Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Z. Dastani; M.F. Hivert; N.J. Timpson; J.R. Perry; X. Yuan; R.A. Scott; P. Henneman; I.M. Heid; J.R. Kizer; L.P. Lyytikäinen; C. Fuchsberger; T. Tanaka; A.P. Morris; K. Small; A. Isaacs; M. Beekman; S. Coassin; K. Lohman; L. Qi; S. Kanoni; J.S. Pankow; H.W. Uh; Y. Wu; A. Bidulescu; L.J. Rasmussen-Torvik; C.M. Greenwood; M. Ladouceur; J. Grimsby; A.K. Manning; C.T. Liu; J. Kooner; V.E. Mooser; P. Vollenweider; K.A. Kapur; J. Chambers; N.J. Wareham; C. Langenberg; R. Frants; K. Willems van Dijk; B.A. Oostra; S.M. Willems; C. Lamina; T.W. Winkler; B.M. Psaty; R.P. Tracy; J. Brody; I. Chen; J. Viikari; M. Kähönen; P.P. Pramstaller; D.M. Evans; B. St Pourcain; N. Sattar; A.R. Wood; S. Bandinelli; O.D. Carlson; J.M. Egan; S. Böhringer; D. van Heemst; L. Kedenko; K. Kristiansson; M.L. Nuotio; B.M. Loo; T. Harris; M. Garcia; A. Kanaya; M. Haun; N. Klopp; H.E. Wichmann; P. Deloukas; E. Katsareli; D.J. Couper; B.B. Duncan; M. Kloppenburg; L.S. Adair; J.B. Borja; J.J. Hottenga; E.J.C. de Geus; G. Willemsen; D.I. Boomsma; J.G. Wilson; G. Musani; X. Guo; T. Johnson; R. Semple; T.M. Teslovich; M.A. Allison; S. Redline; S.G. Buxbaum; K.L. Mohlke; I. Meulenbelt; C.M. Ballantyne; G.V. Dedoussis; F.B. Hu; Y. Liu; B. Paulweber; T.D. Spector; P.E. Slagboom; L. Ferrucci; A. Jula; M. Perola; O. Raitakari; J.C. Florez; V. Salomaa; J.G. Eriksson; T.M. Frayling; A.A. Hicks; T. Lehtimäki; G.D. Smith; D.S. Siscovick; F. Kronenberg; C.M. van Duijn; R.J. Loos; D. Waterworth; J.B. Meigs; J. Dupuis; J.B. Richards; D. Posthuma; B.W.J.H. Penninx; N. Vogelzangs; S. Kathiresan

doi:10.1371/journal.pgen.1002607

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Z. Dastani, M.F. Hivert, N.J. Timpson, J.R. Perry, X. Yuan, R.A. Scott, P. Henneman, I.M. Heid, J.R. Kizer, L.P. Lyytikäinen, C. Fuchsberger, T. Tanaka, A.P. Morris, K. Small, A. Isaacs, M. Beekman, S. Coassin, K. Lohman, L. Qi, S. KanoniJ.S. Pankow, H.W. Uh, Y. Wu, A. Bidulescu, L.J. Rasmussen-Torvik, C.M. Greenwood, M. Ladouceur, J. Grimsby, A.K. Manning, C.T. Liu, J. Kooner, V.E. Mooser, P. Vollenweider, K.A. Kapur, J. Chambers, N.J. Wareham, C. Langenberg, R. Frants, K. Willems van Dijk, B.A. Oostra, S.M. Willems, C. Lamina, T.W. Winkler, B.M. Psaty, R.P. Tracy, J. Brody, I. Chen, J. Viikari, M. Kähönen, P.P. Pramstaller, D.M. Evans, B. St Pourcain, N. Sattar, A.R. Wood, S. Bandinelli, O.D. Carlson, J.M. Egan, S. Böhringer, D. van Heemst, L. Kedenko, K. Kristiansson, M.L. Nuotio, B.M. Loo, T. Harris, M. Garcia, A. Kanaya, M. Haun, N. Klopp, H.E. Wichmann, P. Deloukas, E. Katsareli, D.J. Couper, B.B. Duncan, M. Kloppenburg, L.S. Adair, J.B. Borja, J.J. Hottenga, E.J.C. de Geus, G. Willemsen, D.I. Boomsma, J.G. Wilson, G. Musani, X. Guo, T. Johnson, R. Semple, T.M. Teslovich, M.A. Allison, S. Redline, S.G. Buxbaum, K.L. Mohlke, I. Meulenbelt, C.M. Ballantyne, G.V. Dedoussis, F.B. Hu, Y. Liu, B. Paulweber, T.D. Spector, P.E. Slagboom, L. Ferrucci, A. Jula, M. Perola, O. Raitakari, J.C. Florez, V. Salomaa, J.G. Eriksson, T.M. Frayling, A.A. Hicks, T. Lehtimäki, G.D. Smith, D.S. Siscovick, F. Kronenberg, C.M. van Duijn, R.J. Loos, D. Waterworth, J.B. Meigs, J. Dupuis, J.B. Richards, D. Posthuma, B.W.J.H. Penninx, N. Vogelzangs, S. Kathiresan

