Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

C.T. Gan; J.W. Lankhaar; N. Westerhof; J.T. Marcus; A. Becker; J.W.R. Twisk; A. Boonstra; P.E. Postmus; A. Vonk Noordegraaf

doi:10.1378/chest.07-1246

Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

C.T. Gan, J.W. Lankhaar, N. Westerhof, J.T. Marcus, A. Becker, J.W.R. Twisk, A. Boonstra, P.E. Postmus, A. Vonk Noordegraaf

Methodology and Applied Biostatistics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

Original language	English
Pages (from-to)	1906-1912
Journal	Chest
Volume	132
DOIs	https://doi.org/10.1378/chest.07-1246
Publication status	Published - 2007

Bibliographical note

Dec.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1378/chest.07-1246

Persistent URL (handle)

Copy link address

Cite this

@article{5d05b2350255435ab7c44348b2b725ad,

title = "Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .",

abstract = "Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm",

author = "C.T. Gan and J.W. Lankhaar and N. Westerhof and J.T. Marcus and A. Becker and J.W.R. Twisk and A. Boonstra and P.E. Postmus and {Vonk Noordegraaf}, A.",

note = "Dec.",

year = "2007",

doi = "10.1378/chest.07-1246",

language = "English",

volume = "132",

pages = "1906--1912",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

}

TY - JOUR

T1 - Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

AU - Gan, C.T.

AU - Lankhaar, J.W.

AU - Westerhof, N.

AU - Marcus, J.T.

AU - Becker, A.

AU - Twisk, J.W.R.

AU - Boonstra, A.

AU - Postmus, P.E.

AU - Vonk Noordegraaf, A.

N1 - Dec.

PY - 2007

Y1 - 2007

N2 - Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

AB - Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

U2 - 10.1378/chest.07-1246

DO - 10.1378/chest.07-1246

M3 - Article

SN - 0012-3692

VL - 132

SP - 1906

EP - 1912

JO - Chest

JF - Chest

ER -

Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

Abstract

Bibliographical note

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this