Novel genetic loci associated with hippocampal volume

Derrek P Hibar, Hieab H H Adams, Neda Jahanshad, Ganesh Chauhan, Jason L Stein, Edith Hofer, Miguel E Renteria, Joshua C Bis, Alejandro Arias-Vasquez, M Kamran Ikram, Sylvane Desrivières, Meike W Vernooij, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, Nicola J Armstrong, Lavinia Athanasiu & 312 others Tomas Axelsson, Ashley H Beecham, Alexa Beiser, Manon Bernard, Susan H Blanton, Marc M Bohlken, Marco P Boks, Janita Bralten, Adam M Brickman, Owen Carmichael, M Mallar Chakravarty, Qiang Chen, Christopher R K Ching, Vincent Chouraki, Gabriel Cuellar-Partida, Fabrice Crivello, Anouk Den Braber, Nhat Trung Doan, Stefan Ehrlich, Sudheer Giddaluru, Aaron L Goldman, Rebecca F Gottesman, Oliver Grimm, Michael E Griswold, Tulio Guadalupe, Boris A Gutman, Johanna Hass, Unn K Haukvik, David Hoehn, Avram J Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Kjetil N Jørgensen, Nazanin Karbalai, Dalia Kasperaviciute, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H Lee, David C M Liewald, Lorna M Lopez, Michelle Luciano, Christine Macare, Andre F Marquand, Mar Matarin, Karen A Mather, Manuel Mattheisen, David R McKay, Yuri Milaneschi, Susana Muñoz Maniega, Kwangsik Nho, Allison C Nugent, Paul Nyquist, Loes M Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Lukas Pirpamer, Benno Pütz, Adaikalavan Ramasamy, Jennifer S Richards, Shannon L Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Stefan Ropele, Emma J Rose, Natalie A Royle, Tatjana Rundek, Philipp G Sämann, Arvin Saremi, Claudia L Satizabal, Lianne Schmaal, Andrew J Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V Smith, Emma Sprooten, Lachlan T Strike, Alexander Teumer, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Stella Trompet, Dhananjay Vaidya, Jeroen Van Der Grond, Sven J Van der Lee, Dennis Van der Meer, Marjolein M J Van Donkelaar, Kristel R Van Eijk, Theo G M Van Erp, Daan Van Rooij, Esther Walton, Lars T Westlye, Christopher D Whelan, Beverly G Windham, Anderson M Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Lisa R Yanek, Jingyun Yang, Alex Zijdenbos, Marcel P Zwiers, Ingrid Agartz, Laura Almasy, David Ames, Philippe Amouyel, Ole A Andreassen, Sampath Arepalli, Amelia A Assareh, Sandra Barral, Mark E Bastin, Diane M Becker, James T Becker, David A Bennett, John Blangero, Hans van Bokhoven, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Wiepke Cahn, Vince D Calhoun, Dara M Cannon, Gianpiero L Cavalleri, Ching-Yu Cheng, Sven Cichon, Mark R Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E Curran, Michael Czisch, Anders M Dale, Gareth E Davies, Anton J M De Craen, Eco J C De Geus, Philip L De Jager, Greig I De Zubicaray, Ian J Deary, Stéphanie Debette, Charles DeCarli, Norman Delanty, Chantal Depondt, Anita DeStefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C Drevets, Ravi Duggirala, Thomas D Dyer, Christian Enzinger, Susanne Erk, Thomas Espeseth, Iryna O Fedko, Guillén Fernández, Luigi Ferrucci, Simon E Fisher, Debra A Fleischman, Ian Ford, Myriam Fornage, Tatiana M Foroud, Peter T Fox, Clyde Francks, Masaki Fukunaga, J Raphael Gibbs, David C Glahn, Randy L Gollub, Harald H H Göring, Robert C Green, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Asta K Håberg, Narelle K Hansell, John Hardy, Catharina A Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Dena G Hernandez, Dirk J Heslenfeld, Beng-Choon Ho, Pieter J Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke-Jan Hottenga, Matthew Huentelman, Hilleke E Hulshoff Pol, Masashi Ikeda, Clifford R Jack, Mark Jenkinson, Robert Johnson, Erik G Jönsson, J Wouter Jukema, René S Kahn, Ryota Kanai, Iwona Kloszewska, David S Knopman, Peter Kochunov, John B Kwok, Stephen M Lawrie, Hervé Lemaître, Xinmin Liu, Dan L Longo, Oscar L Lopez, Simon Lovestone, Oliver Martinez, Jean-Luc Martinot, Venkata S Mattay, Colm McDonald, Andrew M McIntosh, Francis J McMahon, Katie L McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Sebastian Mohnke, Grant W Montgomery, Derek W Morris, Thomas H Mosley, Thomas W Mühleisen, Bertram Müller-Myhsok, Michael A Nalls, Matthias Nauck, Thomas E Nichols, Wiro J Niessen, Markus M Nöthen, Lars Nyberg, Kazutaka Ohi, Rene L Olvera, Roel A Ophoff, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W J H Penninx, G Bruce Pike, Steven G Potkin, Bruce M Psaty, Simone Reppermund, Marcella Rietschel, Joshua L Roffman, Nina Romanczuk-Seiferth, Jerome I Rotter, Mina Ryten, Ralph L Sacco, Perminder S Sachdev, Andrew J Saykin, Reinhold E Schmidt, Helena Schmidt, Peter R Schofield, Sigurdur Sigursson, Andrew Simmons, Andrew Singleton, Sanjay M Sisodiya, Colin Smith, Jordan W Smoller, Hilkka Soininen, Vidar M Steen, David J Stott, Jessika E Sussmann, Anbupalam Thalamuthu, Arthur W Toga, Bryan J Traynor, Juan Troncoso, Magda Tsolaki, Christophe Tzourio, Andre G Uitterlinden, Maria C Valdés Hernández, Marcel Van der Brug, Aad van der Lugt, Nic J A van der Wee, Neeltje E M Van Haren, Dennis van 't Ent, Marie-Jose Van Tol, Badri N Vardarajan, Bruno Vellas, Dick J Veltman, Henry Völzke, Henrik Walter, Joanna M Wardlaw, Thomas H Wassink, Michael E Weale, Daniel R Weinberger, Michael W Weiner, Wei Wen, Eric Westman, Tonya White, Tien Y Wong, Clinton B Wright, Ronald H Zielke, Alan B Zonderman, Nicholas G Martin, Cornelia M van Duijn, Margaret J Wright, Jr. W.T. Longstreth, Gunter Schumann, Hans J Grabe, Barbara Franke, Lenore J Launer, Sarah E Medland, Sudha Seshadri, Paul M Thompson, M Arfan Ikram

