Nonlinear stress relaxation of transiently crosslinked biopolymer networks

Sihan Chen, Chase P. Broedersz, Tomer Markovich, Fred C. MacKintosh

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A long-standing puzzle in the rheology of living cells is the origin of the experimentally observed long-time stress relaxation. The mechanics of the cell is largely dictated by the cytoskeleton, which is a biopolymer network consisting of transient crosslinkers, allowing for stress relaxation over time. Moreover, these networks are internally stressed due to the presence of molecular motors. In this work we propose a theoretical model that uses a mode-dependent mobility to describe the stress relaxation of such prestressed transient networks. Our theoretical predictions agree favorably with experimental data of reconstituted cytoskeletal networks and may provide an explanation for the slow stress relaxation observed in cells.

Original languageEnglish
Article number034418
Pages (from-to)1-14
Number of pages14
JournalPhysical review E
Volume104
Issue number3
Early online date28 Sep 2021
DOIs
Publication statusPublished - Sep 2021

Bibliographical note

Funding Information:
This work was supported in part by the National Science Foundation Division of Materials Research (Grant No. DMR-1826623) and the National Science Foundation Center for Theoretical Biological Physics (Grant No. PHY-2019745). The authors acknowledge helpful discussions with G. Koenderink and Y. Mulla.

Publisher Copyright:
©2021 American Physical Society

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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