Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

D.J. Gottlieb; K. Hek; T.H. Chen; N.F. Watson; G. Eiriksdottir; E.M. Byrne; M. Cornelis; S.C. Warby; S. Bandinelli; L. Cherkas; D.S. Evans; H.J. Grabe; J. Lahti; M. Li; T. Lehtimäki; T. Lumley; K. Marciante; L. Pérusse; B.M. Psaty; J. Robbins; G. Tranah; J.M. Vink; J.B. Wilk; J.M. Stafford; M. Bellis; R. Biffar; C. Bouchard; B. Cade; G.C. Curhan; J.G. Eriksson; R. Ewert; L. Ferrucci; T. Fülöp; P.R. Gehrman; R. Goodloe; T.B. Harris; A.C. Heath; D. Hernandez; A. Hofman; J.J. Hottenga; D.J. Hunter; M.K. Jensen; A.D. Johnson; M. Kähönen; L. Kao; P. Kraft; E.K. Larkin; D.S. Lauderdale; A.I. Luik; M. Medici; G.W. Montgomery; A. Palotie; S.R. Patel; G. Pistis; E. Porcu; L. Quaye; O. Raitakari; S. Redline; E.B. Rimm; J.I. Rotter; A.V. Smith; T.D. Spector; A. Teumer; A.G. Uitterlinden; M.-C. Vohl; E. Widén; G. Willemsen; T. Young; X. Zhang; Y. Liu; J. Blanger; D.I. Boomsma; V. Gudnason; F. Hu; M. Mangino; N.G. Martin; G.T. O'Connor; K.L. Stone; T. Tanaka; J. Viikari; S.A. Gharib; N.M. Punjabi; K. Räikkönen; H. Völzke; E. Mignot; H. Tiemeier

doi:10.1038/mp.2014.133

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

D.J. Gottlieb, K. Hek, T.H. Chen, N.F. Watson, G. Eiriksdottir, E.M. Byrne, M. Cornelis, S.C. Warby, S. Bandinelli, L. Cherkas, D.S. Evans, H.J. Grabe, J. Lahti, M. Li, T. Lehtimäki, T. Lumley, K. Marciante, L. Pérusse, B.M. Psaty, J. RobbinsG. Tranah, J.M. Vink, J.B. Wilk, J.M. Stafford, M. Bellis, R. Biffar, C. Bouchard, B. Cade, G.C. Curhan, J.G. Eriksson, R. Ewert, L. Ferrucci, T. Fülöp, P.R. Gehrman, R. Goodloe, T.B. Harris, A.C. Heath, D. Hernandez, A. Hofman, J.J. Hottenga, D.J. Hunter, M.K. Jensen, A.D. Johnson, M. Kähönen, L. Kao, P. Kraft, E.K. Larkin, D.S. Lauderdale, A.I. Luik, M. Medici, G.W. Montgomery, A. Palotie, S.R. Patel, G. Pistis, E. Porcu, L. Quaye, O. Raitakari, S. Redline, E.B. Rimm, J.I. Rotter, A.V. Smith, T.D. Spector, A. Teumer, A.G. Uitterlinden, M.-C. Vohl, E. Widén, G. Willemsen, T. Young, X. Zhang, Y. Liu, J. Blanger, D.I. Boomsma, V. Gudnason, F. Hu, M. Mangino, N.G. Martin, G.T. O'Connor, K.L. Stone, T. Tanaka, J. Viikari, S.A. Gharib, N.M. Punjabi, K. Räikkönen, H. Völzke, E. Mignot, H. Tiemeier

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10 -9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10 -4). The strongest combined association was at rs1823125 (P=1.5 × 10 -10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

Original language	English
Pages (from-to)	1232-1239
Number of pages	8
Journal	Molecular Psychiatry
Volume	20
Issue number	10
DOIs	https://doi.org/10.1038/mp.2014.133
Publication status	Published - 2015

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Netherlands Twin Register (NTR)