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

LanguageEnglish
Pages13624
JournalNature Communications
Volume8
DOIs
Publication statusPublished - 18 Jan 2017

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Genetic Loci
loci
Hippocampus
Genes
Episodic Memory
Genome-Wide Association Study
Dentate Gyrus
Medical Genetics
genes
Cognition
Alzheimer Disease
cognition
genome
Brain
abnormalities
Navigation
navigation
upstream
brain
Data storage equipment

Keywords

  • Journal Article

Cite this

Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., ... Ikram, M. A. (2017). Novel genetic loci associated with hippocampal volume. Nature Communications, 8, 13624. https://doi.org/10.1038/ncomms13624
Hibar, Derrek P ; Adams, Hieab H H ; Jahanshad, Neda ; Chauhan, Ganesh ; Stein, Jason L ; Hofer, Edith ; Renteria, Miguel E ; Bis, Joshua C ; Arias-Vasquez, Alejandro ; Ikram, M Kamran ; Desrivières, Sylvane ; Vernooij, Meike W ; Abramovic, Lucija ; Alhusaini, Saud ; Amin, Najaf ; Andersson, Micael ; Arfanakis, Konstantinos ; Aribisala, Benjamin S ; Armstrong, Nicola J ; Athanasiu, Lavinia ; Axelsson, Tomas ; Beecham, Ashley H ; Beiser, Alexa ; Bernard, Manon ; Blanton, Susan H ; Bohlken, Marc M ; Boks, Marco P ; Bralten, Janita ; Brickman, Adam M ; Carmichael, Owen ; Chakravarty, M Mallar ; Chen, Qiang ; Ching, Christopher R K ; Chouraki, Vincent ; Cuellar-Partida, Gabriel ; Crivello, Fabrice ; Den Braber, Anouk ; Doan, Nhat Trung ; Ehrlich, Stefan ; Giddaluru, Sudheer ; Goldman, Aaron L ; Gottesman, Rebecca F ; Grimm, Oliver ; Griswold, Michael E ; Guadalupe, Tulio ; Gutman, Boris A ; Hass, Johanna ; Haukvik, Unn K ; Hoehn, David ; Holmes, Avram J ; Hoogman, Martine ; Janowitz, Deborah ; Jia, Tianye ; Jørgensen, Kjetil N ; Karbalai, Nazanin ; Kasperaviciute, Dalia ; Kim, Sungeun ; Klein, Marieke ; Kraemer, Bernd ; Lee, Phil H ; Liewald, David C M ; Lopez, Lorna M ; Luciano, Michelle ; Macare, Christine ; Marquand, Andre F ; Matarin, Mar ; Mather, Karen A ; Mattheisen, Manuel ; McKay, David R ; Milaneschi, Yuri ; Muñoz Maniega, Susana ; Nho, Kwangsik ; Nugent, Allison C ; Nyquist, Paul ; Loohuis, Loes M Olde ; Oosterlaan, Jaap ; Papmeyer, Martina ; Pirpamer, Lukas ; Pütz, Benno ; Ramasamy, Adaikalavan ; Richards, Jennifer S ; Risacher, Shannon L ; Roiz-Santiañez, Roberto ; Rommelse, Nanda ; Ropele, Stefan ; Rose, Emma J ; Royle, Natalie A ; Rundek, Tatjana ; Sämann, Philipp G ; Saremi, Arvin ; Satizabal, Claudia L ; Schmaal, Lianne ; Schork, Andrew J ; Shen, Li ; Shin, Jean ; Shumskaya, Elena ; Smith, Albert V ; Sprooten, Emma ; Strike, Lachlan T ; Teumer, Alexander ; Tordesillas-Gutierrez, Diana ; Toro, Roberto ; Trabzuni, Daniah ; Trompet, Stella ; Vaidya, Dhananjay ; Van Der Grond, Jeroen ; Van der Lee, Sven J ; Van der Meer, Dennis ; Van Donkelaar, Marjolein M J ; Van Eijk, Kristel R ; Van Erp, Theo G M ; Van Rooij, Daan ; Walton, Esther ; Westlye, Lars T ; Whelan, Christopher D ; Windham, Beverly G ; Winkler, Anderson M ; Wittfeld, Katharina ; Woldehawariat, Girma ; Wolf, Christiane ; Wolfers, Thomas ; Yanek, Lisa R ; Yang, Jingyun ; Zijdenbos, Alex ; Zwiers, Marcel P ; Agartz, Ingrid ; Almasy, Laura ; Ames, David ; Amouyel, Philippe ; Andreassen, Ole A ; Arepalli, Sampath ; Assareh, Amelia A ; Barral, Sandra ; Bastin, Mark E ; Becker, Diane M ; Becker, James