Novel nirK cluster genes in Nitrosomonas europaea are required for NirK-dependent tolerance to nitrite

Hubertus J E Beaumont, Sylvia I Lens, Hans V Westerhoff, Rob J M van Spanning

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Nitrite reductase (NirK) of Nitrosomonas europaea confers tolerance to nitrite (NO2-). The nirK gene is clustered with three genes of unknown physiological function: ncgABC. At present, this organization is unique to nitrifying bacteria. Here we report that the ncgABC gene products facilitate NirK-dependent NO2- tolerance by reversing the negative physiological effect that is associated with the activity of NirK in their absence. We hypothesize that the ncg gene products are involved in the detoxification of nitric oxide that is produced by NirK.

Original languageEnglish
Pages (from-to)6849-51
Number of pages3
JournalJournal of Bacteriology
Volume187
Issue number19
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Genes, Bacterial
  • Multigene Family
  • Mutation
  • Nitric Oxide
  • Nitrite Reductases
  • Nitrites
  • Nitrosomonas europaea
  • Operon
  • Oxidoreductases
  • Journal Article
  • Research Support, Non-U.S. Gov't

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