TY - JOUR
T1 - Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor
AU - de Kruijf, P.
AU - van Heteren, J.T.
AU - Lim, H.D.
AU - Conti, P.
AU - van der Lee, M.M.
AU - Bosch, L.
AU - Ho, K.K.
AU - Auld, D.S.
AU - Ohlmeyer, M.
AU - Smit, M.J.
AU - Wijkmans, J.C.
AU - Zaman, G.J.
AU - Leurs, R.
PY - 2009
Y1 - 2009
N2 - The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis; therefore, it is considered an attractive drug target. Different classes of small CXCR2 antagonists have been developed. In this study, we selected seven CXCR2 antagonists from the diarylurea, imida-zolylpyrimide, and thiazolopyrimidine class and studied their mechanisms of action at human CXCR2. All compounds are able to displace
AB - The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis; therefore, it is considered an attractive drug target. Different classes of small CXCR2 antagonists have been developed. In this study, we selected seven CXCR2 antagonists from the diarylurea, imida-zolylpyrimide, and thiazolopyrimidine class and studied their mechanisms of action at human CXCR2. All compounds are able to displace
UR - https://www.scopus.com/pages/publications/65649101821
UR - https://www.scopus.com/inward/citedby.url?scp=65649101821&partnerID=8YFLogxK
U2 - 10.1124/jpet.108.148387
DO - 10.1124/jpet.108.148387
M3 - Article
SN - 0022-3565
VL - 329
SP - 783
EP - 790
JO - The Journal of Pharmacology and Experimental Therapeutics
JF - The Journal of Pharmacology and Experimental Therapeutics
IS - 2
ER -