T ; Bennett, David A ; Blangero, John ; van Bokhoven, Hans ; Boomsma, Dorret I ; Brodaty, Henry ; Brouwer, Rachel M ; Brunner, Han G ; Buckner, Randy L ; Buitelaar, Jan K ; Bulayeva, Kazima B ; Cahn, Wiepke ; Calhoun, Vince D ; Cannon, Dara M ; Cavalleri, Gianpiero L ; Cheng, Ching-Yu ; Cichon, Sven ; Cookson, Mark R ; Corvin, Aiden ; Crespo-Facorro, Benedicto ; Curran, Joanne E ; Czisch, Michael ; Dale, Anders M ; Davies, Gareth E ; De Craen, Anton J M ; De Geus, Eco J C ; De Jager, Philip L ; De Zubicaray, Greig I ; Deary, Ian J ; Debette, Stéphanie ; DeCarli, Charles ; Delanty, Norman ; Depondt, Chantal ; DeStefano, Anita ; Dillman, Allissa ; Djurovic, Srdjan ; Donohoe, Gary ; Drevets, Wayne C ; Duggirala, Ravi ; Dyer, Thomas D ; Enzinger, Christian ; Erk, Susanne ; Espeseth, Thomas ; Fedko, Iryna O ; Fernández, Guillén ; Ferrucci, Luigi ; Fisher, Simon E ; Fleischman, Debra A ; Ford, Ian ; Fornage, Myriam ; Foroud, Tatiana M ; Fox, Peter T ; Francks, Clyde ; Fukunaga, Masaki ; Gibbs, J Raphael ; Glahn, David C ; Gollub, Randy L ; Göring, Harald H H ; Green, Robert C ; Gruber, Oliver ; Gudnason, Vilmundur ; Guelfi, Sebastian ; Håberg, Asta K ; Hansell, Narelle K ; Hardy, John ; Hartman, Catharina A ; Hashimoto, Ryota ; Hegenscheid, Katrin ; Heinz, Andreas ; Le Hellard, Stephanie ; Hernandez, Dena G ; Heslenfeld, Dirk J ; Ho, Beng-Choon ; Hoekstra, Pieter J ; Hoffmann, Wolfgang ; Hofman, Albert ; Holsboer, Florian ; Homuth, Georg ; Hosten, Norbert ; Hottenga, Jouke-Jan ; Huentelman, Matthew ; Pol, Hilleke E Hulshoff ; Ikeda, Masashi ; Jack, Clifford R ; Jenkinson, Mark ; Johnson, Robert ; Jönsson, Erik G ; Jukema, J Wouter ; Kahn, René S ; Kanai, Ryota ; Kloszewska, Iwona ; Knopman, David S ; Kochunov, Peter ; Kwok, John B ; Lawrie, Stephen M ; Lemaître, Hervé ; Liu, Xinmin ; Longo, Dan L ; Lopez, Oscar L ; Lovestone, Simon ; Martinez, Oliver ; Martinot, Jean-Luc ; Mattay, Venkata S ; McDonald, Colm ; McIntosh, Andrew M ; McMahon, Francis J ; McMahon, Katie L ; Mecocci, Patrizia ; Melle, Ingrid ; Meyer-Lindenberg, Andreas ; Mohnke, Sebastian ; Montgomery, Grant W ; Morris, Derek W ; Mosley, Thomas H ; Mühleisen, Thomas W ; Müller-Myhsok, Bertram ; Nalls, Michael A ; Nauck, Matthias ; Nichols, Thomas E ; Niessen, Wiro J ; Nöthen, Markus M ; Nyberg, Lars ; Ohi, Kazutaka ; Olvera, Rene L ; Ophoff, Roel A ; Pandolfo, Massimo ; Paus, Tomas ; Pausova, Zdenka ; Penninx, Brenda W J H ; Pike, G Bruce ; Potkin, Steven G ; Psaty, Bruce M ; Reppermund, Simone ; Rietschel, Marcella ; Roffman, Joshua L ; Romanczuk-Seiferth, Nina ; Rotter, Jerome I ; Ryten, Mina ; Sacco, Ralph L ; Sachdev, Perminder S ; Saykin, Andrew J ; Schmidt, Reinhold E ; Schmidt, Helena ; Schofield, Peter R ; Sigursson, Sigurdur ; Simmons, Andrew ; Singleton, Andrew ; Sisodiya, Sanjay M ; Smith, Colin ; Smoller, Jordan W ; Soininen, Hilkka ; Steen, Vidar M ; Stott, David J ; Sussmann, Jessika E ; Thalamuthu, Anbupalam ; Toga, Arthur W ; Traynor, Bryan J ; Troncoso, Juan ; Tsolaki, Magda ; Tzourio, Christophe ; Uitterlinden, Andre G ; Hernández, Maria C Valdés ; Van der Brug, Marcel ; van der Lugt, Aad ; van der Wee, Nic J A ; Van Haren, Neeltje E M ; van 't Ent, Dennis ; Van Tol, Marie-Jose ; Vardarajan, Badri N ; Vellas, Bruno ; Veltman, Dick J ; Völzke, Henry ; Walter, Henrik ; Wardlaw, Joanna