Novel Candidate Genes Associated with Hippocampal Oscillations

R. Jansen, J. Timmerman, M. Loos, S. Spijker, A. van Ooijen, A.B. Brussaard, H.D. Mansvelder, A.B. Smit, M.C.M. de Gunst, K. Linkenkaer-Hansen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration. © 2011 Jansen et al.
Original languageEnglish
Article numbere26586
JournalPLoS ONE
Volume6
Issue number10
DOIs
Publication statusPublished - 2011

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oscillation
Genes
Quantitative Trait Loci
Genome
genome
quantitative trait loci
Inbred Strains Mice
genes
Phospholipases
Carbachol
Calcium Channels
carbachol
calcium channels
Hippocampus
Electrodes
hippocampus
electrodes
Gene Expression
Correlation methods
Gene expression

Cite this

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title = "Novel Candidate Genes Associated with Hippocampal Oscillations",
abstract = "The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration. {\circledC} 2011 Jansen et al.",
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year = "2011",
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language = "English",
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Novel Candidate Genes Associated with Hippocampal Oscillations. / Jansen, R.; Timmerman, J.; Loos, M.; Spijker, S.; van Ooijen, A.; Brussaard, A.B.; Mansvelder, H.D.; Smit, A.B.; de Gunst, M.C.M.; Linkenkaer-Hansen, K.

In: PLoS ONE, Vol. 6, No. 10, e26586, 2011.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Novel Candidate Genes Associated with Hippocampal Oscillations

AU - Jansen, R.

AU - Timmerman, J.

AU - Loos, M.

AU - Spijker, S.

AU - van Ooijen, A.

AU - Brussaard, A.B.

AU - Mansvelder, H.D.

AU - Smit, A.B.

AU - de Gunst, M.C.M.

AU - Linkenkaer-Hansen, K.

PY - 2011

Y1 - 2011

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AB - The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration. © 2011 Jansen et al.

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