B, Vienola KV, Vermeer KA, de Boer JF. Non-invasive in vivo angiography of the human eye with Doppler Optical Coherence Tomography. 2013. Poster session presented at VU University Medical Center Science Exchange Day, Amsterdam, Netherlands.