M ; Wassink, Thomas H ; Weale, Michael E ; Weinberger, Daniel R ; Weiner, Michael W ; Wen, Wei ; Westman, Eric ; White, Tonya ; Wong, Tien Y ; Wright, Clinton B ; Zielke, Ronald H ; Zonderman, Alan B ; Martin, Nicholas G ; van Duijn, Cornelia M ; Wright, Margaret J ; Longstreth, Jr. W.T. ; Schumann, Gunter ; Grabe, Hans J ; Franke, Barbara ; Launer, Lenore J ; Medland, Sarah E ; Seshadri, Sudha ; Thompson, Paul M ; Ikram, M Arfan. / Novel genetic loci associated with hippocampal volume. In: Nature Communications. 2017 ; Vol. 8. pp. 13624.
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abstract = "The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.",
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{Debra A} and Ian Ford and Myriam Fornage and Foroud, {Tatiana M} and Fox, {Peter T} and Clyde Francks and Masaki Fukunaga and Gibbs, {J Raphael} and Glahn, {David C} and Gollub, {Randy L} and G{\"o}ring, {Harald H H} and Green, {Robert C} and Oliver Gruber and Vilmundur Gudnason and Sebastian Guelfi and H{\aa}berg, {Asta K} and Hansell, {Narelle K} and John Hardy and Hartman, {Catharina A} and Ryota Hashimoto and Katrin Hegenscheid and Andreas Heinz and {Le Hellard}, Stephanie and Hernandez, {Dena G} and Heslenfeld, {Dirk J} and Beng-Choon Ho and Hoekstra, {Pieter J} and Wolfgang Hoffmann and Albert Hofman and Florian Holsboer and Georg Homuth and Norbert Hosten and Jouke-Jan Hottenga and Matthew Huentelman and Pol, {Hilleke E Hulshoff} and Masashi Ikeda and Jack, {Clifford R} and Mark Jenkinson and Robert Johnson and J{\"o}nsson, {Erik G} and Jukema, {J Wouter} and Kahn, {Ren{\'e} S} and Ryota Kanai and Iwona Kloszewska and Knopman, {David S} and Peter Kochunov and Kwok, {John B} and 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Sachdev, {Perminder S} and Saykin, {Andrew J} and Schmidt, {Reinhold E} and Helena Schmidt and Schofield, {Peter R} and Sigurdur Sigursson and Andrew Simmons and Andrew Singleton and Sisodiya, {Sanjay M} and Colin Smith and Smoller, {Jordan W} and Hilkka Soininen and Steen, {Vidar M} and Stott, {David J} and Sussmann, {Jessika E} and Anbupalam Thalamuthu and Toga, {Arthur W} and Traynor, {Bryan J} and Juan Troncoso and Magda Tsolaki and Christophe Tzourio and Uitterlinden, {Andre G} and Hern{\'a}ndez, {Maria C Vald{\'e}s} and {Van der Brug}, Marcel and {van der Lugt}, Aad and {van der Wee}, {Nic J A} and {Van Haren}, {Neeltje E M} and {van 't Ent}, Dennis and {Van Tol}, Marie-Jose and Vardarajan, {Badri N} and Bruno Vellas and Veltman, {Dick J} and Henry V{\"o}lzke and Henrik Walter and Wardlaw, {Joanna M} and Wassink, {Thomas H} and Weale, {Michael E} and Weinberger, {Daniel R} and Weiner, {Michael W} and Wei Wen and Eric Westman and Tonya White and Wong, {Tien Y} and Wright, {Clinton B} and Zielke, {Ronald H} and Zonderman, {Alan B} and Martin, {Nicholas G} and {van Duijn}, {Cornelia M} and Wright, {Margaret J} and Longstreth, {Jr. W.T.} and Gunter Schumann and Grabe, {Hans J} and Barbara Franke and Launer, {Lenore J} and Medland, {Sarah E} and Sudha Seshadri and Thompson, {Paul M} and Ikram, {M Arfan}",
year = "2017",
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doi = "10.1038/ncomms13624",
language = "English",
volume = "8",
pages = "13624",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