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10.1038/mp.2014.133

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Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimäki, T., Lumley, T., Marciante, K., Pérusse, L., Psaty, B. M., ... Tiemeier, H. (2015). Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Molecular Psychiatry, 20(10), 1232-1239. https://doi.org/10.1038/mp.2014.133

Gottlieb, D.J. ; Hek, K. ; Chen, T.H. ; Watson, N.F. ; Eiriksdottir, G. ; Byrne, E.M. ; Cornelis, M. ; Warby, S.C. ; Bandinelli, S. ; Cherkas, L. ; Evans, D.S. ; Grabe, H.J. ; Lahti, J. ; Li, M. ; Lehtimäki, T. ; Lumley, T. ; Marciante, K. ; Pérusse, L. ; Psaty, B.M. ; Robbins, J. ; Tranah, G. ; Vink, J.M. ; Wilk, J.B. ; Stafford, J.M. ; Bellis, M. ; Biffar, R. ; Bouchard, C. ; Cade, B. ; Curhan, G.C. ; Eriksson, J.G. ; Ewert, R. ; Ferrucci, L. ; Fülöp, T. ; Gehrman, P.R. ; Goodloe, R. ; Harris, T.B. ; Heath, A.C. ; Hernandez, D. ; Hofman, A. ; Hottenga, J.J. ; Hunter, D.J. ; Jensen, M.K. ; Johnson, A.D. ; Kähönen, M. ; Kao, L. ; Kraft, P. ; Larkin, E.K. ; Lauderdale, D.S. ; Luik, A.I. ; Medici, M. ; Montgomery, G.W. ; Palotie, A. ; Patel, S.R. ; Pistis, G. ; Porcu, E. ; Quaye, L. ; Raitakari, O. ; Redline, S. ; Rimm, E.B. ; Rotter, J.I. ; Smith, A.V. ; Spector, T.D. ; Teumer, A. ; Uitterlinden, A.G. ; Vohl, M.-C. ; Widén, E. ; Willemsen, G. ; Young, T. ; Zhang, X. ; Liu, Y. ; Blanger, J. ; Boomsma, D.I. ; Gudnason, V. ; Hu, F. ; Mangino, M. ; Martin, N.G. ; O'Connor, G.T. ; Stone, K.L. ; Tanaka, T. ; Viikari, J. ; Gharib, S.A. ; Punjabi, N.M. ; Räikkönen, K. ; Völzke, H. ; Mignot, E. ; Tiemeier, H. / Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. In: Molecular Psychiatry. 2015 ; Vol. 20, No. 10. pp. 1232-1239.

@article{abc48e61fd854029929dd13fab49e8dd,

title = "Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study",

abstract = "Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10 -9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10 -4). The strongest combined association was at rs1823125 (P=1.5 × 10 -10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.",

author = "D.J. Gottlieb and K. Hek and T.H. Chen and N.F. Watson and G. Eiriksdottir and E.M. Byrne and M. Cornelis and S.C. Warby and S. Bandinelli and L. Cherkas and D.S. Evans and H.J. Grabe and J. Lahti and M. Li and T. Lehtim{\"a}ki and T. Lumley and K. Marciante and L. P{\'e}russe and B.M. Psaty and J. Robbins and G. Tranah and J.M. Vink and J.B. Wilk and J.M. Stafford and M. Bellis and R. Biffar and C. Bouchard and B. Cade and G.C. Curhan and J.G. Eriksson and R. Ewert and L. Ferrucci and T. F{\"u}l{\"o}p and P.R. Gehrman and R. Goodloe and T.B. Harris and A.C. Heath and D. Hernandez and A. Hofman and J.J. Hottenga and D.J. Hunter and M.K. Jensen and A.D. Johnson and M. K{\"a}h{\"o}nen and L. Kao and P. Kraft and E.K. Larkin and D.S. Lauderdale and A.I. Luik and M. Medici and G.W. Montgomery and A. Palotie and S.R. Patel and G. Pistis and E. Porcu and L. Quaye and O. Raitakari and S. Redline and E.B. Rimm and J.I. Rotter and A.V. Smith and T.D. Spector and A. Teumer and A.G. Uitterlinden and M.-C. Vohl and E. Wid{\'e}n and G. Willemsen and T. Young and X. Zhang and Y. Liu and J. Blanger and D.I. Boomsma and V. Gudnason and F. Hu and M. Mangino and N.G. Martin and G.T. O'Connor and K.L. Stone and T. Tanaka and J. Viikari and S.A. Gharib and N.M. Punjabi and K. R{\"a}ikk{\"o}nen and H. V{\"o}lzke and E. Mignot and H. Tiemeier",