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Abstract

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10

Original language	English
Article number	e1002607
Pages (from-to)	e1002607
Journal	PLoS Genetics
Volume	8
Issue number	3
DOIs	https://doi.org/10.1371/journal.pgen.1002607
Publication status	Published - 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Dastani, Z., Hivert, M. F., Timpson, N. J., Perry, J. R., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L. P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., ... Kathiresan, S. (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3), e1002607. Article e1002607. https://doi.org/10.1371/journal.pgen.1002607

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abstract = "Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10",

author = "Z. Dastani and M.F. Hivert and N.J. Timpson and J.R. Perry and X. Yuan and R.A. Scott and P. Henneman and I.M. Heid and J.R. Kizer and L.P. Lyytik{\"a}inen and C. Fuchsberger and T. Tanaka and A.P. Morris and K. Small and A. Isaacs and M. Beekman and S. Coassin and K. Lohman and L. Qi and S. Kanoni and J.S. Pankow and H.W. Uh and Y. Wu and A. Bidulescu and L.J. Rasmussen-Torvik and C.M. Greenwood and M. Ladouceur and J. Grimsby and A.K. Manning and C.T. Liu and J. Kooner and V.E. Mooser and P. Vollenweider and K.A. Kapur and J. Chambers and N.J. Wareham and C. Langenberg and R. Frants and {Willems van Dijk}, K. and B.A. Oostra and S.M. Willems and C. Lamina and T.W. Winkler and B.M. Psaty and R.P. Tracy and J. Brody and I. Chen and J. Viikari and M. K{\"a}h{\"o}nen and P.P. Pramstaller and D.M. Evans and {St Pourcain}, B. and N. Sattar and A.R. Wood and S. Bandinelli and O.D. Carlson and J.M. Egan and S. B{\"o}hringer and {van Heemst}, D. and L. Kedenko and K. Kristiansson and M.L. Nuotio and B.M. Loo and T. Harris and M. Garcia and A. Kanaya and M. Haun and N. Klopp and H.E. Wichmann and P. Deloukas and E. Katsareli and D.J. Couper and B.B. Duncan and M. Kloppenburg and L.S. Adair and J.B. Borja and J.J. Hottenga and {de Geus}, E.J.C. and G. Willemsen and D.I. Boomsma and J.G. Wilson and G. Musani and X. Guo and T. Johnson and R. Semple and T.M. Teslovich and M.A. Allison and S. Redline and S.G. Buxbaum and K.L. Mohlke and I. Meulenbelt and C.M. Ballantyne and G.V. Dedoussis and F.B. Hu and Y. Liu and B. Paulweber and T.D. Spector and P.E. Slagboom and L. Ferrucci and A. Jula and M. Perola and O. Raitakari and J.C. Florez and V. Salomaa and J.G. Eriksson and T.M. Frayling and A.A. Hicks and T. Lehtim{\"a}ki and G.D. Smith and D.S. Siscovick and F. Kronenberg and {van Duijn}, C.M. and R.J. Loos and D. Waterworth and J.B. Meigs and J. Dupuis and J.B. Richards and D. Posthuma and B.W.J.H. Penninx and N. Vogelzangs and S. Kathiresan",

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pages = "e1002607",

journal = "PLoS Genetics",

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Dastani, Z, Hivert, MF, Timpson, NJ, Perry, JR, Yuan, X, Scott, RA, Henneman, P, Heid, IM, Kizer, JR, Lyytikäinen, LP, Fuchsberger, C, Tanaka, T, Morris, AP, Small, K, Isaacs, A, Beekman, M, Coassin, S, Lohman, K, Qi, L, Kanoni, S, Pankow, JS, Uh, HW, Wu, Y, Bidulescu, A, Rasmussen-Torvik, LJ, Greenwood, CM, Ladouceur, M, Grimsby, J, Manning, AK, Liu, CT, Kooner, J, Mooser, VE, Vollenweider, P, Kapur, KA, Chambers, J, Wareham, NJ, Langenberg, C, Frants, R, Willems van Dijk, K, Oostra, BA, Willems, SM, Lamina, C, Winkler, TW, Psaty, BM, Tracy, RP, Brody, J, Chen, I, Viikari, J, Kähönen, M, Pramstaller, PP, Evans, DM, St Pourcain, B, Sattar, N, Wood, AR, Bandinelli, S, Carlson, OD, Egan, JM, Böhringer, S, van Heemst, D, Kedenko, L, Kristiansson, K, Nuotio, ML, Loo, BM, Harris, T, Garcia, M, Kanaya, A, Haun, M, Klopp, N, Wichmann, HE, Deloukas, P, Katsareli, E, Couper, DJ, Duncan, BB, Kloppenburg, M, Adair, LS, Borja, JB, Hottenga, JJ , de Geus, EJC, Willemsen, G, Boomsma, DI, Wilson, JG, Musani, G, Guo, X, Johnson, T, Semple, R, Teslovich, TM, Allison, MA, Redline, S, Buxbaum, SG, Mohlke, KL, Meulenbelt, I, Ballantyne, CM, Dedoussis, GV, Hu, FB, Liu, Y, Paulweber, B, Spector, TD, Slagboom, PE, Ferrucci, L, Jula, A, Perola, M, Raitakari, O, Florez, JC, Salomaa, V, Eriksson, JG, Frayling, TM, Hicks, AA, Lehtimäki, T, Smith, GD, Siscovick, DS, Kronenberg, F, van Duijn, CM, Loos, RJ, Waterworth, D, Meigs, JB, Dupuis, J, Richards, JB, Posthuma, D, Penninx, BWJH, Vogelzangs, N & Kathiresan, S 2012, 'Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals', PLoS Genetics, vol. 8, no. 3, e1002607, pp. e1002607. https://doi.org/10.1371/journal.pgen.1002607