Hibar, DP, Adams, HHH, Jahanshad, N, Chauhan, G, Stein, JL, Hofer, E, Renteria, ME, Bis, JC, Arias-Vasquez, A, Ikram, MK, Desrivières, S, Vernooij, MW, Abramovic, L, Alhusaini, S, Amin, N, Andersson, M, Arfanakis, K, Aribisala, BS, Armstrong, NJ, Athanasiu, L, Axelsson, T, Beecham, AH, Beiser, A, Bernard, M, Blanton, SH, Bohlken, MM, Boks, MP, Bralten, J, Brickman, AM, Carmichael, O, Chakravarty, MM, Chen, Q, Ching, CRK, Chouraki, V, Cuellar-Partida, G, Crivello, F, Den Braber, A, Doan, NT, Ehrlich, S, Giddaluru, S, Goldman, AL, Gottesman, RF, Grimm, O, Griswold, ME, Guadalupe, T, Gutman, BA, Hass, J, Haukvik, UK, Hoehn, D, Holmes, AJ, Hoogman, M, Janowitz, D, Jia, T, Jørgensen, KN, Karbalai, N, Kasperaviciute, D, Kim, S, Klein, M, Kraemer, B, Lee, PH, Liewald, DCM, Lopez, LM, Luciano, M, Macare, C, Marquand, AF, Matarin, M, Mather, KA, Mattheisen, M, McKay, DR, Milaneschi, Y, Muñoz Maniega, S, Nho, K, Nugent, AC, Nyquist, P, Loohuis, LMO, Oosterlaan, J, Papmeyer, M, Pirpamer, L, Pütz, B, Ramasamy, A, Richards, JS, Risacher, SL, Roiz-Santiañez, R, Rommelse, N, Ropele, S, Rose, EJ, Royle, NA, Rundek, T, Sämann, PG, Saremi, A, Satizabal, CL, Schmaal, L, Schork, AJ, Shen, L, Shin, J, Shumskaya, E, Smith, AV, Sprooten, E, Strike, LT, Teumer, A, Tordesillas-Gutierrez, D, Toro, R, Trabzuni, D, Trompet, S, Vaidya, D, Van Der Grond, J, Van der Lee, SJ, Van der Meer, D, Van Donkelaar, MMJ, Van Eijk, KR, Van Erp, TGM, Van Rooij, D, Walton, E, Westlye, LT, Whelan, CD, Windham, BG, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Wolfers, T, Yanek, LR, Yang, J, Zijdenbos, A, Zwiers, MP, Agartz, I, Almasy, L, Ames, D, Amouyel, P, Andreassen, OA, Arepalli, S, Assareh, AA, Barral, S, Bastin, ME, Becker, DM, Becker, JT, Bennett, DA, Blangero, J, van Bokhoven, H, Boomsma, DI, Brodaty, H, Brouwer, RM, Brunner, HG, Buckner, RL, Buitelaar, JK, Bulayeva, KB, Cahn, W, Calhoun, VD, Cannon, DM, Cavalleri, GL, Cheng, C-Y, Cichon, S, Cookson, MR, Corvin, A, Crespo-Facorro, B, Curran, JE, Czisch, M, Dale, AM, Davies, GE, De Craen, AJM, De Geus, EJC, De Jager, PL, De Zubicaray, GI, Deary, IJ, Debette, S, DeCarli, C, Delanty, N, Depondt, C, DeStefano, A, Dillman, A, Djurovic, S, Donohoe, G, Drevets, WC, Duggirala, R, Dyer, TD, Enzinger, C, Erk, S, Espeseth, T, Fedko, IO, Fernández, G, Ferrucci, L, Fisher, SE, Fleischman, DA, Ford, I, Fornage, M, Foroud, TM, Fox, PT, Francks, C, Fukunaga, M, Gibbs, JR, Glahn, DC, Gollub, RL, Göring, HHH, Green, RC, Gruber, O, Gudnason, V, Guelfi, S, Håberg, AK, Hansell, NK, Hardy, J, Hartman, CA, Hashimoto, R, Hegenscheid, K, Heinz, A, Le Hellard, S, Hernandez, DG, Heslenfeld, DJ, Ho, B-C, Hoekstra, PJ, Hoffmann, W, Hofman, A, Holsboer, F, Homuth, G, Hosten, N, Hottenga, J-J, Huentelman, M, Pol, HEH, Ikeda, M, Jack, CR, Jenkinson, M, Johnson, R, Jönsson, EG, Jukema, JW, Kahn, RS, Kanai, R, Kloszewska, I, Knopman, DS, Kochunov, P, Kwok, JB, Lawrie, SM, Lemaître, H, Liu, X, Longo, DL, Lopez, OL, Lovestone, S, Martinez, O, Martinot, J-L, Mattay, VS, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Mecocci, P, Melle, I, Meyer-Lindenberg, A, Mohnke, S, Montgomery, GW, Morris, DW, Mosley, TH, Mühleisen, TW, Müller-Myhsok, B, Nalls, MA, Nauck, M, Nichols, TE, Niessen, WJ, Nöthen, MM, Nyberg, L, Ohi, K, Olvera, RL, Ophoff, RA, Pandolfo, M, Paus, T, Pausova, Z, Penninx, BWJH, Pike, GB, Potkin, SG, Psaty, BM, Reppermund, S, Rietschel, M, Roffman, JL, Romanczuk-Seiferth, N, Rotter, JI, Ryten, M, Sacco, RL, Sachdev, PS, Saykin, AJ, Schmidt, RE, Schmidt, H, Schofield, PR, Sigursson, S, Simmons, A, Singleton, A, Sisodiya, SM, Smith, C, Smoller, JW, Soininen, H, Steen, VM, Stott, DJ, Sussmann, JE, Thalamuthu, A, Toga, AW, Traynor, BJ, Troncoso, J, Tsolaki, M, Tzourio, C, Uitterlinden, AG, Hernández, MCV, Van der Brug, M, van der Lugt, A, van der Wee, NJA, Van Haren, NEM, van 't Ent, D, Van Tol, M-J, Vardarajan, BN, Vellas, B, Veltman, DJ, Völzke, H, Walter, H, Wardlaw, JM, Wassink, TH, Weale, ME, Weinberger, DR, Weiner, MW, Wen, W, Westman, E, White, T, Wong, TY, Wright, CB, Zielke, RH, Zonderman, AB, Martin, NG, van Duijn, CM, Wright, MJ, Longstreth, JWT, Schumann, G, Grabe, HJ, Franke, B, Launer, LJ, Medland, SE, Seshadri, S, Thompson, PM & Ikram, MA 2017, 'Novel genetic loci associated with hippocampal volume', Nature Communications, vol. 8, pp. 13624. https://doi.org/10.1038/ncomms13624

