Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Z. Dastani, M.F. Hivert, N.J. Timpson, J.R. Perry, X. Yuan, R.A. Scott, P. Henneman, I.M. Heid, J.R. Kizer, L.P. Lyytikäinen, C. Fuchsberger, T. Tanaka, A.P. Morris, K. Small, A. Isaacs, M. Beekman, S. Coassin, K. Lohman, L. Qi, S. KanoniJ.S. Pankow, H.W. Uh, Y. Wu, A. Bidulescu, L.J. Rasmussen-Torvik, C.M. Greenwood, M. Ladouceur, J. Grimsby, A.K. Manning, C.T. Liu, J. Kooner, V.E. Mooser, P. Vollenweider, K.A. Kapur, J. Chambers, N.J. Wareham, C. Langenberg, R. Frants, K. Willems van Dijk, B.A. Oostra, S.M. Willems, C. Lamina, T.W. Winkler, B.M. Psaty, R.P. Tracy, J. Brody, I. Chen, J. Viikari, M. Kähönen, P.P. Pramstaller, D.M. Evans, B. St Pourcain, N. Sattar, A.R. Wood, S. Bandinelli, O.D. Carlson, J.M. Egan, S. Böhringer, D. van Heemst, L. Kedenko, K. Kristiansson, M.L. Nuotio, B.M. Loo, T. Harris, M. Garcia, A. Kanaya, M. Haun, N. Klopp, H.E. Wichmann, P. Deloukas, E. Katsareli, D.J. Couper, B.B. Duncan, M. Kloppenburg, L.S. Adair, J.B. Borja, J.J. Hottenga, E.J.C. de Geus, G. Willemsen, D.I. Boomsma, J.G. Wilson, G. Musani, X. Guo, T. Johnson, R. Semple, T.M. Teslovich, M.A. Allison, S. Redline, S.G. Buxbaum, K.L. Mohlke, I. Meulenbelt, C.M. Ballantyne, G.V. Dedoussis, F.B. Hu, Y. Liu, B. Paulweber, T.D. Spector, P.E. Slagboom, L. Ferrucci, A. Jula, M. Perola, O. Raitakari, J.C. Florez, V. Salomaa, J.G. Eriksson, T.M. Frayling, A.A. Hicks, T. Lehtimäki, G.D. Smith, D.S. Siscovick, F. Kronenberg, C.M. van Duijn, R.J. Loos, D. Waterworth, J.B. Meigs, J. Dupuis, J.B. Richards, D. Posthuma, B.W.J.H. Penninx, N. Vogelzangs, S. Kathiresan

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Abstract

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10
Original languageEnglish
Article numbere1002607
Pages (from-to)e1002607
JournalPLoS Genetics
Volume8
Issue number3
DOIs
Publication statusPublished - 2012

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