TY - JOUR

T1 - Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

AU - Dastani, Z.

AU - Hivert, M.F.

AU - Timpson, N.J.

AU - Perry, J.R.

AU - Yuan, X.

AU - Scott, R.A.

AU - Henneman, P.

AU - Heid, I.M.

AU - Kizer, J.R.

AU - Lyytikäinen, L.P.

AU - Fuchsberger, C.

AU - Tanaka, T.

AU - Morris, A.P.

AU - Small, K.

AU - Isaacs, A.

AU - Beekman, M.

AU - Coassin, S.

AU - Lohman, K.

AU - Qi, L.

AU - Kanoni, S.

AU - Pankow, J.S.

AU - Uh, H.W.

AU - Wu, Y.

AU - Bidulescu, A.

AU - Rasmussen-Torvik, L.J.

AU - Greenwood, C.M.

AU - Ladouceur, M.

AU - Grimsby, J.

AU - Manning, A.K.

AU - Liu, C.T.

AU - Kooner, J.

AU - Mooser, V.E.

AU - Vollenweider, P.

AU - Kapur, K.A.

AU - Chambers, J.

AU - Wareham, N.J.

AU - Langenberg, C.

AU - Frants, R.

AU - Willems van Dijk, K.

AU - Oostra, B.A.

AU - Willems, S.M.

AU - Lamina, C.

AU - Winkler, T.W.

AU - Psaty, B.M.

AU - Tracy, R.P.

AU - Brody, J.

AU - Chen, I.

AU - Viikari, J.

AU - Kähönen, M.

AU - Pramstaller, P.P.

AU - Evans, D.M.

AU - St Pourcain, B.

AU - Sattar, N.

AU - Wood, A.R.

AU - Bandinelli, S.

AU - Carlson, O.D.

AU - Egan, J.M.

AU - Böhringer, S.

AU - van Heemst, D.

AU - Kedenko, L.

AU - Kristiansson, K.

AU - Nuotio, M.L.

AU - Loo, B.M.

AU - Harris, T.

AU - Garcia, M.

AU - Kanaya, A.

AU - Haun, M.

AU - Klopp, N.

AU - Wichmann, H.E.

AU - Deloukas, P.

AU - Katsareli, E.

AU - Couper, D.J.

AU - Duncan, B.B.

AU - Kloppenburg, M.

AU - Adair, L.S.

AU - Borja, J.B.

AU - Hottenga, J.J.

AU - de Geus, E.J.C.

AU - Willemsen, G.

AU - Boomsma, D.I.

AU - Wilson, J.G.

AU - Musani, G.

AU - Guo, X.

AU - Johnson, T.

AU - Semple, R.

AU - Teslovich, T.M.

AU - Allison, M.A.

AU - Redline, S.

AU - Buxbaum, S.G.

AU - Mohlke, K.L.

AU - Meulenbelt, I.

AU - Ballantyne, C.M.

AU - Dedoussis, G.V.

AU - Hu, F.B.

AU - Liu, Y.

AU - Paulweber, B.

AU - Spector, T.D.

AU - Slagboom, P.E.

AU - Ferrucci, L.

AU - Jula, A.

AU - Perola, M.

AU - Raitakari, O.

AU - Florez, J.C.

AU - Salomaa, V.

AU - Eriksson, J.G.

AU - Frayling, T.M.

AU - Hicks, A.A.

AU - Lehtimäki, T.

AU - Smith, G.D.

AU - Siscovick, D.S.

AU - Kronenberg, F.

AU - van Duijn, C.M.

AU - Loos, R.J.

AU - Waterworth, D.

AU - Meigs, J.B.

AU - Dupuis, J.

AU - Richards, J.B.

AU - Posthuma, D.

AU - Penninx, B.W.J.H.

AU - Vogelzangs, N.

AU - Kathiresan, S.

PY - 2012

Y1 - 2012

N2 - Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10

AB - Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10

U2 - 10.1371/journal.pgen.1002607

DO - 10.1371/journal.pgen.1002607

M3 - Article

SN - 1553-7390

VL - 8

SP - e1002607

JO - PLoS Genetics

JF - PLoS Genetics

IS - 3

M1 - e1002607

ER -

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

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UN SDGs

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