Novel genetic loci associated with hippocampal volume. / Hibar, Derrek P; Adams, Hieab H H; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L; Hofer, Edith; Renteria, Miguel E; Bis, Joshua C; Arias-Vasquez, Alejandro; Ikram, M Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; Armstrong, Nicola J; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H; Beiser, Alexa; Bernard, Manon; Blanton, Susan H; Bohlken, Marc M; Boks, Marco P; Bralten, Janita; Brickman, Adam M; Carmichael, Owen; Chakravarty, M Mallar; Chen, Qiang; Ching, Christopher R K; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F; Grimm, Oliver; Griswold, Michael E; Guadalupe, Tulio; Gutman, Boris A; Hass, Johanna; Haukvik, Unn K; Hoehn, David; Holmes, Avram J; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil N; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H; Liewald, David C M; Lopez, Lorna M; Luciano, Michelle; Macare, Christine; Marquand, Andre F; Matarin, Mar; Mather, Karen A; Mattheisen, Manuel; McKay, David R; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C; Nyquist, Paul; Loohuis, Loes M Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J; Royle, Natalie A; Rundek, Tatjana; Sämann, Philipp G; Saremi, Arvin; Satizabal, Claudia L; Schmaal, Lianne; Schork, Andrew J; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V; Sprooten, Emma; Strike, Lachlan T; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van Der Grond, Jeroen; Van der Lee, Sven J; Van der Meer, Dennis; Van Donkelaar, Marjolein M J; Van Eijk, Kristel R; Van Erp, Theo G M; Van Rooij, Daan; Walton, Esther; Westlye, Lars T; Whelan, Christopher D; Windham, Beverly G; Winkler, Anderson M; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A; Arepalli, Sampath; Assareh, Amelia A; Barral, Sandra; Bastin, Mark E; Becker, Diane M; Becker, James T; Bennett, David A; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I; Brodaty, Henry; Brouwer, Rachel M; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Bulayeva, Kazima B; Cahn, Wiepke; Calhoun, Vince D; Cannon, Dara M; Cavalleri, Gianpiero L; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E; Czisch, Michael; Dale, Anders M; Davies, Gareth E; De Craen, Anton J M; De Geus, Eco J C; De Jager, Philip L; De Zubicaray, Greig I; Deary, Ian J; Debette, Stéphanie; DeCarli, Charles; Delanty, Norman; Depondt, Chantal; DeStefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C; Duggirala, Ravi; Dyer, Thomas D; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O; Fernández, Guillén; Ferrucci, Luigi; Fisher, Simon E; Fleischman, Debra A; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M; Fox, Peter T; Francks, Clyde; Fukunaga, Masaki; Gibbs, J Raphael; Glahn, David C; Gollub, Randy L; Göring, Harald H H; Green, Robert C; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta K; Hansell, Narelle K; Hardy, John; Hartman, Catharina A; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G; Heslenfeld, Dirk J; Ho, Beng-Choon; Hoekstra, Pieter J; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E Hulshoff; Ikeda, Masashi; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik G; Jukema, J Wouter; Kahn, René S; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L; Lopez, Oscar L; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S; McDonald, Colm; McIntosh, Andrew M; McMahon, Francis J; McMahon, Katie L; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W; Morris, Derek W; Mosley, Thomas H; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Nalls, Michael A; Nauck, Matthias; Nichols, Thomas E; Niessen, Wiro J; Nöthen, Markus M; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L; Ophoff, Roel A; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W J H; Pike, G Bruce; Potkin, Steven G; Psaty, Bruce M; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L; Romanczuk-Seiferth, Nina; Rotter, Jerome I; Ryten, Mina; Sacco, Ralph L; Sachdev, Perminder S; Saykin, Andrew J; Schmidt, Reinhold E; Schmidt, Helena; Schofield, Peter R; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M; Smith, Colin; Smoller, Jordan W; Soininen, Hilkka; Steen, Vidar M; Stott, David J; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, Andre G; Hernández, Maria C Valdés; Van der Brug, Marcel; van der Lugt, Aad; van der Wee, Nic J A; Van Haren, Neeltje E M; van 't Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N; Vellas, Bruno; Veltman, Dick J; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M; Wassink, Thomas H; Weale, Michael E; Weinberger, Daniel R; Weiner, Michael W; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y; Wright, Clinton B; Zielke, Ronald H; Zonderman, Alan B; Martin, Nicholas G; van Duijn, Cornelia M; Wright, Margaret J; Longstreth, Jr. W.T.; Schumann, Gunter; Grabe, Hans J; Franke, Barbara; Launer, Lenore J; Medland, Sarah E; Seshadri, Sudha; Thompson, Paul M; Ikram, M Arfan.