year = "2015",

doi = "10.1038/mp.2014.133",

language = "English",

volume = "20",

pages = "1232--1239",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Nature Publishing Group",

number = "10",

}

Gottlieb, DJ, Hek, K, Chen, TH, Watson, NF, Eiriksdottir, G, Byrne, EM, Cornelis, M, Warby, SC, Bandinelli, S, Cherkas, L, Evans, DS, Grabe, HJ, Lahti, J, Li, M, Lehtimäki, T, Lumley, T, Marciante, K, Pérusse, L, Psaty, BM, Robbins, J, Tranah, G, Vink, JM, Wilk, JB, Stafford, JM, Bellis, M, Biffar, R, Bouchard, C, Cade, B, Curhan, GC, Eriksson, JG, Ewert, R, Ferrucci, L, Fülöp, T, Gehrman, PR, Goodloe, R, Harris, TB, Heath, AC, Hernandez, D, Hofman, A, Hottenga, JJ, Hunter, DJ, Jensen, MK, Johnson, AD, Kähönen, M, Kao, L, Kraft, P, Larkin, EK, Lauderdale, DS, Luik, AI, Medici, M, Montgomery, GW, Palotie, A, Patel, SR, Pistis, G, Porcu, E, Quaye, L, Raitakari, O, Redline, S, Rimm, EB, Rotter, JI, Smith, AV, Spector, TD, Teumer, A, Uitterlinden, AG, Vohl, M-C, Widén, E, Willemsen, G, Young, T, Zhang, X, Liu, Y, Blanger, J, Boomsma, DI, Gudnason, V, Hu, F, Mangino, M, Martin, NG, O'Connor, GT, Stone, KL, Tanaka, T, Viikari, J, Gharib, SA, Punjabi, NM, Räikkönen, K, Völzke, H, Mignot, E & Tiemeier, H 2015, 'Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study', Molecular Psychiatry, vol. 20, no. 10, pp. 1232-1239. https://doi.org/10.1038/mp.2014.133

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. / Gottlieb, D.J.; Hek, K.; Chen, T.H.; Watson, N.F.; Eiriksdottir, G.; Byrne, E.M.; Cornelis, M.; Warby, S.C.; Bandinelli, S.; Cherkas, L.; Evans, D.S.; Grabe, H.J.; Lahti, J.; Li, M.; Lehtimäki, T.; Lumley, T.; Marciante, K.; Pérusse, L.; Psaty, B.M.; Robbins, J.; Tranah, G.; Vink, J.M.; Wilk, J.B.; Stafford, J.M.; Bellis, M.; Biffar, R.; Bouchard, C.; Cade, B.; Curhan, G.C.; Eriksson, J.G.; Ewert, R.; Ferrucci, L.; Fülöp, T.; Gehrman, P.R.; Goodloe, R.; Harris, T.B.; Heath, A.C.; Hernandez, D.; Hofman, A.; Hottenga, J.J.; Hunter, D.J.; Jensen, M.K.; Johnson, A.D.; Kähönen, M.; Kao, L.; Kraft, P.; Larkin, E.K.; Lauderdale, D.S.; Luik, A.I.; Medici, M.; Montgomery, G.W.; Palotie, A.; Patel, S.R.; Pistis, G.; Porcu, E.; Quaye, L.; Raitakari, O.; Redline, S.; Rimm, E.B.; Rotter, J.I.; Smith, A.V.; Spector, T.D.; Teumer, A.; Uitterlinden, A.G.; Vohl, M.-C.; Widén, E.; Willemsen, G.; Young, T.; Zhang, X.; Liu, Y.; Blanger, J.; Boomsma, D.I.; Gudnason, V.; Hu, F.; Mangino, M.; Martin, N.G.; O'Connor, G.T.; Stone, K.L.; Tanaka, T.; Viikari, J.; Gharib, S.A.; Punjabi, N.M.; Räikkönen, K.; Völzke, H.; Mignot, E.; Tiemeier, H.

