Nonequilibrium microtubule fluctuations in a model cytoskeleton

C. P. Brangwynne, G.H. Koenderink, F.C. Mac Kintosh, D. A. Weitz

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Biological activity gives rise to nonequilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of embedded microtubules can be used to probe local stress fluctuations. We add myosin motors that drive the network out of equilibrium, resulting in an increased amplitude and modified time dependence of microtubule bending fluctuations. We show that this behavior results from steplike forces on the order of 10 pN driven by collective motor dynamics. © 2008 The American Physical Society.
Original languageEnglish
Article number118104
JournalPhysical Review Letters
Volume100
Issue number11
DOIs
Publication statusPublished - 21 Mar 2008

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Nonequilibrium microtubule fluctuations in a model cytoskeleton

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