In: Nature Communications, Vol. 8, 18.01.2017, p. 13624.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Novel genetic loci associated with hippocampal volume

AU - Hibar, Derrek P

AU - Adams, Hieab H H

AU - Jahanshad, Neda

AU - Chauhan, Ganesh

AU - Stein, Jason L

AU - Hofer, Edith

AU - Renteria, Miguel E

AU - Bis, Joshua C

AU - Arias-Vasquez, Alejandro

AU - Ikram, M Kamran

AU - Desrivières, Sylvane

AU - Vernooij, Meike W

AU - Abramovic, Lucija

AU - Alhusaini, Saud

AU - Amin, Najaf

AU - Andersson, Micael

AU - Arfanakis, Konstantinos

AU - Aribisala, Benjamin S

AU - Armstrong, Nicola J

AU - Athanasiu, Lavinia

AU - Axelsson, Tomas

AU - Beecham, Ashley H

AU - Beiser, Alexa

AU - Bernard, Manon

AU - Blanton, Susan H

AU - Bohlken, Marc M

AU - Boks, Marco P

AU - Bralten, Janita

AU - Brickman, Adam M

AU - Carmichael, Owen

AU - Chakravarty, M Mallar

AU - Chen, Qiang

AU - Ching, Christopher R K

AU - Chouraki, Vincent

AU - Cuellar-Partida, Gabriel

AU - Crivello, Fabrice

AU - Den Braber, Anouk

AU - Doan, Nhat Trung

AU - Ehrlich, Stefan

AU - Giddaluru, Sudheer

AU - Goldman, Aaron L

AU - Gottesman, Rebecca F

AU - Grimm, Oliver

AU - Griswold, Michael E

AU - Guadalupe, Tulio

AU - Gutman, Boris A

AU - Hass, Johanna

AU - Haukvik, Unn K

AU - Hoehn, David

AU - Holmes, Avram J

AU - Hoogman, Martine

AU - Janowitz, Deborah

AU - Jia, Tianye

AU - Jørgensen, Kjetil N

AU - Karbalai, Nazanin

AU - Kasperaviciute, Dalia

AU - Kim, Sungeun

AU - Klein, Marieke

AU - Kraemer, Bernd

AU - Lee, Phil H

AU - Liewald, David C M

AU - Lopez, Lorna M

AU - Luciano, Michelle

AU - Macare, Christine

AU - Marquand, Andre F

AU - Matarin, Mar

AU - Mather, Karen A

AU - Mattheisen, Manuel

AU - McKay, David R

AU - Milaneschi, Yuri

AU - Muñoz Maniega, Susana

AU - Nho, Kwangsik

AU - Nugent, Allison C

AU - Nyquist, Paul

AU - Loohuis, Loes M Olde

AU - Oosterlaan, Jaap

AU - Papmeyer, Martina

AU - Pirpamer, Lukas

AU - Pütz, Benno

AU - Ramasamy, Adaikalavan

AU - Richards, Jennifer S

AU - Risacher, Shannon L

AU - Roiz-Santiañez, Roberto

AU - Rommelse, Nanda

AU - Ropele, Stefan

AU - Rose, Emma J

AU - Royle, Natalie A

AU - Rundek, Tatjana

AU - Sämann, Philipp G

AU - Saremi, Arvin

AU - Satizabal, Claudia L

AU - Schmaal, Lianne

AU - Schork, Andrew J

AU - Shen, Li

AU - Shin, Jean

AU - Shumskaya, Elena

AU - Smith, Albert V

AU - Sprooten, Emma

AU - Strike, Lachlan T

AU - Teumer, Alexander

AU - Tordesillas-Gutierrez, Diana

AU - Toro, Roberto

AU - Trabzuni, Daniah

AU - Trompet, Stella

AU - Vaidya, Dhananjay

AU - Van Der Grond, Jeroen

AU - Van der Lee, Sven J

AU - Van der Meer, Dennis

AU - Van Donkelaar, Marjolein M J

AU - Van Eijk, Kristel R

AU - Van Erp, Theo G M

AU - Van Rooij, Daan

AU - Walton, Esther

AU - Westlye, Lars T

AU - Whelan, Christopher D

AU - Windham, Beverly G

AU - Winkler, Anderson M

AU - Wittfeld, Katharina

AU - Woldehawariat, Girma

AU - Wolf, Christiane

AU - Wolfers, Thomas

AU - Yanek, Lisa R

AU - Yang, Jingyun

AU - Zijdenbos, Alex

AU - Zwiers, Marcel P

AU - Agartz, Ingrid

AU - Almasy, Laura

AU - Ames, David

AU - Amouyel, Philippe

AU - Andreassen, Ole A

AU - Arepalli, Sampath

AU - Assareh, Amelia A

AU - Barral, Sandra

AU - Bastin, Mark E

AU - Becker, Diane M

AU - Becker, James T

AU - Bennett, David A

AU - Blangero, John

AU - van Bokhoven, Hans

AU - Boomsma, Dorret I

AU - Brodaty, Henry

AU - Brouwer, Rachel M

AU - Brunner, Han G

AU - Buckner, Randy L

AU - Buitelaar, Jan K

AU - Bulayeva, Kazima B

AU - Cahn, Wiepke

AU - Calhoun, Vince D

AU - Cannon, Dara M

AU - Cavalleri, Gianpiero L

AU - Cheng, Ching-Yu

AU - Cichon, Sven

AU - Cookson, Mark R

AU - Corvin, Aiden

AU - Crespo-Facorro, Benedicto

AU - Curran, Joanne E

AU - Czisch, Michael

AU - Dale, Anders M

AU - Davies, Gareth E

AU - De Craen, Anton J M

AU - De Geus, Eco J C

AU - De Jager, Philip L

AU - De Zubicaray, Greig I

AU - Deary, Ian J

AU - Debette, Stéphanie

AU - DeCarli, Charles

AU - Delanty, Norman

AU - Depondt, Chantal

AU - DeStefano, Anita

AU - Dillman, Allissa

AU - Djurovic, Srdjan

AU - Donohoe, Gary

AU - Drevets, Wayne C