In: Molecular Psychiatry, Vol. 20, No. 10, 2015, p. 1232-1239.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

AU - Gottlieb, D.J.

AU - Hek, K.

AU - Chen, T.H.

AU - Watson, N.F.

AU - Eiriksdottir, G.

AU - Byrne, E.M.

AU - Cornelis, M.

AU - Warby, S.C.

AU - Bandinelli, S.

AU - Cherkas, L.

AU - Evans, D.S.

AU - Grabe, H.J.

AU - Lahti, J.

AU - Li, M.

AU - Lehtimäki, T.

AU - Lumley, T.

AU - Marciante, K.

AU - Pérusse, L.

AU - Psaty, B.M.

AU - Robbins, J.

AU - Tranah, G.

AU - Vink, J.M.

AU - Wilk, J.B.

AU - Stafford, J.M.

AU - Bellis, M.

AU - Biffar, R.

AU - Bouchard, C.

AU - Cade, B.

AU - Curhan, G.C.

AU - Eriksson, J.G.

AU - Ewert, R.

AU - Ferrucci, L.

AU - Fülöp, T.

AU - Gehrman, P.R.

AU - Goodloe, R.

AU - Harris, T.B.

AU - Heath, A.C.

AU - Hernandez, D.

AU - Hofman, A.

AU - Hottenga, J.J.

AU - Hunter, D.J.

AU - Jensen, M.K.

AU - Johnson, A.D.

AU - Kähönen, M.

AU - Kao, L.

AU - Kraft, P.

AU - Larkin, E.K.

AU - Lauderdale, D.S.

AU - Luik, A.I.

AU - Medici, M.

AU - Montgomery, G.W.

AU - Palotie, A.

AU - Patel, S.R.

AU - Pistis, G.

AU - Porcu, E.

AU - Quaye, L.

AU - Raitakari, O.

AU - Redline, S.

AU - Rimm, E.B.

AU - Rotter, J.I.

AU - Smith, A.V.

AU - Spector, T.D.

AU - Teumer, A.

AU - Uitterlinden, A.G.

AU - Vohl, M.-C.

AU - Widén, E.

AU - Willemsen, G.

AU - Young, T.

AU - Zhang, X.

AU - Liu, Y.

AU - Blanger, J.

AU - Boomsma, D.I.

AU - Gudnason, V.

AU - Hu, F.

AU - Mangino, M.

AU - Martin, N.G.

AU - O'Connor, G.T.

AU - Stone, K.L.

AU - Tanaka, T.

AU - Viikari, J.

AU - Gharib, S.A.

AU - Punjabi, N.M.

AU - Räikkönen, K.

AU - Völzke, H.

AU - Mignot, E.

AU - Tiemeier, H.

PY - 2015

Y1 - 2015

N2 - Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10 -9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10 -4). The strongest combined association was at rs1823125 (P=1.5 × 10 -10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

AB - Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10 -9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10 -4). The strongest combined association was at rs1823125 (P=1.5 × 10 -10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

U2 - 10.1038/mp.2014.133

DO - 10.1038/mp.2014.133

M3 - Article

VL - 20

SP - 1232

EP - 1239

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 10

ER -

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

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