TY - JOUR
T1 - Novel piperidine erivatives: inhibitory properties towards cytochrome P450 isoforms, and cytoprotective and cytotoxic characteristics.
AU - Alexidis, A.N.
AU - Commandeur, J.N.M.
AU - Rekka, E.A.
AU - Groot, E
PY - 1996
Y1 - 1996
N2 - The ability of a series of eight piperidine derivatives, substituted at positions 1, 3 and 4, to inhibit P450-dependent metabolism of specific substrates, is reported. Five different P450 isoforms (1A1, 1A2, 2B1, 2E1 and 3A1) in differentially induced rat liver microsomes were used for this purpose. From the results it is concluded that compound 2 was the most potent and moreover, highly selective inhibitor for P4502B1 with an IC
AB - The ability of a series of eight piperidine derivatives, substituted at positions 1, 3 and 4, to inhibit P450-dependent metabolism of specific substrates, is reported. Five different P450 isoforms (1A1, 1A2, 2B1, 2E1 and 3A1) in differentially induced rat liver microsomes were used for this purpose. From the results it is concluded that compound 2 was the most potent and moreover, highly selective inhibitor for P4502B1 with an IC
U2 - 10.1016/1382-6689(95)00012-7
DO - 10.1016/1382-6689(95)00012-7
M3 - Article
SN - 1382-6689
VL - 1
SP - 81
EP - 88
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
ER -