AU - Duggirala, Ravi

AU - Dyer, Thomas D

AU - Enzinger, Christian

AU - Erk, Susanne

AU - Espeseth, Thomas

AU - Fedko, Iryna O

AU - Fernández, Guillén

AU - Ferrucci, Luigi

AU - Fisher, Simon E

AU - Fleischman, Debra A

AU - Ford, Ian

AU - Fornage, Myriam

AU - Foroud, Tatiana M

AU - Fox, Peter T

AU - Francks, Clyde

AU - Fukunaga, Masaki

AU - Gibbs, J Raphael

AU - Glahn, David C

AU - Gollub, Randy L

AU - Göring, Harald H H

AU - Green, Robert C

AU - Gruber, Oliver

AU - Gudnason, Vilmundur

AU - Guelfi, Sebastian

AU - Håberg, Asta K

AU - Hansell, Narelle K

AU - Hardy, John

AU - Hartman, Catharina A

AU - Hashimoto, Ryota

AU - Hegenscheid, Katrin

AU - Heinz, Andreas

AU - Le Hellard, Stephanie

AU - Hernandez, Dena G

AU - Heslenfeld, Dirk J

AU - Ho, Beng-Choon

AU - Hoekstra, Pieter J

AU - Hoffmann, Wolfgang

AU - Hofman, Albert

AU - Holsboer, Florian

AU - Homuth, Georg

AU - Hosten, Norbert

AU - Hottenga, Jouke-Jan

AU - Huentelman, Matthew

AU - Pol, Hilleke E Hulshoff

AU - Ikeda, Masashi

AU - Jack, Clifford R

AU - Jenkinson, Mark

AU - Johnson, Robert

AU - Jönsson, Erik G

AU - Jukema, J Wouter

AU - Kahn, René S

AU - Kanai, Ryota

AU - Kloszewska, Iwona

AU - Knopman, David S

AU - Kochunov, Peter

AU - Kwok, John B

AU - Lawrie, Stephen M

AU - Lemaître, Hervé

AU - Liu, Xinmin

AU - Longo, Dan L

AU - Lopez, Oscar L

AU - Lovestone, Simon

AU - Martinez, Oliver

AU - Martinot, Jean-Luc

AU - Mattay, Venkata S

AU - McDonald, Colm

AU - McIntosh, Andrew M

AU - McMahon, Francis J

AU - McMahon, Katie L

AU - Mecocci, Patrizia

AU - Melle, Ingrid

AU - Meyer-Lindenberg, Andreas

AU - Mohnke, Sebastian

AU - Montgomery, Grant W

AU - Morris, Derek W

AU - Mosley, Thomas H

AU - Mühleisen, Thomas W

AU - Müller-Myhsok, Bertram

AU - Nalls, Michael A

AU - Nauck, Matthias

AU - Nichols, Thomas E

AU - Niessen, Wiro J

AU - Nöthen, Markus M

AU - Nyberg, Lars

AU - Ohi, Kazutaka

AU - Olvera, Rene L

AU - Ophoff, Roel A

AU - Pandolfo, Massimo

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Penninx, Brenda W J H

AU - Pike, G Bruce

AU - Potkin, Steven G

AU - Psaty, Bruce M

AU - Reppermund, Simone

AU - Rietschel, Marcella

AU - Roffman, Joshua L

AU - Romanczuk-Seiferth, Nina

AU - Rotter, Jerome I

AU - Ryten, Mina

AU - Sacco, Ralph L

AU - Sachdev, Perminder S

AU - Saykin, Andrew J

AU - Schmidt, Reinhold E

AU - Schmidt, Helena

AU - Schofield, Peter R

AU - Sigursson, Sigurdur

AU - Simmons, Andrew

AU - Singleton, Andrew

AU - Sisodiya, Sanjay M

AU - Smith, Colin

AU - Smoller, Jordan W

AU - Soininen, Hilkka

AU - Steen, Vidar M

AU - Stott, David J

AU - Sussmann, Jessika E

AU - Thalamuthu, Anbupalam

AU - Toga, Arthur W

AU - Traynor, Bryan J

AU - Troncoso, Juan

AU - Tsolaki, Magda

AU - Tzourio, Christophe

AU - Uitterlinden, Andre G

AU - Hernández, Maria C Valdés

AU - Van der Brug, Marcel

AU - van der Lugt, Aad

AU - van der Wee, Nic J A

AU - Van Haren, Neeltje E M

AU - van 't Ent, Dennis

AU - Van Tol, Marie-Jose

AU - Vardarajan, Badri N

AU - Vellas, Bruno

AU - Veltman, Dick J

AU - Völzke, Henry

AU - Walter, Henrik

AU - Wardlaw, Joanna M

AU - Wassink, Thomas H

AU - Weale, Michael E

AU - Weinberger, Daniel R

AU - Weiner, Michael W

AU - Wen, Wei

AU - Westman, Eric

AU - White, Tonya

AU - Wong, Tien Y

AU - Wright, Clinton B

AU - Zielke, Ronald H

AU - Zonderman, Alan B

AU - Martin, Nicholas G

AU - van Duijn, Cornelia M

AU - Wright, Margaret J

AU - Longstreth, Jr. W.T.

AU - Schumann, Gunter

AU - Grabe, Hans J

AU - Franke, Barbara

AU - Launer, Lenore J

AU - Medland, Sarah E

AU - Seshadri, Sudha

AU - Thompson, Paul M

AU - Ikram, M Arfan

PY - 2017/1/18

Y1 - 2017/1/18

N2 - The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

AB - The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

KW - Journal Article

U2 - 10.1038/ncomms13624

DO - 10.1038/ncomms13624

M3 - Article

VL - 8

SP - 13624

JO - Nature Communications

T2 - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E et al. Novel genetic loci associated with hippocampal volume. Nature Communications. 2017 Jan 18;8:13624. https://doi.org/10.1038/ncomms13624